Language:English
Language:

Xcessbio

Place your promotion here

You have no items in your shopping cart.

HBX41108, USP7 Inhibitor

HBX41108, USP7 Inhibitor

$129.00
A potent and selective ubiquitin-specific protease 7 (USP7) inhibitor.
Catalog No. Unit Price Qty
M60244-2s 2 mg solid $129.00

Details

Product Information
Molecular Weight: 266.64
Formula: C13H3ClN4O
Purity: ≥98%
CAS#: 924296-39-9
Solubility: DMSO up to 100 mM
Chemical Name: (3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

HBX41108 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM. Kinetics data indicate it is an uncompetitive reversible inhibition mechanism. It inhibits USP7-mediated p53 deubiquitination (IC50 ~0.8 μM). It can also stabilize p53 and activate the transcription of a p53 target gene without inducing genotoxic stress. HBX41108 inhibits cancer cell growth, and induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

How to Use:


In vitro:
HBX41108 was used at 10 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. (2009) Mol Cancer Ther. 8(8):2286-95.
  • 2. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. (2010) ChemMedChem. 5(4):552-8. 


HBX41108_spec.pdf     
HBX41108_MSDS.pdf 

Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 266.64
Formula: C13H3ClN4O
Purity: ≥98%
CAS#: 924296-39-9
Solubility: DMSO up to 100 mM
Chemical Name: (3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

HBX41108 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM. Kinetics data indicate it is an uncompetitive reversible inhibition mechanism. It inhibits USP7-mediated p53 deubiquitination (IC50 ~0.8 μM). It can also stabilize p53 and activate the transcription of a p53 target gene without inducing genotoxic stress. HBX41108 inhibits cancer cell growth, and induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

How to Use:


In vitro:
HBX41108 was used at 10 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. (2009) Mol Cancer Ther. 8(8):2286-95.
  • 2. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. (2010) ChemMedChem. 5(4):552-8. 


HBX41108_spec.pdf     
HBX41108_MSDS.pdf 

Products are for research use only. Not for human use.

Reviews

Write Your Review

How do you rate this product? *

Price:
Value:
Quality: