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BAY11-7082, E2 Ubiquitin Conjugating Enzyme Inhibitor

BAY11-7082, E2 Ubiquitin Conjugating Enzyme Inhibitor

$89.00
A potent and selective E2 ubiquitin (Ub) conjugating enzyme inhibitor.
Catalog No. Unit Price Qty
M60309-2s 2 mg solid $89.00

Details

Product Information
Molecular Weight: 207.25
Formula: C10H9NO2 S
Purity: ≥98%
CAS#: 19542-67-7
Solubility: DMSO up to 100 mM
Chemical Name: (E)-3-tosylacrylonitrile
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

BAY11-7082 is a potent and selective E2 ubiquitin (Ub) conjugating enzyme inhibitor. It inhibits the conjugation of Ub to a range of E2 enzymes and inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. BAY11-7082 also reversibly activates MAPK signaling and induces apoptosis of leukemic T cell and B-cell lymphoma cell lines.

How to Use:


In vitro:
BAY11-7082 was used at 10-20 µM final concentration in various assays.
In vivo:
n/a

Reference:

  • 1. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. (1997) J Biol Chem. 272(34):21096-103.
  • 2. Mori N, et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. (2002) Blood. 100(5):1828-34.
  • 3. Strickson S, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. (2013) Biochem J. 451(3):427-37. 


BAY11-7082_spec.pdf      
BAY11-7082_MSDS.pdf      


Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 207.25
Formula: C10H9NO2 S
Purity: ≥98%
CAS#: 19542-67-7
Solubility: DMSO up to 100 mM
Chemical Name: (E)-3-tosylacrylonitrile
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

BAY11-7082 is a potent and selective E2 ubiquitin (Ub) conjugating enzyme inhibitor. It inhibits the conjugation of Ub to a range of E2 enzymes and inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. BAY11-7082 also reversibly activates MAPK signaling and induces apoptosis of leukemic T cell and B-cell lymphoma cell lines.

How to Use:


In vitro:
BAY11-7082 was used at 10-20 µM final concentration in various assays.
In vivo:
n/a

Reference:

  • 1. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. (1997) J Biol Chem. 272(34):21096-103.
  • 2. Mori N, et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. (2002) Blood. 100(5):1828-34.
  • 3. Strickson S, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. (2013) Biochem J. 451(3):427-37. 


BAY11-7082_spec.pdf      
BAY11-7082_MSDS.pdf      


Products are for research use only. Not for human use.

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