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Items 1 to 226 of 226 total

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  1. (+)-JQ1, BET Inhibitor

    $109.00   $139.00
    Catalog No. M60139
    A potent and selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4
  2. (R)-2-HG, a-KG-dependent dioxygenases inhibitor

    $69.00
    Catalog No. M60104
    An a-KG-dependent dioxygenases inhibitor
  3. (S)-crizotinib, MTH1 Inhibitor

    $99.00
    Catalog No. M60208
    A novel potent, selective and cell permeable MTH1 inhibitor.
  4. (Z)-4-Hydroxytamoxifen, CRISPR Editing Enhancer

    $89.00
    Catalog No. M60324
    Previously characterized as an Estrogen Receptor antagonist and now found to improve genome-editing specificity in CRISPR-mediated gene editing
  5. 1-methyl-D-tryptophan (D-1MT), IDO Inhibitor

    $29.00
    Catalog No. M60291
    A potent and selective indoleamine 2,3-dioxygenase (IDO) inhibitor.
  6. 4SC-202, HDAC/LSD1 Dual Inhibitor

    $109.00
    Catalog No. M60230
    A potent, selective and orally bioavailable HDAC/LSD1 dual Inhibitor.
  7. 5-Azacytidine, DNA Methyltransferase Inhibitor

    $59.00
    Catalog No. M60131
    A classic DNA methyltransferase inhibitor, incorporates into DNA forming covalent adducts with cellular DNMT, depleting enzyme activity.
  8. A-366, G9a/GLP HMTase Inhibitor

    $139.00
    Catalog No. M60210
    A novel highly potent, selective and cell permeable G9a/GLP histone lysine methyltransferase inhibitor.
  9. A01, Smurf1 E3 Ubiquitin Ligase Inhibitor

    $109.00
    Catalog No. M60249
    A potent and selective Smurf1 E3 ubiquitin ligase inhibitor.
  10. AA92593, Antagonist of Melanopsin-mediated Photo-transduction

    $139.00
    Catalog No. M60143
    A potent and selective small molecule antagonist of melanopsin-mediated photo-transduction.
  11. Abiraterone, CYP17 inhibitor Abiraterone (CB-7598)

    $69.00
    Catalog No. M60031
    A first-in-class CYP17 inhibitor approved to treat castration-resistant prostate cancer.
  12. ABT-199, BCL-2 inhibitor

    $99.00
    Catalog No. M60075
    A potent BCL-2–selective (BCL-X L) inhibitor with clinical efficacy.
  13. AG-120 (Ivosidenib), IDH1 Inhibitor

    $129.00
    Catalog No. M60318
    A potent, selective and reversible inhibitor of IDH1 in clinical trials.
  14. AG-221 (Enasidenib), IHD2 Inhibitor

    $129.00
    Catalog No. M60296
    A potent and selective inhibitor of IDH2 R140Q mutant.
  15. APY29, IRE1a Modulator

    $109.00
    Catalog No. M60168
    A highly potent and selective small molecule modulator of IRE1α.
  16. AZD6244 (Selumetinib), MEK Inhibitor

    $109.00
    Catalog No. M60067
    A potent and highly selective non-ATP competitive MEK inhibitor in clinical trials.
  17. Azidothymidine (AZT), Reverse Transcriptase Inhibitor

    $29.00
    Catalog No. M60238
    A selective, orally bioavailable and brain penetrant reverse transcriptase inhibitor.
  18. b-AP15 (NSC687852), Deubiquitinases Inhibitor

    $89.00
    Catalog No. M60251
    A potent and selective deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage.
  19. BAM7, BAX Activator

    $109.00
    Catalog No. M60069
    The first potent and selective small molecule activator of BAX, which is a pro-apoptotic BCL-2 family member.
  20. BAY 87-2243, Hypoxia-inducible Factor-1 (HIF-1) Inhibitor

    $119.00
    Catalog No. M60217
    A highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.
  21. BAY11-7082, E2 Ubiquitin Conjugating Enzyme Inhibitor

    $89.00
    Catalog No. M60309
    A potent and selective E2 ubiquitin (Ub) conjugating enzyme inhibitor.
  22. BG45, HDAC3 Inhibitor

    $59.00
    Catalog No. M60266
    A potent, selective and cell permeable HDAC3 inhibitor.
  23. BI-2536, PLK1 and BRD4 Dual Inhibitor

    $119.00
    Catalog No. M60171
    BI-2536 is a potent inhibitor of PLK1 (Polo-like kinase 1) and BRD4 in clinical trials.
  24. BI-7273, BRD9 Bromodomain Inhibitor

    $129.00
    Catalog No. M60322
    A potent, selective and cell-permeable BRD9 inhibitor.
  25. BI-9564, BRD9 Bromodomain Inhibitor

    $129.00
    Catalog No. M60323
    A potent, selective and cell-permeable BRD9 inhibitor.
  26. BIBW2992(Afatinib), EGFR Inhibitor

    $109.00
    Catalog No. M60065-5s
    A potent and selective irreversible inhibitor of EGFR/HER2 in clinical trials.
  27. Bioymifi, TRAIL Receptor DR5 Activator

    $109.00
    Catalog No. M60088
    A potent and selective small molecule agonist of DR5.
  28. BIX-01294, G9a/GLP HMTase Inhibitor

    $79.00
    Catalog No. M60216
    A potent and selective G9a and GLP histone lysine methyltransferase inhibitor.
  29. BQU57, GTPase Ral Inhibitor

    $139.00
    Catalog No. M60228
    A potent and selective GTPase Ral Inhibitor
  30. Bromosporine, Pan-bromodomain Inhibitor

    $129.00
    Catalog No. M60144
    A broad spectrum inhibitor for bromodomains.
  31. C646, p300/CBP inhibitor

    $129.00
    Catalog No. M60129
    A potent, selective and cell-permeable p300/CBP histone acetyltransferase (HAT) inhibitor.
  32. CAY10603, HDAC6 Inhibitor

    $129.00
    Catalog No. M60234
    A potent and selective HDAC6 inhibitor.
  33. CB-5083, p97 AAA ATPase Inhibitor

    $129.00
    Catalog No. M60306
    A highly potent, selective and orally bioavailable p97 AAA ATPase inhibitor.
  34. CI994 (Tacedinaline), HDAC Inhibitor

    $59.00
    Catalog No. M60186
    A potent, selective and orally active histone deacetylase (HDAC) inhibitor targeting HDAC1, HDAC2 and HDAC3.
  35. CP-690550, JAK Inhibitor

    $79.00
    Catalog No. M60033
    A potent and selective pan-JAK Inhibitor in clinical trials for rheumatoid arthritis.
  36. CPI-169, EZH2 Methyltransferase Inhibitor

    $129.00
    Catalog No. M60275
    A highly potent and selective small molecule inhibitor of histone methyltransferase EZH2.
  37. CPI-455, KDM5 Demethylases Inhibitor

    $129.00
    Catalog No. M60326
    A potent and selective KDM5A inhibitor.
  38. CPI203, BET Inhibitor

    $139.00
    Catalog No. M60124
    A novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4, inhibiting Myc expression.
  39. CUDC-101, HDAC/EGFR/HER2 Inhibitor

    $69.00
    Catalog No. M60092
    A potent multi-target inhibitor targeting HDAC, EGFR and HER2 in clinical trial.
  40. CX-4945, CK2 (Casein Kinase 2) Inhibitor

    $129.00
    Catalog No. M60267
    A potent, selective and bioavailable CK2 (Casein Kinase 2) Inhibitor.
  41. CX-5461, RNA Polymerase I inhibitor

    $149.00
    Catalog No. M66052
    A potent and selective RNA Polymerase I inhibitor, for anti-tumor use.
  42. Cyclosporin A, MPTP Inhibitor and HSC Protector

    $39.00
    Catalog No. M60262
    An inhibitor of the mitochondrial permeability transition pore (MPTP).
  43. Daminozide --- KDM2/7 Histone Demethylases Inhibitor

    $69.00
    Catalog No. M60074
    A potent and selective small molecule inhibitor of the KDM2/7 family of human JmjC histone demethylases.
  44. DAPT, γ-secretase Inhibitor

    $300.00
    Catalog No. M60023
    A γ-secretase inhibitor and widely used as a Notch pathway inhibitor.
  45. DASA-58 (ML203), Pyruvate Kinase M2 (PKM2) Activator

    $109.00
    Catalog No. M60305
    A potent and selective Pyruvate kinase M2 (PKM2) activator.
  46. Deltarasin, KRAS-PDEδ Inhibitor

    $139.00
    Catalog No. M60218
    A potent and selective small molecular inhibitor of KRAS-PDEδ interaction
  47. DMOG, Prolyl 4-hydroxylase (P4H) Inhibitor

    $39.00
    Catalog No. M60287
    A selective, competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor.
  48. DMXAA (Vadimezan), mSTING Agonist

    $79.00
    Catalog No. M60301
    A potent and selective mSTING agonist, selective for mouse STING over human STING.
  49. DZNep (3-Deazaneplanocin A) --- Histone Methyltransferase Inhibitor

    $129.00
    Catalog No. M60141
    An S-adenosylhomocysteine hydrolase inhibitor, indirectly inhibiting histone methyltransferases and decreasing global DNA methylation
  50. EED226, PRC2 Inhibitor

    $139.00
    Catalog No. M60327
    A potent and selective allosteric PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED.
  51. EML425, CBP/p300 Inhibitor

    $129.00
    Catalog No. M60257
    A selective, noncompetitive and cell permeable KAT3 histone acetyltransferases CBP/p300 inhibitor.
  52. Entinostat (MS-275) -- HDAC Inhibitor

    $59.00
    Catalog No. M60174
    Entinostat (MS-275) is a potent and selective HDAC1 and HDAC3 inhibitor.
  53. EPZ-5676 --- DOT1L inhibitor

    $139.00
    Catalog No. M60123
    A highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S-adenosylmethionine.
  54. EPZ-6438, EZH2 Methyltransferase Inhibitor

    $129.00
    Catalog No. M60122
    EPZ-6438 (E7438) is a potent and selective small molecule inhibitor of histone methyltransferase EZH2 in clinical development.
  55. EPZ015666 (GSK3235025), PRMT5 Inhibitor

    $129.00
    Catalog No. M60254
    A potent, selective and orally bioavailable Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  56. FASCIN-G2, Fascin Inhibitor

    $129.00
    Catalog No. M60269
    A potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin.
  57. Ferrostatin-1 (Fer-1), Ferroptosis Inhibitor

    $109.00
    Catalog No. M60042
    Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis with an EC50 ~60 nM, identified by a HTS using erastin-induced ferroptosis in HT-1080 cells.
  58. FG-4592 (Roxadustat), HIF Prolyl-Hydroxylases Inhibitor

    $39.00
    Catalog No. M60263
    A potent, selective and bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylase.
  59. FLI-06, Notch Pathway Modulator

    $139.00
    Catalog No. M60149
    FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 µM), identified by using automated microscopy to monitor the trafficking and processing of a ligand-independent Notch-GFP fusion reporter.
  60. Forskolin, Adenylyl Cyclase Activator

    $79.00
    Catalog No. M60024
    A potent adenylate cyclase activator to increase the intracellular levels of cAMP.
  61. Furamidine, PRMT1 Inhibitor

    $99.00
    Catalog No. M60256
    A potent, selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor.
  62. GDC-0068, Akt Inhibitor

    $159.00
    Catalog No. M60066
    A novel potent and selective ATP competitive Akt inhibitor in clinical trials.
  63. GDC-0349, mTOR Inhibitor

    $129.00
    Catalog No. M60110
    A potent and selective ATP-competitive inhibitor of mTOR in clinical trials.
  64. GDC-0449 (Vismodegib), Hedgehog Antagonist

    $79.00
    Catalog No. M60034
    A potent and specific hedgehog pathway inhibitor approved by FDA
  65. GDC-0941, PI3K Inhibitor

    $79.00
    Catalog No. M60111
    A highly potent, selective and orally bioavailable class-I PI3K kinase inhibitor.
  66. GN44028, HIF-1α Inhibitor

    $89.00
    Catalog No. M60325
    A potent and selective HIF-1α inhibitor.
  67. GNF-7, Ras Signaling Inhibitor

    $129.00
    Catalog No. M60281
    A potent, selective and bioavailable Ras signaling inhibitor.
  68. Go6893, PKC Inhibitor

    $129.00
    Catalog No. M60273
    A potent pan-PKC inhibitor.
  69. GS143, IkappaB Ubiquitination Inhibitor

    $129.00
    Catalog No. M60308
    A selective β-TrCP1 ligase inhibitor
  70. GSK-J1, H3K27 Histone Demethylases UTX and JMJD3 Inhibitor

    $109.00
    Catalog No. M60062
    The first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3.
  71. GSK-J4, H3K27 Histone Demethylases UTX and JMJD3 Inhibitor

    $109.00
    Catalog No. M60063
    An ethyl ester derivative of GSK-J1 as a pro-drug for cellular assays; the first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3.
  72. GSK-LSD1, LSD1 Inhibitor

    $139.00
    Catalog No. M60179
    A highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1).
  73. GSK126, EZH2 Methyltransferase Inhibitor.

    $129.00
    Catalog No. M60071
    GSK126 is a highly potent and selective small molecule inhibitor of histone methyltransferase EZH2.
  74. GSK2801, Bromodomain BAZ2A/B Inhibitor

    $129.00
    Catalog No. M60283
    A potent, selective and cell permeable inhibitor of the bromodomain BAZ2A and BAZ2B.
  75. GSK2879552, LSD1 Inhibitor

    $129.00
    Catalog No. M60297
    A highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1).
  76. GSK343, EZH2 Methyltransferase Inhibitor

    $79.00
    Catalog No. M60173
    GSK343 is a potent and selective small molecule inhibitor of histone methyltransferase EZH2.
  77. GSK591 (EPZ015866), PRMT5 Inhibitor

    $109.00
    Catalog No. M60321
    A potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  78. GSK5959, BRPF1 Bromodomain Inhibitor

    $129.00
    Catalog No. M60239
    A potent, selective and cell permeable BRPF1 bromodomain inhibitor.
  79. HBX41108, USP7 Inhibitor

    $129.00
    Catalog No. M60244
    A potent and selective ubiquitin-specific protease 7 (USP7) inhibitor.
  80. HCI-2509 (SP2509), Reversible LSD1 Inhibitor.

    $109.00
    Catalog No. M60160
    A highly potent, specific, and reversible Lysine Specific Demethylase-1 (LSD1) inhibitor with in vivo efficacy.
  81. Heclin, HECT E3 Ubiquitin Ligase Inhibitor

    $89.00
    Catalog No. M60248
    A selective HECT E3 ubiquitin ligase inhibitor to inhibit Nedd4, Smurf2 and WWP1.
  82. HIF-C2, HIF-2 Inhibitor

    $139.00
    Catalog No. M60121
    A potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2).
  83. HLCL-61, PRMT5 Inhibitor

    $109.00
    Catalog No. M60320
    A potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  84. HPOB, HDAC6 Inhibitor

    $79.00
    Catalog No. M60231
    A potent and selective HDAC6 inhibitor.
  85. Hydroxychloroquine (HCQ), Autophagy and TLR9 Inhibitor

    $49.00
    Catalog No. M60302
    A potent autophagy inhibitor and TLR9 inhibitor
  86. I-BET151 (GSK1210151A), BET Inhibitor

    $109.00
    Catalog No. M66053
    A potent and selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4.
  87. I-BET762 (GSK525762), BET Inhibitor

    $139.00
    Catalog No. M60154
    A novel, highly potent, selective and cell permeable BET inhibitor in clinical trials.
  88. I-BRD9, Bromodomain Containing Protein 9 (BRD9) Inhibitor

    $129.00
    Catalog No. M60276
    A potent, selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor.
  89. I-CBP112, p300/CBP Bromodomain Inhibitor

    $139.00
    Catalog No. M60128
    A highly potent and selective p300/CBP bromodomain inhibitor.
  90. IDH-C227, IDH1 Inhibitor

    $139.00
    Catalog No. M60043
    A potent and selective inhibitor of the IDH1 R132H mutant with good cellular activity.
  91. IDH2-C100, IHD2 Inhibitor

    $129.00
    Catalog No. M60190
    A potent and selective inhibitor of IDH2 R140Q and R172K mutant.
  92. INCB024360 (Epacadostat), IDO Inhibitor

    $109.00
    Catalog No. M60292
    A potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor.
  93. IOX1, 2OG Oxygenases Inhibitor

    $109.00
    Catalog No. M60195
    A cell-permeable broad-spectrum inhibitor of most 2OG oxygenases.
  94. IOX2, HIF Prolyl-Hydroxylases (PHD2) Inhibitor

    $89.00
    Catalog No. M66054
    A potent and selective PHD (HIF prolyl-hydroxylases) inhibitor with cellular activity.
  95. IOX4, PHD2 Inhibitor

    $109.00
    Catalog No. M60284
    A potent and selective PHD2 inhibitor.
  96. IRE-3, IRE1a Modulator

    $129.00
    Catalog No. M60167
    A highly potent and selective small molecule modulator of IRE1α.
  97. Ischemin, CBP Bromodomain Inhibitor

    $79.00
    Catalog No. M60229
    A potent, selective and cell permeable CBP bromodomain inhibitor.
  98. IU1, Proteasome USP14 Inhibitor

    $49.00
    Catalog No. M60203
    A cell-permeable, reversible and selective inhibitor of human proteasome USP14.
  99. JIB-04 (NSC693627), Jumonji Histone Demethylase Inhibitor

    $119.00
    Catalog No. M60132
    A potent, selective and cell permeable Jumonji histone demethylase inhibitor, not a competitive inhibitor of a-ketoglutarate.
  100. JK184, Hedgehog Antagonist

    $79.00
    Catalog No. M60087
    A potent and cell-permeable inhibitor of hedgehog (Hh) signaling downstream of Smo.
  101. JNJ-42041935, HIF-PHD Inhibitor

    $129.00
    Catalog No. M60285
    A potent and selective HIF-PHD inhibitor.
  102. KDM5-C70, JARID1 Histone Demethylases Inhibitor

    $139.00
    Catalog No. M60192
    An ethyl ester derivative of KDM5-C49, which is a potent and selective inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases.
  103. KRAS-C9, K-Ras(G12C) Inhibitor

    $139.00
    Catalog No. M60219
    A potent and selective allosteric inhibitor of oncogenic K-Ras(G12C).
  104. KYA1797K, Wnt/β-catenin Inhibitor

    $129.00
    Catalog No. M60317
    A highly potent and selective Wnt/β-catenin inhibitor binding directly to the regulators of G-protein signaling domain of axin.
  105. L002 (NSC764414), p300 Inhibitor

    $99.00
    Catalog No. M60198
    A novel selective, cell permeable and reversible inhibitor of p300 histone acetyl transferase.
  106. LDE225, Hedgehog Antagonist

    $99.00
    Catalog No. M60013
    A potent and specific Hedgehog pathway inhibitor (Smo antagonist) in clinical trials.
  107. LDN-57444, Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor

    $69.00
    Catalog No. M60204
    A novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1).
  108. LGK974, Porcupine (Wnt) Inhibitor

    $139.00
    Catalog No. M60106
    A highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) in clinical trials.
  109. LLY-507, Protein-lysine Methyltransferase SMYD2 Inhibitor

    $129.00
    Catalog No. M60259
    A potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor.
  110. LMK235, HDAC4 and HDAC5 Inhibitor

    $89.00
    Catalog No. M60145
    A potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor.
  111. LSD1-C76, LSD1 Inhibitor

    $159.00
    Catalog No. M66045
    The most potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor so far.
  112. LY2109761, TGFβ Inhibitor

    $109.00
    Catalog No. M60035
    A novel potent and selective TGFβ receptor type I and type II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM respectively.
  113. LY2157299, TGFβ Inhibitor

    $169.00
    Catalog No. M60064
    A novel potent and selective TGFβ receptor type I and type II (TβRI/II) inhibitor with IC50 of 86 nM and 2 nM respectively.
  114. LY2784544, JAK2 inhibitor

    $129.00
    Catalog No. M60079
    A highly potent and selective mutant JAK2 (V617F) inhibitor.
  115. LY294002, PI3K/BET Dual Inhibitor

    $79.00
    Catalog No. M60157
    A potent and selective small molecule PI3K and BET bromodomain dual inhibitor.
  116. MALT1-MI-2 (MI-2), MALT1 inhibitor

    $129.00
    Catalog No. M60098
    A highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function.
  117. MC1568, Class IIa HDAC Inhibitor

    $79.00
    Catalog No. M60224
    A potent and selective inhibitor of class IIa histone deacetylases (HDACs), more selective for HD1-A than HD1-B.
  118. MEK162 (ARRY-162), MEK Inhibitor

    $119.00
    Catalog No. M60080
    A highly potent, selective, and orally bioavailable MEK inhibitor in clinical trials.
  119. MHY1485, mTOR Activator

    $49.00
    Catalog No. M60189
    A novel potent, selective and cell-permeable mTOR activator.
  120. MI-2, Menin-MLL Inhibitor

    $119.00
    Catalog No. M66046
    A highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function.
  121. MK-1775 (AZD1775), WEE1 Inhibitor

    $129.00
    Catalog No. M60299
    A highly potent, selective and orally bioavailable Wee1 kinase inhibitor.
  122. ML228, HIF Pathway Activator

    $129.00
    Catalog No. M60130
    A potent and selective hypoxia inducible factor (HIF) pathway activator.
  123. ML239, Breast Cancer Stem Cell Inhibitor

    $129.00
    Catalog No. M60282
    A potent and selective breast cancer stem cell inhibitor.
  124. ML323, USP1-UAF1 Inhibitor

    $139.00
    Catalog No. M60188
    A potent, selective and reversible inhibitor of the USP1-UAF1 deubiquitinase complex.
  125. MLN8237 (Alisertib), Aurora A inhibitor

    $119.00
    Catalog No. M60093
    A highly potent and selective Aurora A inhibitor with >200-fold selective towards Aurora B.
  126. MM-102, WDR5-MLL1 Antagonist

    $129.00
    Catalog No. M60166
    A highly potent and selective inhibitor of the MLL1/WDR5 interaction.
  127. MRT68921, Autophagy Kinase ULK1/2 Inhibitor

    $109.00
    Catalog No. M60311
    A potent, selective and dual autophagy kinase ULK1/2 inhibitor.
  128. MS023, PRMT Inhibitor

    $109.00
    Catalog No. M60314
    A potent, selective and cell permeable type I PRMT inhibitor.
  129. MS436, BRD4 Inhibitor

    $109.00
    Catalog No. M60232
    A potent and selective BET bromodomain inhibitor for BRD4 (1) and BRD4 (2).
  130. MSAB, β-catenin Inhibitor

    $129.00
    Catalog No. M60316
    A potent and selective Wnt/β-catenin inhibitor identified using cell-based chemical screening.
  131. N106, SERCA2a SUMOylation Activator

    $129.00
    Catalog No. M60271
    A potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a.
  132. Napabucasin (BBI608), STAT3 Inhibitor

    $89.00
    Catalog No. M60303
    A potent and selective STAT3 inhibitor.
  133. NI-57, BRPF Bromodomain Inhibitor

    $109.00
    Catalog No. M60279
    A potent and selective inhibitor of the bromodomain of the BRPFs.
  134. NLG919 (RG6078), IDO Inhibitor

    $129.00
    Catalog No. M60258
    A potent, selective and orally bioavailable IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor.
  135. NMS-859, ATPase VCP/p97 Inhibitor

    $139.00
    Catalog No. M60148
    A potent and specific small molecule covalent inhibitor of the ATPase VCP/p97.
  136. NMS-873, ATPase VCP/p97 Inhibitor

    $139.00
    Catalog No. M60165
    A potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97.
  137. NSC319726, Mutant p53 Activator

    $89.00
    Catalog No. M66047
    A potent and selective activator of the most common p53R175 mutant, restoring the mutant p53 to its WT structure and function.
  138. NSC636819, KDM4A/KDM4B Inhibitor

    $109.00
    Catalog No. M60290
    A cell permeable and selective novel active-site KDM4A/KDM4B inhibitor.
  139. NSC697923, Ub-conjugating Enzyme (E2) Inhibitor

    $69.00
    Catalog No. M60202
    A cell permeable, potent and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.
  140. NU9056--- KAT5 (Tip60) Histone Acetyltransferase Inhibitor

    $69.00
    Catalog No. M60147
    A potent and selective KAT5 (Tip60) histone acetyltransferase inhibitor.
  141. NVP-BGT226, PI3K/mTOR Dual Inhibitor

    $89.00
    Catalog No. M66050
    A PI3K/mTOR dual inhibitor in clinical trials for advanced solid tumors.
  142. NVP-BKM120, PI3K Inhibitor BKM120

    $89.00
    Catalog No. M66051
    A selective PI3K Inhibitor in clinical trials for advanced solid tumors.
  143. NVP-TNKS656, Wnt / Tankyrase Inhibitor

    $109.00
    Catalog No. M60328
    A highly potent, selective and oral bioavailable tankyrase inhibitor for TNKS2.
  144. OF-1, BRPF Bromodomain Inhibitor

    $129.00
    Catalog No. M60222
    A potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor.
  145. OG-L002, LSD1 Inhibitor

    $89.00
    Catalog No. M60161
    A highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1).
  146. OICR9429, WDR5 Antagonist

    $129.00
    Catalog No. M60255
    A potent and selective WD repeat-containing protein 5 (WDR5) antagonist.
  147. ORY-1001 (RG-6016), LSD1 Inhibitor

    $129.00
    Catalog No. M60295
    A highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) in phase I/II.
  148. OSI-027, mTOR Inhibitor

    $109.00
    Catalog No. M60113
    OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2
  149. OTX015, BET Inhibitor

    $89.00
    Catalog No. M60193
    OTX015 is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10-19 nM.
  150. P22077, USP7 inhibitor

    $99.00
    Catalog No. M60019
    A potent and selective USP7 inhibitor.
  151. P5091, Ubiquitin-specific Protease 7 (USP7) Inhibitor

    $79.00
    Catalog No. M60205
    P5091 (P005091) is a novel potent and selective inhibitor of ubiquitin-specific protease 7 (USP7)
  152. PBIT, JARID1 Histone Demethylases Inhibitor

    $129.00
    Catalog No. M60170
    PBIT is a potent, specific, reversible and cell-permeable inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases.
  153. PCI-34051, HDAC8 Inhibitor

    $79.00
    Catalog No. M60178
    PCI-34051 is a potent and selective inhibitor of histone deacetylase 8 (HDAC8).
  154. PD-1/PD-L1 Inhibitor C1

    $109.00
    Catalog No. M60312
    A potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions.
  155. PD0325901, MEK Inhibitor

    $69.00
    Catalog No. M60018
    A potent and selective MEK inhibitor.
  156. PF-04979064, PI3K/mTOR Dual Inhibitor

    $149.00
    Catalog No. M60114
    PF-04979064 is a highly potent and orally bioavailable PI3K/mTOR dual inhibitor developed through structure-based drug design.
  157. PF-CBP1,CBP/p300 Bromodomain Inhibitor

    $129.00
    Catalog No. M60313
    A potent and selective CBP/p300 bromodomain inhibitor.
  158. PFI-1, BET Inhibitor

    $129.00
    Catalog No. M60120
    PFI-1 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2 and BRD4.
  159. PFI-2, SETD7 Histone Lysine Methyltransferase Inhibitor

    $139.00
    Catalog No. M60182
    PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor.
  160. PFI-3, SMARCA Bromodomains Inhibitor

    $139.00
    Catalog No. M60175
    PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains.
  161. PFI-4, BRPF1 Bromodomain Inhibitor

    $129.00
    Catalog No. M60264
    A potent, selective and cell permeable BRPF1 bromodomain inhibitor.
  162. PR-619, Deubiquitinylating Enzyme (DUB) Inhibitor

    $59.00
    Catalog No. M60199
    PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs).
  163. PRMT1-2e, Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor

    $69.00
    Catalog No. M60181
    PRMT1-2e is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1).
  164. PRT4165, E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor

    $39.00
    Catalog No. M60245
    A potent and selective E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor.
  165. PTC-209, BMI-1 Inhibitor

    $129.00
    Catalog No. M60159
    PTC-209 is a novel potent and selective BMI-1 inhibitor, targeting the BMI-1 self-renewal machinery.
  166. PX-478, Hypoxia-inducible Factor-1α (HIF-1α) Inhibitor

    $129.00
    Catalog No. M60227
    A highly potent and selective Hypoxia-inducible Factor-1α (HIF-1α) inhibitor.
  167. PYR-41---Ubiquitin-activating Enzyme E1 Inhibitor

    $59.00
    Catalog No. M60201
    PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1
  168. PYZD-4409, Ubiquitin-activating Enzyme (E1) Inhibitor

    $139.00
    Catalog No. M60213
    A novel potent, selective and cell permeable inhibitor of ubiquitin-activating enzyme (E1).
  169. RA190, Ubiquitin Receptor RPN13/ADRM1 Inhibitor

    $139.00
    Catalog No. M60163
    A novel potent and selective inhibitor of proteasome Ubiquitin receptor RPN13/ADRM1.
  170. Rapamycin, mTOR inhibitor

    $89.00
    Catalog No. M60029
    A potent and selective mTOR inhibitor, directly binding to the mTOR Complex 1 (mTORC1).
  171. Remodelin, Acetyl-transferase NAT10 Inhibitor

    $139.00
    Catalog No. M60187
    Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
  172. RG108---DNA Methyltransferase Inhibitor

    $65.00
    Catalog No. M60176
    RG108 is a potent, selective and cell permeable inhibitor of DNA methyltransferase.
  173. RG2833 (RGFP109), Brain-penetrant HDAC Inhibitor

    $69.00
    Catalog No. M60225
    A potent and selective brain-penetrant HDAC inhibitor HDAC1 and HDAC3.
  174. RGFP966, HDAC3 Inhibitor

    $89.00
    Catalog No. M60156
    RGFP966 is a potent and selective HDAC3 inhibitor.
  175. RN-1, LSD1 Inhibitor

    $109.00
    Catalog No. M60169
    RN-1 is a potent, specific and brain-penetrant Lysine Specific Demethylase-1 (LSD1) inhibitor.
  176. RO4929097, γ-Secretase Inhibitor

    $109.00
    Catalog No. M60007
    A potent and selective γ-secretase inhibitor; inhibits Notch signaling in stem cells and tumor cells.
  177. RS-1, CRISPR Editing Enhancer

    $89.00
    Catalog No. M60300
    Previously characterized as a RAD51-Stimulatory compound and now found to be an HDR enhancer to enhance CRISPR/Cas9- and TALEN-mediated knock-in efficiency
  178. RU-SKI 43, Hhat Inhibitor

    $139.00
    Catalog No. M60100
    The first potent and specific small molecule inhibitor of Hedgehog acyltransferase (Hhat).
  179. Ryuvidine, Lysine Methyltransferase SETD8 Inhibitor

    $129.00
    Catalog No. M60252
    A potent, selective and cell permeable lysine methyltransferase SETD8 inhibitor.
  180. SB431542, TGF-beta Inhibitor

    $300.00
    Catalog No. M60015
    A potent and selective TGF-β pathway inhibitor (selective for ALK4, ALK5 and ALK7).
  181. SBI-0206965, Autophagy Kinase ULK1 Inhibitor

    $129.00
    Catalog No. M60268
    A potent, selective and cell permeable autophagy kinase ULK1 inhibitor.
  182. SCH51344, MTH1 Inhibitor

    $139.00
    Catalog No. M60212
    A novel potent, selective and cell permeable MTH1 inhibitor.
  183. SCR7, NHEJ inhibitor

    $129.00
    Catalog No. M60082
    A potent and selective inhibitor of non-homologous end joining (NHEJ).
  184. SD70, Histone Demethylase JMJD2 Inhibitor

    $139.00
    Catalog No. M60194
    A potent, selective and cell-permeable inhibitor of histone demethylase JMJD2 (KDM4C).
  185. Sephin1, PPP1R15A Protein Phosphatase Inhibitor

    $129.00
    Catalog No. M60280
    A potent, selective and bioavailable inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1.
  186. SGC-CBP30, p300/CBP Bromodomain Inhibitor

    $139.00
    Catalog No. M60138
    SGC-CBP30 is a highly potent and selective p300/CBP bromodomain inhibitor
  187. SGC0946, DOT1L inhibitor

    $139.00
    Catalog No. M60101
    A highly potent and selective inhibitor of DOT1L methyltransferase.
  188. SGC707, Allosteric PRMT3 Inhibitor

    $129.00
    Catalog No. M60243
    A potent, selective and cell permeable allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor.
  189. SGI-1027, DNMT Inhibitor

    $89.00
    Catalog No. M60155
    A potent and selective inhibitor of DNA methyltransferase (DNMT).
  190. SHP099, SHP2 Phosphatase Inhibitor

    $139.00
    Catalog No. M60319
    A highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor.
  191. SirReal2, Sirt2 Inhibitor

    $119.00
    Catalog No. M60289
    A potent and selective Sirt2 inhibitor.
  192. SKP2-C25, Skp2 Inhibitor

    $139.00
    Catalog No. M60136
    A potent, selective and cell permeable Skp2 inhibitor, selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes.
  193. SKPin C1, Skp2 Inhibitor

    $109.00
    Catalog No. M60137
    A potent and selective inhibitor of Skp2-mediated p27 degradation.
  194. SMER3, SCF family E3 Ubiquitin Ligase Inhibitor

    $129.00
    Catalog No. M60250
    A potent and selective a yeast SCF family E3 ubiquitin ligase inhibitor, also a small-molecule enhancers of rapamycin.
  195. Spautin-1, Autophagy Inhibitor

    $69.00
    Catalog No. M60003
    A potent autophagy inhibitor, selectively promotes the degradation of Vps34 complexes.
  196. SR9243, LXR Inverse Agonist

    $129.00
    Catalog No. M60270
    A highly potent and selective small molecule LXR inverse agonist that induces LXR-corepressor interaction.
  197. TAME, Ubiquitin Ligase APC/C Inhibitor

    $29.00
    Catalog No. M60246
    A competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C).
  198. Tasquinimod, Allosteric HDAC4 Inhibitor

    $129.00
    Catalog No. M60235
    A potent and selective allosteric HDAC4 inhibitor.
  199. TEPP-46 (ML265), Pyruvate Kinase M2 (PKM2) Activator

    $129.00
    Catalog No. M60304
    A potent and selective Pyruvate kinase M2 (PKM2) activator.
  200. TG101348 (SAR302503), JAK2 and BRD4 Dual Inhibitor

    $109.00
    Catalog No. M60172
    TG101348 is a potent, specific and orally bioavailable inhibitor of JAK2 and BRD4 in clinical trials.
  201. TH-302, Hypoxia-activated Pro-drug

    $179.00
    Catalog No. M60089
    A highly potent and selective hypoxia-activated pro-drug targeting hypoxic regions of solid tumors.
  202. TH588, MTH1 Inhibitor

    $139.00
    Catalog No. M60211
    A novel potent, selective and cell permeable MTH1 inhibitor.
  203. THZ1, Covalent CDK7 Inhibitor

    $159.00
    Catalog No. M60214
    A novel potent, selective and cell permeable irreversible CDK7 inhibitor.
  204. TMP269, Class IIa HDAC Inhibitor

    $129.00
    Catalog No. M60119
    A highly potent, selective and cell-permeable class IIa HDAC inhibitor.
  205. TRIM24-C34, BRPF1B/TRIM24 Dual Inhibitor

    $99.00
    Catalog No. M60265
    A potent, selective and cell permeable BRPF1B and TRIM24 dual inhibitor.
  206. TZ9, Rad6 Ubiquitin Inhibitor

    $109.00
    Catalog No. M60286
    A selective and cell permeable inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B.
  207. UF010, HDAC Inhibitor

    $89.00
    Catalog No. M60278
    UF010 is a potent and selective class I HADC inhibitor.
  208. UNC0379, Lysine Methyltransferase SETD8 Inhibitor

    $129.00
    Catalog No. M60207
    A novel selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8
  209. UNC0638, G9a HMTase Inhibitor

    $89.00
    Catalog No. M66056
    A potent, selective and cell permeable inhibitor of G9a (EHMT2) and GLP (EHMT1) histone methyltransferases.
  210. UNC0642, G9a/GLP HMTase Inhibitor

    $129.00
    Catalog No. M60185
    A novel highly potent, selective and cell permeable inhibitor of the homologous protein lysine methyltransferases, G9a and GLP, with improved PK properties.
  211. UNC0646, G9a/GLP HMTase Inhibitor

    $89.00
    Catalog No. M60184
    A novel potent, selective and cell permeable homologous protein lysine methyltransferases G9a and GLP inhibitor.
  212. UNC1215, L3MBTL3 Domain Inhibitor

    $119.00
    Catalog No. M60084
    A highly potent and selective small molecule inhibitor for the methyl-lysine (Kme) reading function of L3MBTL3.
  213. UNC2170, Methyl-lysine Binding Protein 53BP1 Inhibitor

    $99.00
    Catalog No. M60260
    A selective and cell permeable methyl-lysine binding protein 53BP1 antagonist.
  214. UNC2327, Allosteric PRMT3 Inhibitor

    $129.00
    Catalog No. M60253
    A potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor.
  215. UNC669, L3MBTL1 Domain Inhibitor

    $89.00
    Catalog No. M60083
    A potent and selective small molecule inhibitor for the methyl-lysine (Kme) reading function of L3MBTL1
  216. Verteporfin (Visudyne), YAP Inhibitor

    $59.00
    Catalog No. M60247
    A potent and selective YAP inhibitor to disrupt YAP-TEAD interactions and enhance trypsin cleavage of YAP.
  217. VLX600, Mitochondrial OXPHOS Inhibitor

    $69.00
    Catalog No. M60261
    A potent and selective mitochondrial OXPHOS inhibitor.
  218. VR23, Proteasome Inhibitor

    $99.00
    Catalog No. M60307
    A potent and selective proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 μM for trypsin-like proteasomes, chymotrypsin-like proteasomes,
  219. WAY-316606, Secreted Frizzled-related Protein-1 (sFRP-1) Inhibitor

    $139.00
    Catalog No. M60215
    A novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) to increase Wnt signaling.
  220. WDR5-0103, WDR5 Inhibitor

    $89.00
    Catalog No. M60233
    A potent and selective WD repeat-containing protein 5 (WDR5) antagonist.
  221. WDR5-C47, WDR5-MLL (SET1) Antagonist

    $129.00
    Catalog No. M60118
    A highly potent and selective antagonist of WDR5-MLL interaction.
  222. Wnt-C59, Wnt Antagonist

    $89.00
    Catalog No. M60005
    A potent, selective and oral active Wnt  signaling pathway antagonist.
  223. WP1130 (Degrasyn), Deubiquitinylating Enzyme (DUB) Inhibitor

    $69.00
    Catalog No. M60206
    A cell-permeable, potent and selective inhibitor of the deubiquitinylating enzymes (DUBs).
  224. XAV939---Wnt Antagonist

    $89.00
    Catalog No. M60010
    A potent and selective Wnt pathway antagonist; functions to stabilize axin by inhibiting tankyrase 1 and tankyrase 2.
  225. XL888---HSP90 Inhibitor

    $149.00
    Catalog No. M60164
    A highly potent, ATP-competitive and orally bioavailable Hsp90 inhibitor.
  226. ZCL278---Cdc42 GTPase Inhibitor

    $119.00
    Catalog No. M60133
    A potent and selective inhibitor of Cdc42 GTPase.
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