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Novel and highly potent neuro-protective molecule P7C3

Oct 13,2014 03:55  |  news

Just published in last month Cell, recent MOA study of the neuro-protective small moleculeP7C3, which has broad in vitro and in vivo activities, offers new exciting opportunities in studying neurological diseases, injuries, development, and degenerative diseases in other tissues sharing common mechanisms.
 
 
P7C3 is a nontoxic, stable, and orally bioavailable synthetic small molecule identified directly from an in vivo neurogenesis screening. It can protect newborn neurons in the dentate gyrus and stimulates the growth of new neurons. It can also enhance learning and memory in aged rats. P7C3 can also preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). MOA study showed P7C3 could bind nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme involved in the conversion of nicotinamide into nicotinamide adenine dinucleotide (NAD). Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity.
 
 
How to order: Xcess Biosciences, a premier reagent and service company, provides compounds in 10 mM DMSO solution and up to grams solid form. Please visit our website for order information, and other innovative products. Especially Xcess Biosciences continues to add more novel small molecule chemical probes to our Epigenetic Modulator Tool Box (right now we offer 72 unique compounds) and Ubiquitin Modulator Tool Box (right now we offer 15 unique compounds). 
 
 
Reference:
  1. Pieper AA, et al. Discovery of a proneurogenic, neuroprotective chemical. (2010) Cell 142(1), 39-51. 
  2. Saxe JP. Screening: Your brain on drugs. (2010) Nat Chem Biol. 6(9):639-40
  3. MacMillan KS, et al. Development of Proneurogenic, Neuroprotective Small Molecules. (2011) Journal of the American Chemical Society, 133(5), 1428-1437.
  4. De Jesús-Cortés H, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. (2012) Proc Natl Acad Sci USA. 109(42):17010-5.
  5. Wang G, et al. P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage. (2014) Cell. 158(6):1324-34.
  6. Yin TC, et al. P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury. (2014) Cell Rep. 8(6):1731-40.