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KL001, Cryptochrome Activator

KL001, Cryptochrome Activator

$79.00
A novel small molecule specifically interacting with cryptochrome (CRY) and causing lengthening of the circadian period.
Catalog No. Unit Price Qty
M66044-2s 2mg solid $79.00
M66044-2 10 mM in DMSO (0.503 mL) $79.00

Details

Product Information
Molecular Weight: 398.48
Formula: C22H22N2O4S
Purity: ≥98%
CAS#: 309928-48-1
Solubility: DMSO up to 100 mM
Chemical Name: 1-(9H-carbazol-9-yl)-5-(furan-2-yl)-4-(methylsulfonyl)pentan-2-ol
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

KL001 is a novel and specific small molecule activator of cryptochrome (CRY) identified from an unbiased cell-based circadian screen (in human osteosarcoma U2OS cell line harboring a Bmal1-dLuc luciferase reporter). KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In addition, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Therefore, KL001 serves as a useful tool to study the regulation of CRY-dependent physiology and may help development of clock-based therapeutics for treating diabetes.

 

How to Use:

  • In vitro:  KL001 was used at 10-50 µM in vitro and in cellular assays.
  • In vivo: n/a

 

Reference:

  • 1.  Hirota T, et al. Identification of Small Molecule Activators of Cryptochrome. (2012) Science 337(6098):1094-7.



Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 398.48
Formula: C22H22N2O4S
Purity: ≥98%
CAS#: 309928-48-1
Solubility: DMSO up to 100 mM
Chemical Name: 1-(9H-carbazol-9-yl)-5-(furan-2-yl)-4-(methylsulfonyl)pentan-2-ol
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

KL001 is a novel and specific small molecule activator of cryptochrome (CRY) identified from an unbiased cell-based circadian screen (in human osteosarcoma U2OS cell line harboring a Bmal1-dLuc luciferase reporter). KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In addition, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Therefore, KL001 serves as a useful tool to study the regulation of CRY-dependent physiology and may help development of clock-based therapeutics for treating diabetes.

 

How to Use:

  • In vitro:  KL001 was used at 10-50 µM in vitro and in cellular assays.
  • In vivo: n/a

 

Reference:

  • 1.  Hirota T, et al. Identification of Small Molecule Activators of Cryptochrome. (2012) Science 337(6098):1094-7.



Products are for research use only. Not for human use.

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