Language:English
Language:

Xcessbio

Place your promotion here

You have no items in your shopping cart.

AA92593, Antagonist of Melanopsin-mediated Photo-transduction

AA92593, Antagonist of Melanopsin-mediated Photo-transduction

$139.00
A potent and selective small molecule antagonist of melanopsin-mediated photo-transduction.
Catalog No. Unit Price Qty
M60143-5s 5 mg solid $139.00

Details

Product Information
Molecular Weight: 269.36
Formula: C13H19NO3S
Purity: ≥98%
CAS#: 457961-34-1
Solubility: DMSO up to 100 mM
Chemical Name: 1-((4-methoxy-3-methylphenyl)sulfonyl)piperidine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

 

AA92593 is a potent and selective small molecule antagonist of melanopsin-mediated photo-transduction (IC50 ~160 nM). It inhibits melanopsin (opsinamides) by competing with retinal binding to melanopsin, and inhibits its function without affecting rod- and cone-mediated responses. In vivo administration of AA92593 to mice specifically and reversibly modified melanopsin-dependent light responses, including the pupillary light reflex and light aversion. Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image-forming photic responses. The discovery of AA92593 raises the prospect of therapeutic control of the melanopsin photo-transduction system to regulate light-dependent behavior and remediate pathological conditions.

 

How to Use:

 

In vitro:  AA92593 was used at 10 µM final concentration in various in vitro assays.

In vivo: AA92593 was dosed intraperitoneally 30 mg/kg 20 min before PLR measurement attenuated pupil constriction in response to light (1013 ph cm-2 s-1) by ~50% in adult rd mice. 

 

Reference:

  •  1. Jones KA, et al. Small-molecule antagonists of melanopsin-mediated phototransduction. (2013) Nat Chem Biol. 9(10):630-5. 







Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 269.36
Formula: C13H19NO3S
Purity: ≥98%
CAS#: 457961-34-1
Solubility: DMSO up to 100 mM
Chemical Name: 1-((4-methoxy-3-methylphenyl)sulfonyl)piperidine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

 

AA92593 is a potent and selective small molecule antagonist of melanopsin-mediated photo-transduction (IC50 ~160 nM). It inhibits melanopsin (opsinamides) by competing with retinal binding to melanopsin, and inhibits its function without affecting rod- and cone-mediated responses. In vivo administration of AA92593 to mice specifically and reversibly modified melanopsin-dependent light responses, including the pupillary light reflex and light aversion. Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image-forming photic responses. The discovery of AA92593 raises the prospect of therapeutic control of the melanopsin photo-transduction system to regulate light-dependent behavior and remediate pathological conditions.

 

How to Use:

 

In vitro:  AA92593 was used at 10 µM final concentration in various in vitro assays.

In vivo: AA92593 was dosed intraperitoneally 30 mg/kg 20 min before PLR measurement attenuated pupil constriction in response to light (1013 ph cm-2 s-1) by ~50% in adult rd mice. 

 

Reference:

  •  1. Jones KA, et al. Small-molecule antagonists of melanopsin-mediated phototransduction. (2013) Nat Chem Biol. 9(10):630-5. 







Products are for research use only. Not for human use.

Reviews

Write Your Review

How do you rate this product? *

Price:
Value:
Quality: