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Anti-cancer

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  1. EML425, CBP/p300 Inhibitor

    $129.00
    Catalog No. M60257
    A selective, noncompetitive and cell permeable KAT3 histone acetyltransferases CBP/p300 inhibitor.
  2. Entinostat (MS-275) -- HDAC Inhibitor

    $59.00
    Catalog No. M60174
    Entinostat (MS-275) is a potent and selective HDAC1 and HDAC3 inhibitor.
  3. EPZ-5676 --- DOT1L inhibitor

    $139.00
    Catalog No. M60123
    A highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S-adenosylmethionine.
  4. EPZ-6438, EZH2 Methyltransferase Inhibitor

    $129.00
    Catalog No. M60122
    EPZ-6438 (E7438) is a potent and selective small molecule inhibitor of histone methyltransferase EZH2 in clinical development.
  5. EPZ015666 (GSK3235025), PRMT5 Inhibitor

    $129.00
    Catalog No. M60254
    A potent, selective and orally bioavailable Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  6. FASCIN-G2, Fascin Inhibitor

    $129.00
    Catalog No. M60269
    A potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin.
  7. Ferrostatin-1 (Fer-1), Ferroptosis Inhibitor

    $109.00
    Catalog No. M60042
    Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis with an EC50 ~60 nM, identified by a HTS using erastin-induced ferroptosis in HT-1080 cells.
  8. FG-4592 (Roxadustat), HIF Prolyl-Hydroxylases Inhibitor

    $39.00
    Catalog No. M60263
    A potent, selective and bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylase.
  9. FLI-06, Notch Pathway Modulator

    $139.00
    Catalog No. M60149
    FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 µM), identified by using automated microscopy to monitor the trafficking and processing of a ligand-independent Notch-GFP fusion reporter.
  10. Forskolin, Adenylyl Cyclase Activator

    $79.00
    Catalog No. M60024
    A potent adenylate cyclase activator to increase the intracellular levels of cAMP.
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