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AR7, RARα antagonist

AR7, RARα antagonist

$129.00
A highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RARα.
Catalog No. Unit Price Qty
M60116-2s 2 mg solid $129.00
M60116-2 10 mM DMSO (0.776 mL) $129.00

Details

Product Information
CAS#: 80306-38-3
Purity: ≥98%
Formula: C15H12ClNO
Molecular Weight: 257.71
Solubility: DMSO up to 100 mM
Chemical Name: 7-chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

AR7 is a specific and potent RARα antagonist (IC50 < 100 nM) to stimulate Chaperone-mediated autophagy (CMA).It is a synthetic derivative of all-trans-retinoic acid developed through the structure-based chemical design. CMA contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. A decrease in CMA activity occurs in aging and in age-related disorders (for example, neurodegenerative diseases and diabetes). AR7 working as a chemical enhancement of CMA protects cells from oxidative stress and from proteotoxicity, and supports a potential therapeutic opportunity when reduced CMA contributes to cellular dysfunction and disease. AR7 is the first chemical compound that affects CMA has the selectivity for this pathway without affecting macroautophagy.


How to Use:

In vitro:  AR7 was suggested to be used at 5-20 µM final concentration in vitro and in cellular assays.

In vivo:  n/a


Reference:

  1. 1. Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. (2013) Nat Chem Biol. 9(6):374-82.

   AR7_spec.pdf

   AR7_MSDS.pdf 


Products are for research use only. Not for human use. 

Description

Details

Product Information
CAS#: 80306-38-3
Purity: ≥98%
Formula: C15H12ClNO
Molecular Weight: 257.71
Solubility: DMSO up to 100 mM
Chemical Name: 7-chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

AR7 is a specific and potent RARα antagonist (IC50 < 100 nM) to stimulate Chaperone-mediated autophagy (CMA).It is a synthetic derivative of all-trans-retinoic acid developed through the structure-based chemical design. CMA contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. A decrease in CMA activity occurs in aging and in age-related disorders (for example, neurodegenerative diseases and diabetes). AR7 working as a chemical enhancement of CMA protects cells from oxidative stress and from proteotoxicity, and supports a potential therapeutic opportunity when reduced CMA contributes to cellular dysfunction and disease. AR7 is the first chemical compound that affects CMA has the selectivity for this pathway without affecting macroautophagy.


How to Use:

In vitro:  AR7 was suggested to be used at 5-20 µM final concentration in vitro and in cellular assays.

In vivo:  n/a


Reference:

  1. 1. Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. (2013) Nat Chem Biol. 9(6):374-82.

   AR7_spec.pdf

   AR7_MSDS.pdf 


Products are for research use only. Not for human use. 

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