AMI-1, Histone Methyltransferase Inhibitor


Catalog No. size PriceQuantity
M60272-2S 2 mg solid $79
M60272-10S 10 mg solid $316

Description

AMI-1 is a potent and selective arginine methyltransferase inhibitor, is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements.

Product information

CAS Number: 20324-87-2

Molecular Weight: 548.45

Formula: C21H14N2Na2O9S2

Chemical Name: sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate)

Smiles: [Na+].[Na+].[O-]S(=O)(=O)C1C=C(O)C2=CC=C(C=C2C=1)NC(=O)NC1=CC2=CC(=CC(O)=C2C=C1)S([O-])(=O)=O

InChiKey: MOUNHKKCIGVIDI-UHFFFAOYSA-L

InChi: InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM, Water up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

AMI-1 was used at 10-30 µM final concentration in vitro and in cellular assays.

In Vivo:

AMI-1 was dosed by intranasal injection to Chronic AIPI rats at 50 μL (concentration of 0.1 mg/mL).

References:

  1. Cheng D, et al. Small molecule regulators of protein arginine methyltransferases. (2004) J Biol Chem. 279(23):23892-9.
  2. Sun Q, et al. PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation. (2015) J Immunol. 195(1):298-306.

Products are for research use only. Not for human use.


Documents

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed