Language:English
Language:

Xcessbio

Place your promotion here

You have no items in your shopping cart.

A-366, G9a/GLP HMTase Inhibitor

A-366, G9a/GLP HMTase Inhibitor

$139.00
A novel highly potent, selective and cell permeable G9a/GLP histone lysine methyltransferase inhibitor.
Catalog No. Unit Price Qty
M60210-2s 2 mg solid $139.00

Details

Product Information
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.
Purity: ≥98%
CAS#: 1527503-11-2
Solubility: DMSO up to 100 mM
Chemical Name: 5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine
Molecular Weight: 329.44
Formula: C19H27N3O2


Biological Activity:

 

A-366 is a novel highly potent, selective and cell permeable G9a/GLP histone lysine methyltransferase inhibitor with an IC50~3.3 nM. It has selectivity > 1000-fold over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC50 of 100 nM and exhibits minimal cellular toxicity compared with previous quinazoline-based probes, such as BIX-01294 and UNC0638.

 

How to Use:

 

In vitro:  A-366 was used at 1 µM in vitro and cellular assays.

 

In vivo: n/a

 

Reference:

 

  1. 1. Sweis RF, et al. Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. (2014) ACS Med Chem Lett. 5(2):205-9.
  2. 2. http://www.thesgc.org/chemical-probes/A-366






Products are for research use only. Not for human use.

Description

Details

Product Information
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.
Purity: ≥98%
CAS#: 1527503-11-2
Solubility: DMSO up to 100 mM
Chemical Name: 5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine
Molecular Weight: 329.44
Formula: C19H27N3O2


Biological Activity:

 

A-366 is a novel highly potent, selective and cell permeable G9a/GLP histone lysine methyltransferase inhibitor with an IC50~3.3 nM. It has selectivity > 1000-fold over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC50 of 100 nM and exhibits minimal cellular toxicity compared with previous quinazoline-based probes, such as BIX-01294 and UNC0638.

 

How to Use:

 

In vitro:  A-366 was used at 1 µM in vitro and cellular assays.

 

In vivo: n/a

 

Reference:

 

  1. 1. Sweis RF, et al. Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. (2014) ACS Med Chem Lett. 5(2):205-9.
  2. 2. http://www.thesgc.org/chemical-probes/A-366






Products are for research use only. Not for human use.

Reviews

Write Your Review

How do you rate this product? *

Price:
Value:
Quality: