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1,4-DPCA, Prolyl 4-hydroxylase (P4H) Inhibitor

1,4-DPCA, Prolyl 4-hydroxylase (P4H) Inhibitor

$29.00
A selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor.
Catalog No. Unit Price Qty
M60288-2s 2 mg solid $29.00

Details

Product Information
Molecular Weight: 240.21
Formula: C13H8N2O3
Purity: ≥98%
CAS#: 331830-20-7
Solubility: DMSO up to 10 mM, EtOH up to 20 mM
Chemical Name: 4-oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

1,4-DPCA is a selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits α-prolyl 4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1α for destruction upon hydroxylation of a specific proline residue. It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis.

How to Use:

In vitro: 1,4-DPCA was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a

Reference:

  • 1. Jaakkola P, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) Science. 292(5516):468-72. 
  • 2. Franklin TJ, et al. Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. (2001) Biochem J. 353(Pt 2):333-8.
  • 3. Banerji B, et al. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. (2005) Chem Commun (Camb). (43):5438-40. 

1_4DPCA_spec.pdf      
1_4DPCA_MSDS.pdf      



Products are for research use only. Not for human use. 

Description

Details

Product Information
Molecular Weight: 240.21
Formula: C13H8N2O3
Purity: ≥98%
CAS#: 331830-20-7
Solubility: DMSO up to 10 mM, EtOH up to 20 mM
Chemical Name: 4-oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

1,4-DPCA is a selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits α-prolyl 4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1α for destruction upon hydroxylation of a specific proline residue. It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis.

How to Use:

In vitro: 1,4-DPCA was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a

Reference:

  • 1. Jaakkola P, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) Science. 292(5516):468-72. 
  • 2. Franklin TJ, et al. Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. (2001) Biochem J. 353(Pt 2):333-8.
  • 3. Banerji B, et al. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. (2005) Chem Commun (Camb). (43):5438-40. 

1_4DPCA_spec.pdf      
1_4DPCA_MSDS.pdf      



Products are for research use only. Not for human use. 

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