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Small Molecules


For our customers’ convenience, we provide ready-to-use sterile compound solution at 10 mM stock concentration dissolved in anhydrous pure and biological-grade DMSO. Our QC lab independently tests every batch of compounds to make sure their high purity by LC/MS and NMR. The DMSO stock solutions are further tested in cell culture to ensure there is no undesired activity. Our partner labs have also functionally tested our new compounds to ensure their activity before we offer them for the first time to the research community.
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Items 1 to 318 of 318 total

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  1. Nocodazole, Microtubule Inhibitor / CRISPR Editing Enhancer

    $79.00
    Catalog No. M60331
    A potent microtubule inhibitor to inhibit mitosis and CRISPR editing enhancer.
  2. (+)-JQ1, BET Inhibitor

    $109.00   $139.00
    Catalog No. M60139
    A potent and selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4
  3. (R)-2-HG, a-KG-dependent dioxygenases inhibitor

    $69.00
    Catalog No. M60104
    An a-KG-dependent dioxygenases inhibitor
  4. (S)-crizotinib, MTH1 Inhibitor

    $99.00
    Catalog No. M60208
    A novel potent, selective and cell permeable MTH1 inhibitor.
  5. (Z)-4-Hydroxytamoxifen, CRISPR Editing Enhancer

    $89.00
    Catalog No. M60324
    Previously characterized as an Estrogen Receptor antagonist and now found to improve genome-editing specificity in CRISPR-mediated gene editing
  6. 1,4-DPCA, Prolyl 4-hydroxylase (P4H) Inhibitor

    $29.00
    Catalog No. M60288
    A selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor.
  7. 1-methyl-D-tryptophan (D-1MT), IDO Inhibitor

    $29.00
    Catalog No. M60291
    A potent and selective indoleamine 2,3-dioxygenase (IDO) inhibitor.
  8. 4SC-202, HDAC/LSD1 Dual Inhibitor

    $109.00
    Catalog No. M60230
    A potent, selective and orally bioavailable HDAC/LSD1 dual Inhibitor.
  9. 5-Azacytidine, DNA Methyltransferase Inhibitor

    $59.00
    Catalog No. M60131
    A classic DNA methyltransferase inhibitor, incorporates into DNA forming covalent adducts with cellular DNMT, depleting enzyme activity.
  10. A-366, G9a/GLP HMTase Inhibitor

    $139.00
    Catalog No. M60210
    A novel highly potent, selective and cell permeable G9a/GLP histone lysine methyltransferase inhibitor.
  11. A01, Smurf1 E3 Ubiquitin Ligase Inhibitor

    $109.00
    Catalog No. M60249
    A potent and selective Smurf1 E3 ubiquitin ligase inhibitor.
  12. A769662, AMPK Activator

    $79.00
    Catalog No. M60020
    A potent allosteric AMPK activator.
  13. A83-01, TGF-β Inhibitor

    $59.00
    Catalog No. M60021
    A potent and selective TGF-β pathway inhibitor (targeting ALK4, ALK5 and ALK7).
  14. AA92593, Antagonist of Melanopsin-mediated Photo-transduction

    $139.00
    Catalog No. M60143
    A potent and selective small molecule antagonist of melanopsin-mediated photo-transduction.
  15. Abiraterone, CYP17 inhibitor Abiraterone (CB-7598)

    $69.00
    Catalog No. M60031
    A first-in-class CYP17 inhibitor approved to treat castration-resistant prostate cancer.
  16. ABT-199, BCL-2 inhibitor

    $99.00
    Catalog No. M60075
    A potent BCL-2–selective (BCL-X L) inhibitor with clinical efficacy.
  17. ACY-1215 (Rocilinostat), HDAC6 inhibitor

    $109.00
    Catalog No. M60076
    A highly potent, selective, and orally bioavailable inhibitor of histone deacetylase 6 (HDAC6).
  18. AdipoRon, Adiponectin Receptor/AdipoR agonist

    $129.00
    Catalog No. M60152
    A novel, highly potent, selective and orally active small molecule agonist of adiponectin receptor (AdipoR).
  19. AG-120 (Ivosidenib), IDH1 Inhibitor

    $129.00
    Catalog No. M60318
    A potent, selective and reversible inhibitor of IDH1 in clinical trials.
  20. AG-221 (Enasidenib), IHD2 Inhibitor

    $129.00
    Catalog No. M60296
    A potent and selective inhibitor of IDH2 R140Q mutant.
  21. AGI-5198 (IDH-C35), Mutant IDH1 Inhibitor

    $109.00
    Catalog No. M60068
    The first highly potent and selective mutant IDH1 inhibitor that was shown to have anti-tumor efficacy in vivo.
  22. AGI-6780, Mutant IDH2 Inhibitor

    $109.00
    Catalog No. M60105
    The first highly potent and selective small molecule mutant IDH2 inhibitor.
  23. AK-7, SIRT2 Inhibitor

    $69.00
    Catalog No. M60107
    A cell- and brain-permeable, selective sirtuin SIRT2 inhibitor, displays no effect on SIRT1 or SIRT3.
  24. AMI-1, Histone Methyltransferase Inhibitor

    $79.00
    Catalog No. M60272
    A potent and specific small molecule inhibitor of histone methyltransferase targeting yeast Hmt1p and human PRMT1.
  25. APY29, IRE1a Modulator

    $109.00
    Catalog No. M60168
    A highly potent and selective small molecule modulator of IRE1α.
  26. AR7, RARα antagonist

    $129.00
    Catalog No. M60116
    A highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RARα.
  27. AS2034178, GPR40 Agonist

    $139.00
    Catalog No. M60221
    A potent, selective and orally bioavailable GPR40 (FFA1) agonist.
  28. AS8351, KDM5B Inhibitor

    $109.00
    Catalog No. M60330
    A potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B).
  29. Atglistatin, Adipose Triglyceride Lipase (ATGL) Inhibitor

    $119.00
    Catalog No. M60150
    A highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL).
  30. AZD2014, mTOR Inhibitor

    $169.00
    Catalog No. M60090
    A highly potent, selective and ATP-competitive mTOR inhibitor with a high level of selectivity against other members of the PIKK family.
  31. AZD6244 (Selumetinib), MEK Inhibitor

    $109.00
    Catalog No. M60067
    A potent and highly selective non-ATP competitive MEK inhibitor in clinical trials.
  32. AZD8055, mTOR Inhibitor

    $69.00
    Catalog No. M60091
    A highly potent, selective and ATP-competitive mTOR inhibitor with >1,000-fold selectivity against all PI3K isoforms.
  33. Azidothymidine (AZT), Reverse Transcriptase Inhibitor

    $29.00
    Catalog No. M60238
    A selective, orally bioavailable and brain penetrant reverse transcriptase inhibitor.
  34. b-AP15 (NSC687852), Deubiquitinases Inhibitor

    $89.00
    Catalog No. M60251
    A potent and selective deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage.
  35. BAF312, S1P1/5 Selective Agonist

    $129.00
    Catalog No. M60039
    A potent and selective sphingosine 1-phosphate (S1P1/5) receptor agonist in clinical trials.
  36. BAM7, BAX Activator

    $109.00
    Catalog No. M60069
    The first potent and selective small molecule activator of BAX, which is a pro-apoptotic BCL-2 family member.
  37. BAY 87-2243, Hypoxia-inducible Factor-1 (HIF-1) Inhibitor

    $119.00
    Catalog No. M60217
    A highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.
  38. BAY11-7082, E2 Ubiquitin Conjugating Enzyme Inhibitor

    $89.00
    Catalog No. M60309
    A potent and selective E2 ubiquitin (Ub) conjugating enzyme inhibitor.
  39. BAZ2-ICR, BAZ2 Bromodomain Inhibitor

    $129.00
    Catalog No. M60226
    A potent and selective BAZ2 bromodomain inhibitor.
  40. BETP, GLP-1R Potentiator

    $129.00
    Catalog No. M60196
    A positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor.
  41. BG45, HDAC3 Inhibitor

    $59.00
    Catalog No. M60266
    A potent, selective and cell permeable HDAC3 inhibitor.
  42. BI-2536, PLK1 and BRD4 Dual Inhibitor

    $119.00
    Catalog No. M60171
    BI-2536 is a potent inhibitor of PLK1 (Polo-like kinase 1) and BRD4 in clinical trials.
  43. BI-7273, BRD9 Bromodomain Inhibitor

    $129.00
    Catalog No. M60322
    A potent, selective and cell-permeable BRD9 inhibitor.
  44. BI-9564, BRD9 Bromodomain Inhibitor

    $129.00
    Catalog No. M60323
    A potent, selective and cell-permeable BRD9 inhibitor.
  45. BIBW2992(Afatinib), EGFR Inhibitor

    $109.00
    Catalog No. M60065-5s
    A potent and selective irreversible inhibitor of EGFR/HER2 in clinical trials.
  46. Bioymifi, TRAIL Receptor DR5 Activator

    $109.00
    Catalog No. M60088
    A potent and selective small molecule agonist of DR5.
  47. BIX-01294, G9a/GLP HMTase Inhibitor

    $79.00
    Catalog No. M60216
    A potent and selective G9a and GLP histone lysine methyltransferase inhibitor.
  48. BMS-708163 (Avagacestat), γ-Secretase Inhibitor

    $89.00
    Catalog No. M60032
    A potent γ-secretase Inhibitor, more selective for APP than Notch, in clinical trials for Alzheimer's disease.
  49. BQU57, GTPase Ral Inhibitor

    $139.00
    Catalog No. M60228
    A potent and selective GTPase Ral Inhibitor
  50. BRD9757, HDAC6 Inhibitor

    $129.00
    Catalog No. M60117
    A highly potent and selective HDAC6 inhibitor.
  51. Bromosporine, Pan-bromodomain Inhibitor

    $129.00
    Catalog No. M60144
    A broad spectrum inhibitor for bromodomains.
  52. C646, p300/CBP inhibitor

    $129.00
    Catalog No. M60129
    A potent, selective and cell-permeable p300/CBP histone acetyltransferase (HAT) inhibitor.
  53. Carfilzomib, Proteasome Inhibitor

    $109.00
    Catalog No. M60109
    A selective, irreversible proteasome inhibitor.
  54. CASIN, Cdc42 Inhibitor

    $139.00
    Catalog No. M60040
    A novel and potent inhibitor of Cdc42; was shown to rescue HSC aging phenotype and promote HSC transplantation efficiency.
  55. CAY10603, HDAC6 Inhibitor

    $129.00
    Catalog No. M60234
    A potent and selective HDAC6 inhibitor.
  56. CB-5083, p97 AAA ATPase Inhibitor

    $129.00
    Catalog No. M60306
    A highly potent, selective and orally bioavailable p97 AAA ATPase inhibitor.
  57. CHIR99021, GSK3β Inhibitor

    $390.00
    Catalog No. M60002
    The most widely used, potent and selective GSK3β Inhibitor; Wnt pathway activator.
  58. CI994 (Tacedinaline), HDAC Inhibitor

    $59.00
    Catalog No. M60186
    A potent, selective and orally active histone deacetylase (HDAC) inhibitor targeting HDAC1, HDAC2 and HDAC3.
  59. Cilliobrevin D, AAA+ ATPase Motor Cytoplasmic Dynein Inhibitor

    $139.00
    Catalog No. M60041-2s
    A novel and specific inhibitor of the AAA+ ATPase motor cytoplasmic dynein; perturbs protein trafficking within the primary cilium and affects other dynein-dependent processes, such as spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation and peroxisome motility in cultured cells.
  60. CP-690550, JAK Inhibitor

    $79.00
    Catalog No. M60033
    A potent and selective pan-JAK Inhibitor in clinical trials for rheumatoid arthritis.
  61. CPI-169, EZH2 Methyltransferase Inhibitor

    $129.00
    Catalog No. M60275
    A highly potent and selective small molecule inhibitor of histone methyltransferase EZH2.
  62. CPI-455, KDM5 Demethylases Inhibitor

    $129.00
    Catalog No. M60326
    A potent and selective KDM5A inhibitor.
  63. CPI203, BET Inhibitor

    $139.00
    Catalog No. M60124
    A novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4, inhibiting Myc expression.
  64. CRISPR Editing Tool Box

    $499.00
    Catalog No. LI30010
    Compound collection for CRISPR editing.
  65. CTEP, mGlu5 Antagonist

    $259.00
    Catalog No. M60099
    A highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor.
  66. CUDC-101, HDAC/EGFR/HER2 Inhibitor

    $69.00
    Catalog No. M60092
    A potent multi-target inhibitor targeting HDAC, EGFR and HER2 in clinical trial.
  67. CUDC-907, PI3K/HDAC dual inhibitor

    $139.00
    Catalog No. M60077
    A potent dual inhibitor of class I PI3K kinases and HDACs in clinical trials.
  68. CX-4945, CK2 (Casein Kinase 2) Inhibitor

    $129.00
    Catalog No. M60267
    A potent, selective and bioavailable CK2 (Casein Kinase 2) Inhibitor.
  69. CX-5461, RNA Polymerase I inhibitor

    $149.00
    Catalog No. M66052
    A potent and selective RNA Polymerase I inhibitor, for anti-tumor use.
  70. Cyclopamine, Hedgehog Antagonist

    $79.00
    Catalog No. M60022
    A potent natural product of Hedgehog antagonist; directly binding to the Smoothened/Smo.
  71. Cyclosporin A, MPTP Inhibitor and HSC Protector

    $39.00
    Catalog No. M60262
    An inhibitor of the mitochondrial permeability transition pore (MPTP).
  72. Daidzein-2c, Osteogenic Modulator

    $109.00
    Catalog No. M60158
    A potent synthetic daidzein analog with osteogenic induction potentials on human Mesenchymal Stem Cells (MSC).
  73. Daminozide --- KDM2/7 Histone Demethylases Inhibitor

    $69.00
    Catalog No. M60074
    A potent and selective small molecule inhibitor of the KDM2/7 family of human JmjC histone demethylases.
  74. DAPT, γ-secretase Inhibitor

    $300.00
    Catalog No. M60023
    A γ-secretase inhibitor and widely used as a Notch pathway inhibitor.
  75. DASA-58 (ML203), Pyruvate Kinase M2 (PKM2) Activator

    $109.00
    Catalog No. M60305
    A potent and selective Pyruvate kinase M2 (PKM2) activator.
  76. Deltarasin, KRAS-PDEδ Inhibitor

    $139.00
    Catalog No. M60218
    A potent and selective small molecular inhibitor of KRAS-PDEδ interaction
  77. DMOG, Prolyl 4-hydroxylase (P4H) Inhibitor

    $39.00
    Catalog No. M60287
    A selective, competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor.
  78. DMXAA (Vadimezan), mSTING Agonist

    $79.00
    Catalog No. M60301
    A potent and selective mSTING agonist, selective for mouse STING over human STING.
  79. DZNep (3-Deazaneplanocin A) --- Histone Methyltransferase Inhibitor

    $129.00
    Catalog No. M60141
    An S-adenosylhomocysteine hydrolase inhibitor, indirectly inhibiting histone methyltransferases and decreasing global DNA methylation
  80. EED226, PRC2 Inhibitor

    $139.00
    Catalog No. M60327
    A potent and selective allosteric PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED.
  81. EML425, CBP/p300 Inhibitor

    $129.00
    Catalog No. M60257
    A selective, noncompetitive and cell permeable KAT3 histone acetyltransferases CBP/p300 inhibitor.
  82. Entinostat (MS-275) -- HDAC Inhibitor

    $59.00
    Catalog No. M60174
    Entinostat (MS-275) is a potent and selective HDAC1 and HDAC3 inhibitor.
  83. EPZ-5676 --- DOT1L inhibitor

    $139.00
    Catalog No. M60123
    A highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S-adenosylmethionine.
  84. EPZ-6438, EZH2 Methyltransferase Inhibitor

    $129.00
    Catalog No. M60122
    EPZ-6438 (E7438) is a potent and selective small molecule inhibitor of histone methyltransferase EZH2 in clinical development.
  85. EPZ015666 (GSK3235025), PRMT5 Inhibitor

    $129.00
    Catalog No. M60254
    A potent, selective and orally bioavailable Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  86. EX-527, SIRT1 Inhibitor

    $69.00
    Catalog No. M60108
    EX-527 is a highly potent and selective inhibitor of SIRT1 with an IC50 ~98 nM.
  87. FASCIN-G2, Fascin Inhibitor

    $129.00
    Catalog No. M60269
    A potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin.
  88. Fatostatin A, Sterol Regulatory Binding Proteins (SREBPs) Inhibitor

    $59.00
    Catalog No. M60180
    Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs).
  89. Ferrostatin-1 (Fer-1), Ferroptosis Inhibitor

    $109.00
    Catalog No. M60042
    Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis with an EC50 ~60 nM, identified by a HTS using erastin-induced ferroptosis in HT-1080 cells.
  90. FG-4592 (Roxadustat), HIF Prolyl-Hydroxylases Inhibitor

    $39.00
    Catalog No. M60263
    A potent, selective and bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylase.
  91. FH1, Hepatocytes Functional Enhancer

    $139.00
    Catalog No. M60127
    FH1 is a potent and selective small molecule that enhances hepatocyte functions and promotes the differentiation and maturation of iPSC-derived hepatocytes toward a more mature phenotype in vitro.
  92. FLI-06, Notch Pathway Modulator

    $139.00
    Catalog No. M60149
    FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 µM), identified by using automated microscopy to monitor the trafficking and processing of a ligand-independent Notch-GFP fusion reporter.
  93. Forskolin, Adenylyl Cyclase Activator

    $79.00
    Catalog No. M60024
    A potent adenylate cyclase activator to increase the intracellular levels of cAMP.
  94. FPH1, Hepatocytes Functional Proliferation Inducer

    $139.00
    Catalog No. M60126
    FPH1 is a potent and selective small molecule that induced Functional Proliferation of primary human Hepatocytes in vitro, identified by a high-throughput, cell-based screening using primary human hepatocytes.
  95. Furamidine, PRMT1 Inhibitor

    $99.00
    Catalog No. M60256
    A potent, selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor.
  96. GDC-0068, Akt Inhibitor

    $159.00
    Catalog No. M60066
    A novel potent and selective ATP competitive Akt inhibitor in clinical trials.
  97. GDC-0349, mTOR Inhibitor

    $129.00
    Catalog No. M60110
    A potent and selective ATP-competitive inhibitor of mTOR in clinical trials.
  98. GDC-0449 (Vismodegib), Hedgehog Antagonist

    $79.00
    Catalog No. M60034
    A potent and specific hedgehog pathway inhibitor approved by FDA
  99. GDC-0941, PI3K Inhibitor

    $79.00
    Catalog No. M60111
    A highly potent, selective and orally bioavailable class-I PI3K kinase inhibitor.
  100. GN44028, HIF-1α Inhibitor

    $89.00
    Catalog No. M60325
    A potent and selective HIF-1α inhibitor.
  101. GNF-7, Ras Signaling Inhibitor

    $129.00
    Catalog No. M60281
    A potent, selective and bioavailable Ras signaling inhibitor.
  102. GNF4877, β Cell Proliferation Inducer

    $159.00
    Catalog No. M60294
    A highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets.
  103. GNF7156, β Cell Proliferation Inducer

    $139.00
    Catalog No. M60293
    A highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets.
  104. Go6893, PKC Inhibitor

    $129.00
    Catalog No. M60273
    A potent pan-PKC inhibitor.
  105. GPR39-C3, GPR39 Agonist

    $139.00
    Catalog No. M60209
    The first potent, selective and orally bioavailable GPR39 agonist.
  106. GS143, IkappaB Ubiquitination Inhibitor

    $129.00
    Catalog No. M60308
    A selective β-TrCP1 ligase inhibitor
  107. GSK-J1, H3K27 Histone Demethylases UTX and JMJD3 Inhibitor

    $109.00
    Catalog No. M60062
    The first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3.
  108. GSK-J4, H3K27 Histone Demethylases UTX and JMJD3 Inhibitor

    $109.00
    Catalog No. M60063
    An ethyl ester derivative of GSK-J1 as a pro-drug for cellular assays; the first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3.
  109. GSK-LSD1, LSD1 Inhibitor

    $139.00
    Catalog No. M60179
    A highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1).
  110. GSK126, EZH2 Methyltransferase Inhibitor.

    $129.00
    Catalog No. M60071
    GSK126 is a highly potent and selective small molecule inhibitor of histone methyltransferase EZH2.
  111. GSK2801, Bromodomain BAZ2A/B Inhibitor

    $129.00
    Catalog No. M60283
    A potent, selective and cell permeable inhibitor of the bromodomain BAZ2A and BAZ2B.
  112. GSK2879552, LSD1 Inhibitor

    $129.00
    Catalog No. M60297
    A highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1).
  113. GSK343, EZH2 Methyltransferase Inhibitor

    $79.00
    Catalog No. M60173
    GSK343 is a potent and selective small molecule inhibitor of histone methyltransferase EZH2.
  114. GSK591 (EPZ015866), PRMT5 Inhibitor

    $109.00
    Catalog No. M60321
    A potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  115. GSK5959, BRPF1 Bromodomain Inhibitor

    $129.00
    Catalog No. M60239
    A potent, selective and cell permeable BRPF1 bromodomain inhibitor.
  116. Harmine, DYRK1A Inhibitor

    $29.00
    Catalog No. M60241
    A potent, selective and orally bioavailable DYRK1A inhibitor.
  117. HBX41108, USP7 Inhibitor

    $129.00
    Catalog No. M60244
    A potent and selective ubiquitin-specific protease 7 (USP7) inhibitor.
  118. HCI-2509 (SP2509), Reversible LSD1 Inhibitor.

    $109.00
    Catalog No. M60160
    A highly potent, specific, and reversible Lysine Specific Demethylase-1 (LSD1) inhibitor with in vivo efficacy.
  119. Heclin, HECT E3 Ubiquitin Ligase Inhibitor

    $89.00
    Catalog No. M60248
    A selective HECT E3 ubiquitin ligase inhibitor to inhibit Nedd4, Smurf2 and WWP1.
  120. HG-10-102-01, LRRK2 Inhibitor

    $139.00
    Catalog No. M60061
    A brain penetrant potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant.
  121. Hh-Ag1.5, Hedgehog Agonist

    $139.00
    Catalog No. M60004
    The most potent and selective agonist of the Hh pathway (Smoothened/Smo agonist); could replace the recombinant Hh protein to activate the Hh pathway
  122. HIF-C2, HIF-2 Inhibitor

    $139.00
    Catalog No. M60121
    A potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2).
  123. HLCL-61, PRMT5 Inhibitor

    $109.00
    Catalog No. M60320
    A potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  124. HLY78, Wnt Activator

    $149.00
    Catalog No. M60140
    An activator of the Wnt pathway by targeting the DIX domain of Axin and potentiating the Axin–LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction.
  125. HPOB, HDAC6 Inhibitor

    $79.00
    Catalog No. M60231
    A potent and selective HDAC6 inhibitor.
  126. Hydroxychloroquine (HCQ), Autophagy and TLR9 Inhibitor

    $49.00
    Catalog No. M60302
    A potent autophagy inhibitor and TLR9 inhibitor
  127. I-BET151 (GSK1210151A), BET Inhibitor

    $109.00
    Catalog No. M66053
    A potent and selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4.
  128. I-BET762 (GSK525762), BET Inhibitor

    $139.00
    Catalog No. M60154
    A novel, highly potent, selective and cell permeable BET inhibitor in clinical trials.
  129. I-BRD9, Bromodomain Containing Protein 9 (BRD9) Inhibitor

    $129.00
    Catalog No. M60276
    A potent, selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor.
  130. I-CBP112, p300/CBP Bromodomain Inhibitor

    $139.00
    Catalog No. M60128
    A highly potent and selective p300/CBP bromodomain inhibitor.
  131. ID-8, DYRK Inhibitor

    $89.00
    Catalog No. M60102
    A potent and selective small molecule inhibitor of dual-specificity tyrosine phosphorylation- regulated kinase (DYRK).
  132. IDH-C227, IDH1 Inhibitor

    $139.00
    Catalog No. M60043
    A potent and selective inhibitor of the IDH1 R132H mutant with good cellular activity.
  133. IDH2-C100, IHD2 Inhibitor

    $129.00
    Catalog No. M60190
    A potent and selective inhibitor of IDH2 R140Q and R172K mutant.
  134. INCB024360 (Epacadostat), IDO Inhibitor

    $109.00
    Catalog No. M60292
    A potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor.
  135. INDY, DYRK1A/B Inhibitor

    $79.00
    Catalog No. M60242
    A potent and selective DYRK1A/B inhibitor.
  136. IOX1, 2OG Oxygenases Inhibitor

    $109.00
    Catalog No. M60195
    A cell-permeable broad-spectrum inhibitor of most 2OG oxygenases.
  137. IOX2, HIF Prolyl-Hydroxylases (PHD2) Inhibitor

    $89.00
    Catalog No. M66054
    A potent and selective PHD (HIF prolyl-hydroxylases) inhibitor with cellular activity.
  138. IOX4, PHD2 Inhibitor

    $109.00
    Catalog No. M60284
    A potent and selective PHD2 inhibitor.
  139. IRE-3, IRE1a Modulator

    $129.00
    Catalog No. M60167
    A highly potent and selective small molecule modulator of IRE1α.
  140. Ischemin, CBP Bromodomain Inhibitor

    $79.00
    Catalog No. M60229
    A potent, selective and cell permeable CBP bromodomain inhibitor.
  141. ISRIB (trans-isomer), Inhibitor of “Integrated Stress Response” (ISR)

    $129.00
    Catalog No. M60125
    A potent and selective small molecule inhibitor of PERK signaling that can potently reverse the effects of eIF2α phosphorylation, Inhibitor of “Integrated Stress Response” (ISR).
  142. ISX9, Neurogenic Modulator

    $99.00
    Catalog No. M60274
    A neurogenic modulator.
  143. ITD-1, TGFβ inhibitor

    $139.00
    Catalog No. M60060
    A highly selective TGFβ inhibitor promotes cardiomyogenesis in embryonic stem cells.
  144. IU1, Proteasome USP14 Inhibitor

    $49.00
    Catalog No. M60203
    A cell-permeable, reversible and selective inhibitor of human proteasome USP14.
  145. IWP-2, Porcupine (Wnt) Inhibitor

    $79.00
    Catalog No. M60115
    A potent and highly selective Wnt signaling antagonist targeting porcupine.
  146. J147, Neuroprotective Small Molecule

    $89.00
    Catalog No. M60012
    A potent and orally active neurotrophic molecule with broadly neuroprotective efficacy in vitro and in vivo.
  147. JIB-04 (NSC693627), Jumonji Histone Demethylase Inhibitor

    $119.00
    Catalog No. M60132
    A potent, selective and cell permeable Jumonji histone demethylase inhibitor, not a competitive inhibitor of a-ketoglutarate.
  148. JK184, Hedgehog Antagonist

    $79.00
    Catalog No. M60087
    A potent and cell-permeable inhibitor of hedgehog (Hh) signaling downstream of Smo.
  149. JNJ-42041935, HIF-PHD Inhibitor

    $129.00
    Catalog No. M60285
    A potent and selective HIF-PHD inhibitor.
  150. Kartogenin (KGN), Chondrogenesis Modulator

    $79.00
    Catalog No. M60027
    Selectively promote chondrocyte differentiation of human mesenchymal stem cells.
  151. KDM5-C49, JARID1 Histone Demethylases Inhibitor

    $139.00
    Catalog No. M60191
    A potent and selective inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases
  152. KDM5-C70, JARID1 Histone Demethylases Inhibitor

    $139.00
    Catalog No. M60192
    An ethyl ester derivative of KDM5-C49, which is a potent and selective inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases.
  153. KL001, Cryptochrome Activator

    $79.00
    Catalog No. M66044
    A novel small molecule specifically interacting with cryptochrome (CRY) and causing lengthening of the circadian period.
  154. KRAS-C9, K-Ras(G12C) Inhibitor

    $139.00
    Catalog No. M60219
    A potent and selective allosteric inhibitor of oncogenic K-Ras(G12C).
  155. KY02111, Wnt Inhibitor

    $109.00
    Catalog No. M60073
    A potent and selective Wnt inhibitor promotes differentiation of hESCs/iPSCs to cardiomyocytes; might function downstream from GSK3β and APC in b-catenin destruction complex
  156. KYA1797K, Wnt/β-catenin Inhibitor

    $129.00
    Catalog No. M60317
    A highly potent and selective Wnt/β-catenin inhibitor binding directly to the regulators of G-protein signaling domain of axin.
  157. L002 (NSC764414), p300 Inhibitor

    $99.00
    Catalog No. M60198
    A novel selective, cell permeable and reversible inhibitor of p300 histone acetyl transferase.
  158. L755,507, CRISPR Editing Enhancer

    $89.00
    Catalog No. M60237
    CRISPR editing enhancer to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
  159. LDE225, Hedgehog Antagonist

    $99.00
    Catalog No. M60013
    A potent and specific Hedgehog pathway inhibitor (Smo antagonist) in clinical trials.
  160. LDN-193189, BMP inhibitor

    $79.00
    Catalog No. M60008
    A highly potent and selective BMP pathway inhibitor (selective for ALK2 and ALK3); can replace Noggin protein in cellular and in vivo use.
  161. LDN-57444, Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor

    $69.00
    Catalog No. M60204
    A novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1).
  162. LGK974, Porcupine (Wnt) Inhibitor

    $139.00
    Catalog No. M60106
    A highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) in clinical trials.
  163. LLY-507, Protein-lysine Methyltransferase SMYD2 Inhibitor

    $129.00
    Catalog No. M60259
    A potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor.
  164. LMK235, HDAC4 and HDAC5 Inhibitor

    $89.00
    Catalog No. M60145
    A potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor.
  165. LSD1-C76, LSD1 Inhibitor

    $159.00
    Catalog No. M66045
    The most potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor so far.
  166. LY2109761, TGFβ Inhibitor

    $109.00
    Catalog No. M60035
    A novel potent and selective TGFβ receptor type I and type II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM respectively.
  167. LY2157299, TGFβ Inhibitor

    $169.00
    Catalog No. M60064
    A novel potent and selective TGFβ receptor type I and type II (TβRI/II) inhibitor with IC50 of 86 nM and 2 nM respectively.
  168. LY2784544, JAK2 inhibitor

    $129.00
    Catalog No. M60079
    A highly potent and selective mutant JAK2 (V617F) inhibitor.
  169. LY294002, PI3K/BET Dual Inhibitor

    $79.00
    Catalog No. M60157
    A potent and selective small molecule PI3K and BET bromodomain dual inhibitor.
  170. LY411575, γ-secretase Inhibitor

    $119.00
    Catalog No. M60078
    A highly potent, selective, and orally bioavailable inhibitor of gamma secretase.
  171. MALT1-MI-2 (MI-2), MALT1 inhibitor

    $129.00
    Catalog No. M60098
    A highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function.
  172. MC1568, Class IIa HDAC Inhibitor

    $79.00
    Catalog No. M60224
    A potent and selective inhibitor of class IIa histone deacetylases (HDACs), more selective for HD1-A than HD1-B.
  173. ME0328, PARP-3 Inhibitor

    $109.00
    Catalog No. M60329
    A potent, selective and cell permeable PARP-3 inhibitor.
  174. MEK162 (ARRY-162), MEK Inhibitor

    $119.00
    Catalog No. M60080
    A highly potent, selective, and orally bioavailable MEK inhibitor in clinical trials.
  175. Methoxy-X04, Fluorescent Amyloid β (Aβ) Probe

    $79.00
    Catalog No. M60135
    A fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid with good specificity.
  176. MHY1485, mTOR Activator

    $49.00
    Catalog No. M60189
    A novel potent, selective and cell-permeable mTOR activator.
  177. MI-2, Menin-MLL Inhibitor

    $119.00
    Catalog No. M66046
    A highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function.
  178. MK-1775 (AZD1775), WEE1 Inhibitor

    $129.00
    Catalog No. M60299
    A highly potent, selective and orally bioavailable Wee1 kinase inhibitor.
  179. ML141, Cdc42 GTPase Inhibitor

    $109.00
    Catalog No. M60134
    A potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase.
  180. ML228, HIF Pathway Activator

    $129.00
    Catalog No. M60130
    A potent and selective hypoxia inducible factor (HIF) pathway activator.
  181. ML239, Breast Cancer Stem Cell Inhibitor

    $129.00
    Catalog No. M60282
    A potent and selective breast cancer stem cell inhibitor.
  182. ML323, USP1-UAF1 Inhibitor

    $139.00
    Catalog No. M60188
    A potent, selective and reversible inhibitor of the USP1-UAF1 deubiquitinase complex.
  183. ML324, JMJD2 Histone Demethylase Inhibitor

    $139.00
    Catalog No. M60183
    A potent, selective and cell permeable inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase.
  184. MLN8237 (Alisertib), Aurora A inhibitor

    $119.00
    Catalog No. M60093
    A highly potent and selective Aurora A inhibitor with >200-fold selective towards Aurora B.
  185. MM-102, WDR5-MLL1 Antagonist

    $129.00
    Catalog No. M60166
    A highly potent and selective inhibitor of the MLL1/WDR5 interaction.
  186. MRT68921, Autophagy Kinase ULK1/2 Inhibitor

    $109.00
    Catalog No. M60311
    A potent, selective and dual autophagy kinase ULK1/2 inhibitor.
  187. MS023, PRMT Inhibitor

    $109.00
    Catalog No. M60314
    A potent, selective and cell permeable type I PRMT inhibitor.
  188. MS049, PRMT4 and PRMT6 Inhibitor

    $89.00
    Catalog No. M60310
    A potent, selective and cell permeable PRMT4 and PRMT6 inhibitor.
  189. MS436, BRD4 Inhibitor

    $109.00
    Catalog No. M60232
    A potent and selective BET bromodomain inhibitor for BRD4 (1) and BRD4 (2).
  190. MSAB, β-catenin Inhibitor

    $129.00
    Catalog No. M60316
    A potent and selective Wnt/β-catenin inhibitor identified using cell-based chemical screening.
  191. N106, SERCA2a SUMOylation Activator

    $129.00
    Catalog No. M60271
    A potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a.
  192. NAB2, Rsp5/Nedd4 pathway activator, rescuing α-synuclein toxicity

    $129.00
    Catalog No. M60153
    A novel and highly potent small molecule Rsp5/Nedd4 pathway activator that was shown to strongly and selectively protect diverse cell types from α-synuclein toxicity.
  193. Napabucasin (BBI608), STAT3 Inhibitor

    $89.00
    Catalog No. M60303
    A potent and selective STAT3 inhibitor.
  194. NI-57, BRPF Bromodomain Inhibitor

    $109.00
    Catalog No. M60279
    A potent and selective inhibitor of the bromodomain of the BRPFs.
  195. NLG919 (RG6078), IDO Inhibitor

    $129.00
    Catalog No. M60258
    A potent, selective and orally bioavailable IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor.
  196. NMS-859, ATPase VCP/p97 Inhibitor

    $139.00
    Catalog No. M60148
    A potent and specific small molecule covalent inhibitor of the ATPase VCP/p97.
  197. NMS-873, ATPase VCP/p97 Inhibitor

    $139.00
    Catalog No. M60165
    A potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97.
  198. NSC319726, Mutant p53 Activator

    $89.00
    Catalog No. M66047
    A potent and selective activator of the most common p53R175 mutant, restoring the mutant p53 to its WT structure and function.
  199. NSC636819, KDM4A/KDM4B Inhibitor

    $109.00
    Catalog No. M60290
    A cell permeable and selective novel active-site KDM4A/KDM4B inhibitor.
  200. NSC697923, Ub-conjugating Enzyme (E2) Inhibitor

    $69.00
    Catalog No. M60202
    A cell permeable, potent and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.
  201. NU9056--- KAT5 (Tip60) Histone Acetyltransferase Inhibitor

    $69.00
    Catalog No. M60147
    A potent and selective KAT5 (Tip60) histone acetyltransferase inhibitor.
  202. NVP-BGT226, PI3K/mTOR Dual Inhibitor

    $89.00
    Catalog No. M66050
    A PI3K/mTOR dual inhibitor in clinical trials for advanced solid tumors.
  203. NVP-BKM120, PI3K Inhibitor BKM120

    $89.00
    Catalog No. M66051
    A selective PI3K Inhibitor in clinical trials for advanced solid tumors.
  204. NVP-TNKS656, Wnt / Tankyrase Inhibitor

    $109.00
    Catalog No. M60328
    A highly potent, selective and oral bioavailable tankyrase inhibitor for TNKS2.
  205. NVS-SM1, SMN2 Splicing Modulator

    $129.00
    Catalog No. M60277
    A highly potent, selective and orally active small molecule SMN2 splicing modulator enhancing SMN exon 7 inclusion.
  206. OAC1, Oct4 Activator

    $109.00
    Catalog No. M60086
    A potent Oct4 activator significantly enhancing iPSC reprogramming efficiency and accelerating the reprogramming process.
  207. OF-1, BRPF Bromodomain Inhibitor

    $129.00
    Catalog No. M60222
    A potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor.
  208. OG-L002, LSD1 Inhibitor

    $89.00
    Catalog No. M60161
    A highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1).
  209. OICR9429, WDR5 Antagonist

    $129.00
    Catalog No. M60255
    A potent and selective WD repeat-containing protein 5 (WDR5) antagonist.
  210. ONX-0914, Immunoproteasome Inhibitor

    $139.00
    Catalog No. M60112
    A potent and selective immunoproteasome inhibitor.
  211. Optovin, TRPA1 Activator

    $129.00
    Catalog No. M60103
    A potent and selective small molecule activator of human TRPA1.
  212. ORY-1001 (RG-6016), LSD1 Inhibitor

    $129.00
    Catalog No. M60295
    A highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) in phase I/II.
  213. OSI-027, mTOR Inhibitor

    $109.00
    Catalog No. M60113
    OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2
  214. OTX015, BET Inhibitor

    $89.00
    Catalog No. M60193
    OTX015 is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10-19 nM.
  215. P22077, USP7 inhibitor

    $99.00
    Catalog No. M60019
    A potent and selective USP7 inhibitor.
  216. P5091, Ubiquitin-specific Protease 7 (USP7) Inhibitor

    $79.00
    Catalog No. M60205
    P5091 (P005091) is a novel potent and selective inhibitor of ubiquitin-specific protease 7 (USP7)
  217. P7C3, Neuroprotective Small Molecule

    $119.00
    Catalog No. M60017
    A neuroprotective small molecule with favorable in vivo PK; protects newborn neurons from apoptosis.
  218. PBIT, JARID1 Histone Demethylases Inhibitor

    $129.00
    Catalog No. M60170
    PBIT is a potent, specific, reversible and cell-permeable inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases.
  219. PCI-34051, HDAC8 Inhibitor

    $79.00
    Catalog No. M60178
    PCI-34051 is a potent and selective inhibitor of histone deacetylase 8 (HDAC8).
  220. PD-1/PD-L1 Inhibitor C1

    $109.00
    Catalog No. M60312
    A potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions.
  221. PD0325901, MEK Inhibitor

    $69.00
    Catalog No. M60018
    A potent and selective MEK inhibitor.
  222. PF-04979064, PI3K/mTOR Dual Inhibitor

    $149.00
    Catalog No. M60114
    PF-04979064 is a highly potent and orally bioavailable PI3K/mTOR dual inhibitor developed through structure-based drug design.
  223. PF-CBP1,CBP/p300 Bromodomain Inhibitor

    $129.00
    Catalog No. M60313
    A potent and selective CBP/p300 bromodomain inhibitor.
  224. PFI-1, BET Inhibitor

    $129.00
    Catalog No. M60120
    PFI-1 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2 and BRD4.
  225. PFI-2, SETD7 Histone Lysine Methyltransferase Inhibitor

    $139.00
    Catalog No. M60182
    PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor.
  226. PFI-3, SMARCA Bromodomains Inhibitor

    $139.00
    Catalog No. M60175
    PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains.
  227. PFI-4, BRPF1 Bromodomain Inhibitor

    $129.00
    Catalog No. M60264
    A potent, selective and cell permeable BRPF1 bromodomain inhibitor.
  228. PluriSIn#1, Pluripotent Cell-specific Inhibitor

    $109.00
    Catalog No. M60085
    A potent small molecule to selectively eliminate human pluripotent stem cells/hPSCs while sparing a large array of tissue-specific stem/progenitor and differentiated cells.
  229. PP242, mTORC1/mTORC2 inhibitor

    $69.00
    Catalog No. M60094
    A highly potent, selective and ATP-competitive mTORC1/mTORC2 inhibitor.
  230. PR-619, Deubiquitinylating Enzyme (DUB) Inhibitor

    $59.00
    Catalog No. M60199
    PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs).
  231. PRMT1-2e, Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor

    $69.00
    Catalog No. M60181
    PRMT1-2e is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1).
  232. PRT4165, E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor

    $39.00
    Catalog No. M60245
    A potent and selective E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor.
  233. PS48---PDK1 Activator

    $79.00
    Catalog No. M60026
    An allosteric small molecule activator of PDK1.
  234. PTC-209, BMI-1 Inhibitor

    $129.00
    Catalog No. M60159
    PTC-209 is a novel potent and selective BMI-1 inhibitor, targeting the BMI-1 self-renewal machinery.
  235. Purmorphamine, Hedgehog Agonist

    $99.00
    Catalog No. M66055
    A selective hedgehog pathway agonist (Smo agonist).
  236. PX-478, Hypoxia-inducible Factor-1α (HIF-1α) Inhibitor

    $129.00
    Catalog No. M60227
    A highly potent and selective Hypoxia-inducible Factor-1α (HIF-1α) inhibitor.
  237. PYR-41---Ubiquitin-activating Enzyme E1 Inhibitor

    $59.00
    Catalog No. M60201
    PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1
  238. Pyrintegrin---Cell Survival Enhancer

    $109.00
    Catalog No. M60028
    A potent small molecule promoting hESC survival
  239. PYZD-4409, Ubiquitin-activating Enzyme (E1) Inhibitor

    $139.00
    Catalog No. M60213
    A novel potent, selective and cell permeable inhibitor of ubiquitin-activating enzyme (E1).
  240. RA190, Ubiquitin Receptor RPN13/ADRM1 Inhibitor

    $139.00
    Catalog No. M60163
    A novel potent and selective inhibitor of proteasome Ubiquitin receptor RPN13/ADRM1.
  241. Rapamycin, mTOR inhibitor

    $89.00
    Catalog No. M60029
    A potent and selective mTOR inhibitor, directly binding to the mTOR Complex 1 (mTORC1).
  242. Remodelin, Acetyl-transferase NAT10 Inhibitor

    $139.00
    Catalog No. M60187
    Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
  243. RepSox---TGF-β Type I Receptor ALK5 Inhibitor

    $79.00
    Catalog No. M60151
    RepSox (E-616452 or SJN 2511) is a highly potent, selective inhibitor of the TGF-β type I receptor ALK5.
  244. RG108---DNA Methyltransferase Inhibitor

    $65.00
    Catalog No. M60176
    RG108 is a potent, selective and cell permeable inhibitor of DNA methyltransferase.
  245. RG2833 (RGFP109), Brain-penetrant HDAC Inhibitor

    $69.00
    Catalog No. M60225
    A potent and selective brain-penetrant HDAC inhibitor HDAC1 and HDAC3.
  246. RGFP966, HDAC3 Inhibitor

    $89.00
    Catalog No. M60156
    RGFP966 is a potent and selective HDAC3 inhibitor.
  247. RN-1, LSD1 Inhibitor

    $109.00
    Catalog No. M60169
    RN-1 is a potent, specific and brain-penetrant Lysine Specific Demethylase-1 (LSD1) inhibitor.
  248. RO4929097, γ-Secretase Inhibitor

    $109.00
    Catalog No. M60007
    A potent and selective γ-secretase inhibitor; inhibits Notch signaling in stem cells and tumor cells.
  249. RS-1, CRISPR Editing Enhancer

    $89.00
    Catalog No. M60300
    Previously characterized as a RAD51-Stimulatory compound and now found to be an HDR enhancer to enhance CRISPR/Cas9- and TALEN-mediated knock-in efficiency
  250. RU-SKI 43, Hhat Inhibitor

    $139.00
    Catalog No. M60100
    The first potent and specific small molecule inhibitor of Hedgehog acyltransferase (Hhat).
  251. RVX-208, BET Bromodomain Inhibitor

    $59.00
    Catalog No. M60177
    RVX-208 is a potent and selective BET bromodomain inhibitor for the second bromodomain (BD2), ~170-fold selectivity over BD1.
  252. Ryuvidine, Lysine Methyltransferase SETD8 Inhibitor

    $129.00
    Catalog No. M60252
    A potent, selective and cell permeable lysine methyltransferase SETD8 inhibitor.
  253. SAG, Hedgehog Agonist

    $129.00
    Catalog No. M60081
    A potent, selective, and cell-permeable small-molecule agonist of the Hedgehog pathway.
  254. SB431542, TGF-beta Inhibitor

    $300.00
    Catalog No. M60015
    A potent and selective TGF-β pathway inhibitor (selective for ALK4, ALK5 and ALK7).
  255. SBI-0206965, Autophagy Kinase ULK1 Inhibitor

    $129.00
    Catalog No. M60268
    A potent, selective and cell permeable autophagy kinase ULK1 inhibitor.
  256. SCH51344, MTH1 Inhibitor

    $139.00
    Catalog No. M60212
    A novel potent, selective and cell permeable MTH1 inhibitor.
  257. SCR7, NHEJ inhibitor

    $129.00
    Catalog No. M60082
    A potent and selective inhibitor of non-homologous end joining (NHEJ).
  258. SD70, Histone Demethylase JMJD2 Inhibitor

    $139.00
    Catalog No. M60194
    A potent, selective and cell-permeable inhibitor of histone demethylase JMJD2 (KDM4C).
  259. Sephin1, PPP1R15A Protein Phosphatase Inhibitor

    $129.00
    Catalog No. M60280
    A potent, selective and bioavailable inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1.
  260. SGC-CBP30, p300/CBP Bromodomain Inhibitor

    $139.00
    Catalog No. M60138
    SGC-CBP30 is a highly potent and selective p300/CBP bromodomain inhibitor
  261. SGC0946, DOT1L inhibitor

    $139.00
    Catalog No. M60101
    A highly potent and selective inhibitor of DOT1L methyltransferase.
  262. SGC707, Allosteric PRMT3 Inhibitor

    $129.00
    Catalog No. M60243
    A potent, selective and cell permeable allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor.
  263. SGI-1027, DNMT Inhibitor

    $89.00
    Catalog No. M60155
    A potent and selective inhibitor of DNA methyltransferase (DNMT).
  264. SHP099, SHP2 Phosphatase Inhibitor

    $139.00
    Catalog No. M60319
    A highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor.
  265. SirReal2, Sirt2 Inhibitor

    $119.00
    Catalog No. M60289
    A potent and selective Sirt2 inhibitor.
  266. SKP2-C25, Skp2 Inhibitor

    $139.00
    Catalog No. M60136
    A potent, selective and cell permeable Skp2 inhibitor, selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes.
  267. SKPin C1, Skp2 Inhibitor

    $109.00
    Catalog No. M60137
    A potent and selective inhibitor of Skp2-mediated p27 degradation.
  268. SMER3, SCF family E3 Ubiquitin Ligase Inhibitor

    $129.00
    Catalog No. M60250
    A potent and selective a yeast SCF family E3 ubiquitin ligase inhibitor, also a small-molecule enhancers of rapamycin.
  269. Spautin-1, Autophagy Inhibitor

    $69.00
    Catalog No. M60003
    A potent autophagy inhibitor, selectively promotes the degradation of Vps34 complexes.
  270. SR10067, REV-ERB Agonist

    $129.00
    Catalog No. M60240
    A potent and specific synthetic REV-ERB agonist.
  271. SR1664,PPAR-γ Modulator

    $109.00
    Catalog No. M66048
    An unique PPARγ modulator that has potent anti-diabetic activity through blocking the Cdk5-mediated phosphorylation of PPARγ, but completely lacks classical transcriptional agonism that accounts for other PPARγ agonists’ side effects.
  272. SR9009, REV-ERB Agonist

    $109.00
    Catalog No. M60236
    A potent and specific synthetic REV-ERB agonist.
  273. SR9011, REV-ERB Agonist

    $109.00
    Catalog No. M66049
    A potent synthetic REV-ERB agonist with in vivo activity; can regulate circadian behavior and metabolism.
  274. SR9243, LXR Inverse Agonist

    $129.00
    Catalog No. M60270
    A highly potent and selective small molecule LXR inverse agonist that induces LXR-corepressor interaction.
  275. StemRegenin1 (SR1)---HSC Expansion Molecule

    $99.00
    Catalog No. M60001
    A potent and selective aryl hydrocarbon receptor antagonist; can promote robust expansion of human CD34+ hematopoietic stem and progenitor cells.
  276. SU5402---FGFR inhibitor

    $89.00
    Catalog No. M60025
    A potent and selective inhibitor of FGFR, VEGFR, and PDGFR.
  277. SW033291, 15-PGDH Inhibitor

    $99.00
    Catalog No. M60298
    A highly potent and selective inhibitor of 15-PGDH to increase prostaglandin PGE2 levels in bone marrow and other tissues.
  278. TAK-875 (Fasiglifam), GPR40 Agonist

    $139.00
    Catalog No. M60220
    A potent, selective and orally bioavailable partial GPR40 agonist.
  279. TAME, Ubiquitin Ligase APC/C Inhibitor

    $29.00
    Catalog No. M60246
    A competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C).
  280. Tasquinimod, Allosteric HDAC4 Inhibitor

    $129.00
    Catalog No. M60235
    A potent and selective allosteric HDAC4 inhibitor.
  281. TCID, Ubiquitin C-terminal Hydrolase-L3 (UCH-L3) Inhibitor

    $99.00
    Catalog No. M60197
    A novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L3 (UCH-L3)
  282. TEPP-46 (ML265), Pyruvate Kinase M2 (PKM2) Activator

    $129.00
    Catalog No. M60304
    A potent and selective Pyruvate kinase M2 (PKM2) activator.
  283. TG101348 (SAR302503), JAK2 and BRD4 Dual Inhibitor

    $109.00
    Catalog No. M60172
    TG101348 is a potent, specific and orally bioavailable inhibitor of JAK2 and BRD4 in clinical trials.
  284. TH-302, Hypoxia-activated Pro-drug

    $179.00
    Catalog No. M60089
    A highly potent and selective hypoxia-activated pro-drug targeting hypoxic regions of solid tumors.
  285. TH588, MTH1 Inhibitor

    $139.00
    Catalog No. M60211
    A novel potent, selective and cell permeable MTH1 inhibitor.
  286. Thiazovivin, Rock Inhibitor

    $79.00
    Catalog No. M60009
    A more potent and selective Rock inhibitor; can enhance hESC and hiPSC survival from single cell dissociation.
  287. THZ1, Covalent CDK7 Inhibitor

    $159.00
    Catalog No. M60214
    A novel potent, selective and cell permeable irreversible CDK7 inhibitor.
  288. TMP269, Class IIa HDAC Inhibitor

    $129.00
    Catalog No. M60119
    A highly potent, selective and cell-permeable class IIa HDAC inhibitor.
  289. TMPA---AMPK Activator

    $119.00
    Catalog No. M60072
    TMPA is a novel small molecule that binds to orphan Nuclear Receptor Nur77 and activates AMPK.
  290. TRIM24-C34, BRPF1B/TRIM24 Dual Inhibitor

    $99.00
    Catalog No. M60265
    A potent, selective and cell permeable BRPF1B and TRIM24 dual inhibitor.
  291. TZ9, Rad6 Ubiquitin Inhibitor

    $109.00
    Catalog No. M60286
    A selective and cell permeable inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B.
  292. UF010, HDAC Inhibitor

    $89.00
    Catalog No. M60278
    UF010 is a potent and selective class I HADC inhibitor.
  293. UM171, Human HSC Self-renewal Agonist

    $159.00
    Catalog No. M60223
    A potent small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice.
  294. UNC0379, Lysine Methyltransferase SETD8 Inhibitor

    $129.00
    Catalog No. M60207
    A novel selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8
  295. UNC0638, G9a HMTase Inhibitor

    $89.00
    Catalog No. M66056
    A potent, selective and cell permeable inhibitor of G9a (EHMT2) and GLP (EHMT1) histone methyltransferases.
  296. UNC0642, G9a/GLP HMTase Inhibitor

    $129.00
    Catalog No. M60185
    A novel highly potent, selective and cell permeable inhibitor of the homologous protein lysine methyltransferases, G9a and GLP, with improved PK properties.
  297. UNC0646, G9a/GLP HMTase Inhibitor

    $89.00
    Catalog No. M60184
    A novel potent, selective and cell permeable homologous protein lysine methyltransferases G9a and GLP inhibitor.
  298. UNC1215, L3MBTL3 Domain Inhibitor

    $119.00
    Catalog No. M60084
    A highly potent and selective small molecule inhibitor for the methyl-lysine (Kme) reading function of L3MBTL3.
  299. UNC2170, Methyl-lysine Binding Protein 53BP1 Inhibitor

    $99.00
    Catalog No. M60260
    A selective and cell permeable methyl-lysine binding protein 53BP1 antagonist.
  300. UNC2327, Allosteric PRMT3 Inhibitor

    $129.00
    Catalog No. M60253
    A potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor.
  301. UNC669, L3MBTL1 Domain Inhibitor

    $89.00
    Catalog No. M60083
    A potent and selective small molecule inhibitor for the methyl-lysine (Kme) reading function of L3MBTL1
  302. Verteporfin (Visudyne), YAP Inhibitor

    $59.00
    Catalog No. M60247
    A potent and selective YAP inhibitor to disrupt YAP-TEAD interactions and enhance trypsin cleavage of YAP.
  303. VLX600, Mitochondrial OXPHOS Inhibitor

    $69.00
    Catalog No. M60261
    A potent and selective mitochondrial OXPHOS inhibitor.
  304. VR23, Proteasome Inhibitor

    $99.00
    Catalog No. M60307
    A potent and selective proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 μM for trypsin-like proteasomes, chymotrypsin-like proteasomes,
  305. WAY-316606, Secreted Frizzled-related Protein-1 (sFRP-1) Inhibitor

    $139.00
    Catalog No. M60215
    A novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) to increase Wnt signaling.
  306. WDR5-0103, WDR5 Inhibitor

    $89.00
    Catalog No. M60233
    A potent and selective WD repeat-containing protein 5 (WDR5) antagonist.
  307. WDR5-C47, WDR5-MLL (SET1) Antagonist

    $129.00
    Catalog No. M60118
    A highly potent and selective antagonist of WDR5-MLL interaction.
  308. Wnt-C59, Wnt Antagonist

    $89.00
    Catalog No. M60005
    A potent, selective and oral active Wnt  signaling pathway antagonist.
  309. WP1130 (Degrasyn), Deubiquitinylating Enzyme (DUB) Inhibitor

    $69.00
    Catalog No. M60206
    A cell-permeable, potent and selective inhibitor of the deubiquitinylating enzymes (DUBs).
  310. WS3, β Cell Proliferation Inducer

    $139.00
    Catalog No. M60095
    A highly potent and selective small molecule that promotes pancreatic β cell and RPE cells expansion.
  311. WS6, β Cell Proliferation Inducer

    $139.00
    Catalog No. M60097
    A highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets and shows excellent in vivo efficacy.
  312. WWL113, Ces3 and Ces1f Inhibitor

    $139.00
    Catalog No. M60162
    A novel potent and selective inhibitor of Ces3 and Ces1f
  313. XAV939---Wnt Antagonist

    $89.00
    Catalog No. M60010
    A potent and selective Wnt pathway antagonist; functions to stabilize axin by inhibiting tankyrase 1 and tankyrase 2.
  314. XL888---HSP90 Inhibitor

    $149.00
    Catalog No. M60164
    A highly potent, ATP-competitive and orally bioavailable Hsp90 inhibitor.
  315. Y-27632---Rock Inhibitor

    $69.00
    Catalog No. M60011
    The most widely used Rock kinase inhibitor.
  316. Y-320---IL-17 Immunomodulator

    $89.00
    Catalog No. M60200
    An orally active potent immunomodulator, inhibits IL-15-induced IL-17 production by CD4 T cells.
  317. ZCL278---Cdc42 GTPase Inhibitor

    $119.00
    Catalog No. M60133
    A potent and selective inhibitor of Cdc42 GTPase.
  318. ZLN005---PGC-1α Transcriptional Activator

    $69.00
    Catalog No. M60142
    A potent and selective small molecule PGC-1α transcriptional activator.
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