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Neurogenic

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  1. BMS-708163 (Avagacestat), γ-Secretase Inhibitor

    $89.00
    Catalog No. M60032
    A potent γ-secretase Inhibitor, more selective for APP than Notch, in clinical trials for Alzheimer's disease.
  2. C646, p300/CBP inhibitor

    $129.00
    Catalog No. M60129
    A potent, selective and cell-permeable p300/CBP histone acetyltransferase (HAT) inhibitor.
  3. CTEP, mGlu5 Antagonist

    $259.00
    Catalog No. M60099
    A highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor.
  4. DAPT, γ-secretase Inhibitor

    $300.00
    Catalog No. M60023
    A γ-secretase inhibitor and widely used as a Notch pathway inhibitor.
  5. HG-10-102-01, LRRK2 Inhibitor

    $139.00
    Catalog No. M60061
    A brain penetrant potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant.
  6. ISRIB (trans-isomer), Inhibitor of “Integrated Stress Response” (ISR)

    $129.00
    Catalog No. M60125
    A potent and selective small molecule inhibitor of PERK signaling that can potently reverse the effects of eIF2α phosphorylation, Inhibitor of “Integrated Stress Response” (ISR).
  7. ISX9, Neurogenic Modulator

    $99.00
    Catalog No. M60274
    A neurogenic modulator.
  8. J147, Neuroprotective Small Molecule

    $89.00
    Catalog No. M60012
    A potent and orally active neurotrophic molecule with broadly neuroprotective efficacy in vitro and in vivo.
  9. KL001, Cryptochrome Activator

    $79.00
    Catalog No. M66044
    A novel small molecule specifically interacting with cryptochrome (CRY) and causing lengthening of the circadian period.
  10. LY411575, γ-secretase Inhibitor

    $119.00
    Catalog No. M60078
    A highly potent, selective, and orally bioavailable inhibitor of gamma secretase.
  11. Methoxy-X04, Fluorescent Amyloid β (Aβ) Probe

    $79.00
    Catalog No. M60135
    A fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid with good specificity.
  12. ML141, Cdc42 GTPase Inhibitor

    $109.00
    Catalog No. M60134
    A potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase.
  13. NAB2, Rsp5/Nedd4 pathway activator, rescuing α-synuclein toxicity

    $129.00
    Catalog No. M60153
    A novel and highly potent small molecule Rsp5/Nedd4 pathway activator that was shown to strongly and selectively protect diverse cell types from α-synuclein toxicity.
  14. NVS-SM1, SMN2 Splicing Modulator

    $129.00
    Catalog No. M60277
    A highly potent, selective and orally active small molecule SMN2 splicing modulator enhancing SMN exon 7 inclusion.
  15. Optovin, TRPA1 Activator

    $129.00
    Catalog No. M60103
    A potent and selective small molecule activator of human TRPA1.
  16. P7C3, Neuroprotective Small Molecule

    $119.00
    Catalog No. M60017
    A neuroprotective small molecule with favorable in vivo PK; protects newborn neurons from apoptosis.
  17. RG2833 (RGFP109), Brain-penetrant HDAC Inhibitor

    $69.00
    Catalog No. M60225
    A potent and selective brain-penetrant HDAC inhibitor HDAC1 and HDAC3.
  18. RGFP966, HDAC3 Inhibitor

    $89.00
    Catalog No. M60156
    RGFP966 is a potent and selective HDAC3 inhibitor.
  19. RN-1, LSD1 Inhibitor

    $109.00
    Catalog No. M60169
    RN-1 is a potent, specific and brain-penetrant Lysine Specific Demethylase-1 (LSD1) inhibitor.
  20. SAG, Hedgehog Agonist

    $129.00
    Catalog No. M60081
    A potent, selective, and cell-permeable small-molecule agonist of the Hedgehog pathway.
  21. SGC-CBP30, p300/CBP Bromodomain Inhibitor

    $139.00
    Catalog No. M60138
    SGC-CBP30 is a highly potent and selective p300/CBP bromodomain inhibitor
  22. SR10067, REV-ERB Agonist

    $129.00
    Catalog No. M60240
    A potent and specific synthetic REV-ERB agonist.
  23. SR9009, REV-ERB Agonist

    $109.00
    Catalog No. M60236
    A potent and specific synthetic REV-ERB agonist.
  24. SR9011, REV-ERB Agonist

    $109.00
    Catalog No. M66049
    A potent synthetic REV-ERB agonist with in vivo activity; can regulate circadian behavior and metabolism.
  25. TCID, Ubiquitin C-terminal Hydrolase-L3 (UCH-L3) Inhibitor

    $99.00
    Catalog No. M60197
    A novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L3 (UCH-L3)
  26. TMP269, Class IIa HDAC Inhibitor

    $129.00
    Catalog No. M60119
    A highly potent, selective and cell-permeable class IIa HDAC inhibitor.
  27. ZCL278---Cdc42 GTPase Inhibitor

    $119.00
    Catalog No. M60133
    A potent and selective inhibitor of Cdc42 GTPase.
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