Language:English
Language:

Xcessbio

Place your promotion here

You have no items in your shopping cart.

IOX2, HIF Prolyl-Hydroxylases (PHD2) Inhibitor

IOX2, HIF Prolyl-Hydroxylases (PHD2) Inhibitor

$89.00
A potent and selective PHD (HIF prolyl-hydroxylases) inhibitor with cellular activity.
Catalog No. Unit Price Qty
M66054-2s 2mg solid $89.00
M66054-2 10 mM in DMSO (0.568 mL) $89.00
M66054-50s 50mg solid $880.00

Details

Product Information
Molecular Weight: 352.34
Formula: C19H16N2O5
Purity: ≥98%
CAS#: 931398-72-0
Solubility: DMSO up to 100 mM
Chemical Name: 2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

IOX2 is a potent, selective and cell permeable inhibitor of hypoxia inducible factor 1α (HIF1α) prolyl hydroxylase-2 (PHD2). It inhibits PHD2 with an IC50 ~21 nM, and exhibits over 100-fold selectivity against JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM.

 

How to Use:

  •  In vitro:  IOX2 was usually used at 10-50µM final concentration in vitro
  •  In vivo: n/a

 

Reference:

  1. 1. Murray JK, et al. Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. (2010) J Comb Chem. 12(5):676-86.
  1. 2. SGC website: http://www.thesgc.org/scientists/chemical_probes/IOX2
  1. 3. Tian YM, et al. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. (2011) J Biol Chem. 286(15):13041-51.




Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 352.34
Formula: C19H16N2O5
Purity: ≥98%
CAS#: 931398-72-0
Solubility: DMSO up to 100 mM
Chemical Name: 2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

IOX2 is a potent, selective and cell permeable inhibitor of hypoxia inducible factor 1α (HIF1α) prolyl hydroxylase-2 (PHD2). It inhibits PHD2 with an IC50 ~21 nM, and exhibits over 100-fold selectivity against JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM.

 

How to Use:

  •  In vitro:  IOX2 was usually used at 10-50µM final concentration in vitro
  •  In vivo: n/a

 

Reference:

  1. 1. Murray JK, et al. Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. (2010) J Comb Chem. 12(5):676-86.
  1. 2. SGC website: http://www.thesgc.org/scientists/chemical_probes/IOX2
  1. 3. Tian YM, et al. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. (2011) J Biol Chem. 286(15):13041-51.




Products are for research use only. Not for human use.

Reviews

Write Your Review

How do you rate this product? *

Price:
Value:
Quality: