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Hedgehog pathway

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  1. Cilliobrevin D, AAA+ ATPase Motor Cytoplasmic Dynein Inhibitor

    $139.00
    Catalog No. M60041-2s
    A novel and specific inhibitor of the AAA+ ATPase motor cytoplasmic dynein; perturbs protein trafficking within the primary cilium and affects other dynein-dependent processes, such as spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation and peroxisome motility in cultured cells.
  2. Cyclopamine, Hedgehog Antagonist

    $79.00
    Catalog No. M60022
    A potent natural product of Hedgehog antagonist; directly binding to the Smoothened/Smo.
  3. GDC-0449 (Vismodegib), Hedgehog Antagonist

    $79.00
    Catalog No. M60034
    A potent and specific hedgehog pathway inhibitor approved by FDA
  4. Hh-Ag1.5, Hedgehog Agonist

    $139.00
    Catalog No. M60004
    The most potent and selective agonist of the Hh pathway (Smoothened/Smo agonist); could replace the recombinant Hh protein to activate the Hh pathway
  5. JK184, Hedgehog Antagonist

    $79.00
    Catalog No. M60087
    A potent and cell-permeable inhibitor of hedgehog (Hh) signaling downstream of Smo.
  6. LDE225, Hedgehog Antagonist

    $99.00
    Catalog No. M60013
    A potent and specific Hedgehog pathway inhibitor (Smo antagonist) in clinical trials.
  7. Purmorphamine, Hedgehog Agonist

    $99.00
    Catalog No. M66055
    A selective hedgehog pathway agonist (Smo agonist).
  8. RU-SKI 43, Hhat Inhibitor

    $139.00
    Catalog No. M60100
    The first potent and specific small molecule inhibitor of Hedgehog acyltransferase (Hhat).
  9. SAG, Hedgehog Agonist

    $129.00
    Catalog No. M60081
    A potent, selective, and cell-permeable small-molecule agonist of the Hedgehog pathway.
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