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Small Molecules

For our customers’ convenience, we provide ready-to-use sterile compound solution at 10 mM stock concentration dissolved in anhydrous pure and biological-grade DMSO. Our QC lab independently tests every batch of compounds to make sure their high purity by LC/MS and NMR. The DMSO stock solutions are further tested in cell culture to ensure there is no undesired activity. Our partner labs have also functionally tested our new compounds to ensure their activity before we offer them for the first time to the research community.
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  1. AGI-5198 (IDH-C35), Mutant IDH1 Inhibitor

    Catalog No. M60068
    The first highly potent and selective mutant IDH1 inhibitor that was shown to have anti-tumor efficacy in vivo.
  2. AGI-6780, Mutant IDH2 Inhibitor

    Catalog No. M60105
    The first highly potent and selective small molecule mutant IDH2 inhibitor.
  3. AK-7, SIRT2 Inhibitor

    Catalog No. M60107
    A cell- and brain-permeable, selective sirtuin SIRT2 inhibitor, displays no effect on SIRT1 or SIRT3.
  4. AMI-1, Histone Methyltransferase Inhibitor

    Catalog No. M60272
    A potent and specific small molecule inhibitor of histone methyltransferase targeting yeast Hmt1p and human PRMT1.
  5. APY29, IRE1a Modulator

    Catalog No. M60168
    A highly potent and selective small molecule modulator of IRE1α.
  6. AR7, RARα antagonist

    Catalog No. M60116
    A highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RARα.
  7. AS2034178, GPR40 Agonist

    Catalog No. M60221
    A potent, selective and orally bioavailable GPR40 (FFA1) agonist.
  8. AS8351, KDM5B Inhibitor

    Catalog No. M60330
    A potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B).
  9. Atglistatin, Adipose Triglyceride Lipase (ATGL) Inhibitor

    Catalog No. M60150
    A highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL).
  10. AZD2014, mTOR Inhibitor

    Catalog No. M60090
    A highly potent, selective and ATP-competitive mTOR inhibitor with a high level of selectivity against other members of the PIKK family.
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