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DMOG, Prolyl 4-hydroxylase (P4H) Inhibitor

DMOG, Prolyl 4-hydroxylase (P4H) Inhibitor

$39.00
A selective, competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor.
Catalog No. Unit Price Qty
M60287-2s 2 mg solid $39.00

Details

Product Information
Molecular Weight: 175.14
Formula: C6H9NO5
Purity: ≥98%
CAS#: 89464-63-1
Solubility: DMSO up to 100 mM; Water up to 100 mM
Chemical Name: methyl 2-((2-methoxy-2-oxoethyl)amino)-2-oxoacetate
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

DMOG is a selective, competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG acts as a pro-angiogenic compound, acting via the HIF-1α system.

How to Use:


In vitro: DMOG was used at 100 µM final concentration in vitro and in cellular assays.
In vivo: n/a


Reference:

  • 1. Jaakkola P, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) Science. 292(5516):468-72. 
  • 2. Lomb DJ, et al. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons. (2009) Mol Pharmacol. 75(5):1198-209. 
  • 3. Ayrapetov MK, et al. Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. (2011) PLoS One. 6(10):e26064. 
  • 4. Barnucz E, et al. Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. (2013) J Pharmacol Exp Ther. 345(1):25-31.


DMOG_spec.pdf      

DMOG_MSDS.pdf      


Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 175.14
Formula: C6H9NO5
Purity: ≥98%
CAS#: 89464-63-1
Solubility: DMSO up to 100 mM; Water up to 100 mM
Chemical Name: methyl 2-((2-methoxy-2-oxoethyl)amino)-2-oxoacetate
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

DMOG is a selective, competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG acts as a pro-angiogenic compound, acting via the HIF-1α system.

How to Use:


In vitro: DMOG was used at 100 µM final concentration in vitro and in cellular assays.
In vivo: n/a


Reference:

  • 1. Jaakkola P, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) Science. 292(5516):468-72. 
  • 2. Lomb DJ, et al. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons. (2009) Mol Pharmacol. 75(5):1198-209. 
  • 3. Ayrapetov MK, et al. Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. (2011) PLoS One. 6(10):e26064. 
  • 4. Barnucz E, et al. Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. (2013) J Pharmacol Exp Ther. 345(1):25-31.


DMOG_spec.pdf      

DMOG_MSDS.pdf      


Products are for research use only. Not for human use.

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