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Fatostatin A, Sterol Regulatory Binding Proteins (SREBPs) Inhibitor

Fatostatin A, Sterol Regulatory Binding Proteins (SREBPs) Inhibitor

$59.00
Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs).
Catalog No. Unit Price Qty
M60180-2s 2mg solid $59.00

Details

Product Information
Molecular Weight: 294.41
Formula: C18H18N2S
Purity: ≥98%
CAS#: 298197-04-3
Solubility: DMSO up to 50 mM
Chemical Name: 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs). It inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). It blocks adipogenesis by inhibiting the activation of SREBP-1 and SREBP-2. It exhibits anti-proliferative effects on DU 145 cells independently of IGF-1 signaling (IC50~0.1 μM). Fatostatin A can prevent increases in body weight, blood glucose and hepatic fat accumulation and reverses hyperglycemia in diabetic (ob/ob) mice, even under uncontrolled food intake. Fatostatin A may serve as a tool for gaining further insights into the regulation of SREBP.

 

How to Use:

  • In vitro:  Fatostatin A was used at 10-20 µM in vitro.
  • In vivo:  Fatostatin A was delivered intraperitoneally at 30 mg/kg once daily for 28 days in ob/ob mice model.

 

Reference: 

  • 1. Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. (2003) J Biol Chem. 278(9):7320-4.
  • 2. Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. (2009) Chem Biol. 16(8):882-92. 

 

Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 294.41
Formula: C18H18N2S
Purity: ≥98%
CAS#: 298197-04-3
Solubility: DMSO up to 50 mM
Chemical Name: 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs). It inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). It blocks adipogenesis by inhibiting the activation of SREBP-1 and SREBP-2. It exhibits anti-proliferative effects on DU 145 cells independently of IGF-1 signaling (IC50~0.1 μM). Fatostatin A can prevent increases in body weight, blood glucose and hepatic fat accumulation and reverses hyperglycemia in diabetic (ob/ob) mice, even under uncontrolled food intake. Fatostatin A may serve as a tool for gaining further insights into the regulation of SREBP.

 

How to Use:

  • In vitro:  Fatostatin A was used at 10-20 µM in vitro.
  • In vivo:  Fatostatin A was delivered intraperitoneally at 30 mg/kg once daily for 28 days in ob/ob mice model.

 

Reference: 

  • 1. Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. (2003) J Biol Chem. 278(9):7320-4.
  • 2. Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. (2009) Chem Biol. 16(8):882-92. 

 

Products are for research use only. Not for human use.

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