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BRD9757, HDAC6 Inhibitor

BRD9757, HDAC6 Inhibitor

$129.00
A highly potent and selective HDAC6 inhibitor.
Catalog No. Unit Price Qty
M60117-2 10 mM DMSO (1.573 mL) $129.00
M60117-2s 2 mg solid $129.00

Details

Product Information
Molecular Weight: 127.14
Formula: C6H9NO2
Purity: ≥98%
CAS#: 1423058-85-8
Solubility: DMSO up to 100 mM
Chemical Name: N-hydroxycyclopent-1-enecarboxamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. It has >20-fold selectivity for class I and > 400-fold selectivity for class II HDACs tested. BRD9757 is absence of a surface-binding motif. It demonstrates that high selectivity and potent inhibition of HDAC6 can be achieved through careful choice of linker element only. BRD9757 can be used as a useful tool for probing the biological functions and relevance of the different HDAC isoforms, and serves as a basis for new selective inhibitors of other HDAC isoforms.


How to Use:

In vitro:  BRD9757 was suggested to be used at 10 µM final concentration in vitro and in cellular assays.

In vivo:  n/a


Reference:

  1. 1. Wagner FF, et al. Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif. (2013) J Med Chem. 56 (4), 1772–1776.


BRD9757_spec.pdf

BRD9757_MSDS.pdf



Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 127.14
Formula: C6H9NO2
Purity: ≥98%
CAS#: 1423058-85-8
Solubility: DMSO up to 100 mM
Chemical Name: N-hydroxycyclopent-1-enecarboxamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. It has >20-fold selectivity for class I and > 400-fold selectivity for class II HDACs tested. BRD9757 is absence of a surface-binding motif. It demonstrates that high selectivity and potent inhibition of HDAC6 can be achieved through careful choice of linker element only. BRD9757 can be used as a useful tool for probing the biological functions and relevance of the different HDAC isoforms, and serves as a basis for new selective inhibitors of other HDAC isoforms.


How to Use:

In vitro:  BRD9757 was suggested to be used at 10 µM final concentration in vitro and in cellular assays.

In vivo:  n/a


Reference:

  1. 1. Wagner FF, et al. Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif. (2013) J Med Chem. 56 (4), 1772–1776.


BRD9757_spec.pdf

BRD9757_MSDS.pdf



Products are for research use only. Not for human use.

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