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Items 1 to 27 of 27 total

  1. BMS-708163 (Avagacestat), γ-Secretase Inhibitor

    Catalog No. M60032
    A potent γ-secretase Inhibitor, more selective for APP than Notch, in clinical trials for Alzheimer's disease.
  2. C646, p300/CBP inhibitor

    Catalog No. M60129
    A potent, selective and cell-permeable p300/CBP histone acetyltransferase (HAT) inhibitor.
  3. CTEP, mGlu5 Antagonist

    Catalog No. M60099
    A highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor.
  4. DAPT, γ-secretase Inhibitor

    Catalog No. M60023
    A γ-secretase inhibitor and widely used as a Notch pathway inhibitor.
  5. HG-10-102-01, LRRK2 Inhibitor

    Catalog No. M60061
    A brain penetrant potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant.
  6. ISRIB (trans-isomer), Inhibitor of “Integrated Stress Response” (ISR)

    Catalog No. M60125
    A potent and selective small molecule inhibitor of PERK signaling that can potently reverse the effects of eIF2α phosphorylation, Inhibitor of “Integrated Stress Response” (ISR).
  7. ISX9, Neurogenic Modulator

    Catalog No. M60274
    A neurogenic modulator.
  8. J147, Neuroprotective Small Molecule

    Catalog No. M60012
    A potent and orally active neurotrophic molecule with broadly neuroprotective efficacy in vitro and in vivo.
  9. KL001, Cryptochrome Activator

    Catalog No. M66044
    A novel small molecule specifically interacting with cryptochrome (CRY) and causing lengthening of the circadian period.
  10. LY411575, γ-secretase Inhibitor

    Catalog No. M60078
    A highly potent, selective, and orally bioavailable inhibitor of gamma secretase.
  11. Methoxy-X04, Fluorescent Amyloid β (Aβ) Probe

    Catalog No. M60135
    A fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid with good specificity.
  12. ML141, Cdc42 GTPase Inhibitor

    Catalog No. M60134
    A potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase.
  13. NAB2, Rsp5/Nedd4 pathway activator, rescuing α-synuclein toxicity

    Catalog No. M60153
    A novel and highly potent small molecule Rsp5/Nedd4 pathway activator that was shown to strongly and selectively protect diverse cell types from α-synuclein toxicity.
  14. NVS-SM1, SMN2 Splicing Modulator

    Catalog No. M60277
    A highly potent, selective and orally active small molecule SMN2 splicing modulator enhancing SMN exon 7 inclusion.
  15. Optovin, TRPA1 Activator

    Catalog No. M60103
    A potent and selective small molecule activator of human TRPA1.
  16. P7C3, Neuroprotective Small Molecule

    Catalog No. M60017
    A neuroprotective small molecule with favorable in vivo PK; protects newborn neurons from apoptosis.
  17. RG2833 (RGFP109), Brain-penetrant HDAC Inhibitor

    Catalog No. M60225
    A potent and selective brain-penetrant HDAC inhibitor HDAC1 and HDAC3.
  18. RGFP966, HDAC3 Inhibitor

    Catalog No. M60156
    RGFP966 is a potent and selective HDAC3 inhibitor.
  19. RN-1, LSD1 Inhibitor

    Catalog No. M60169
    RN-1 is a potent, specific and brain-penetrant Lysine Specific Demethylase-1 (LSD1) inhibitor.
  20. SAG, Hedgehog Agonist

    Catalog No. M60081
    A potent, selective, and cell-permeable small-molecule agonist of the Hedgehog pathway.
  21. SGC-CBP30, p300/CBP Bromodomain Inhibitor

    Catalog No. M60138
    SGC-CBP30 is a highly potent and selective p300/CBP bromodomain inhibitor
  22. SR10067, REV-ERB Agonist

    Catalog No. M60240
    A potent and specific synthetic REV-ERB agonist.
  23. SR9009, REV-ERB Agonist

    Catalog No. M60236
    A potent and specific synthetic REV-ERB agonist.
  24. SR9011, REV-ERB Agonist

    Catalog No. M66049
    A potent synthetic REV-ERB agonist with in vivo activity; can regulate circadian behavior and metabolism.
  25. TCID, Ubiquitin C-terminal Hydrolase-L3 (UCH-L3) Inhibitor

    Catalog No. M60197
    A novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L3 (UCH-L3)
  26. TMP269, Class IIa HDAC Inhibitor

    Catalog No. M60119
    A highly potent, selective and cell-permeable class IIa HDAC inhibitor.
  27. ZCL278---Cdc42 GTPase Inhibitor

    Catalog No. M60133
    A potent and selective inhibitor of Cdc42 GTPase.
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