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Items 51 to 60 of 229 total

  1. DZNep (3-Deazaneplanocin A) --- Histone Methyltransferase Inhibitor

    Catalog No. M60141
    An S-adenosylhomocysteine hydrolase inhibitor, indirectly inhibiting histone methyltransferases and decreasing global DNA methylation
  2. EED226, PRC2 Inhibitor

    Catalog No. M60327
    A potent and selective allosteric PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED.
  3. EML425, CBP/p300 Inhibitor

    Catalog No. M60257
    A selective, noncompetitive and cell permeable KAT3 histone acetyltransferases CBP/p300 inhibitor.
  4. Entinostat (MS-275) -- HDAC Inhibitor

    Catalog No. M60174
    Entinostat (MS-275) is a potent and selective HDAC1 and HDAC3 inhibitor.
  5. EPZ-5676 --- DOT1L inhibitor

    Catalog No. M60123
    A highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S-adenosylmethionine.
  6. EPZ-6438, EZH2 Methyltransferase Inhibitor

    Catalog No. M60122
    EPZ-6438 (E7438) is a potent and selective small molecule inhibitor of histone methyltransferase EZH2 in clinical development.
  7. EPZ015666 (GSK3235025), PRMT5 Inhibitor

    Catalog No. M60254
    A potent, selective and orally bioavailable Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  8. FASCIN-G2, Fascin Inhibitor

    Catalog No. M60269
    A potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin.
  9. Ferrostatin-1 (Fer-1), Ferroptosis Inhibitor

    Catalog No. M60042
    Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis with an EC50 ~60 nM, identified by a HTS using erastin-induced ferroptosis in HT-1080 cells.
  10. FG-4592 (Roxadustat), HIF Prolyl-Hydroxylases Inhibitor

    Catalog No. M60263
    A potent, selective and bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylase.
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