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NU9056--- KAT5 (Tip60) Histone Acetyltransferase Inhibitor

NU9056--- KAT5 (Tip60) Histone Acetyltransferase Inhibitor

$69.00
A potent and selective KAT5 (Tip60) histone acetyltransferase inhibitor.
Catalog No. Unit Price Qty
M60147-2 10 mM in DMSO (0.861 mL) $69.00

Details

Product Information
Molecular Weight: 232.37
Formula: C6H4N2S4
Purity: ≥98%
CAS#: n/a
Solubility: DMSO up to 100 mM
Chemical Name: 1,2-di(isothiazol-5-yl)disulfane
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

NU9056 is a potent and selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 are < 2 µM, 60 µM, 36 µM, and >100 μM for KAT5, p300, pCAF and GCN5, respectively), identified by a high-throughput screening. NU9056 inhibited cellular proliferation in a panel of prostate cancer cell lines (50% growth inhibition, 8-27 µM) and induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. The protein levels of androgen receptor, prostate specific antigen, p53 and p21 were decreased in response to treatment with NU9056. Furthermore, pre-treatment with NU9056 inhibited both ATM phosphorylation and Tip60 stabilization in response to ionizing radiation. NU9056 is a very useful chemical probe to study Tip60 (KAT5) histone acetyltransferase function. 

 

How to Use:

  • In vitro:  NU9056 was used at 24 µM final concentration in vitro and in cellular assays.
  • In vivo:  n/a

 

Reference:

  1. 1. Coffey K, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. (2012) PLoS One. 7(10):e45539. 

 

 

Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 232.37
Formula: C6H4N2S4
Purity: ≥98%
CAS#: n/a
Solubility: DMSO up to 100 mM
Chemical Name: 1,2-di(isothiazol-5-yl)disulfane
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

NU9056 is a potent and selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 are < 2 µM, 60 µM, 36 µM, and >100 μM for KAT5, p300, pCAF and GCN5, respectively), identified by a high-throughput screening. NU9056 inhibited cellular proliferation in a panel of prostate cancer cell lines (50% growth inhibition, 8-27 µM) and induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. The protein levels of androgen receptor, prostate specific antigen, p53 and p21 were decreased in response to treatment with NU9056. Furthermore, pre-treatment with NU9056 inhibited both ATM phosphorylation and Tip60 stabilization in response to ionizing radiation. NU9056 is a very useful chemical probe to study Tip60 (KAT5) histone acetyltransferase function. 

 

How to Use:

  • In vitro:  NU9056 was used at 24 µM final concentration in vitro and in cellular assays.
  • In vivo:  n/a

 

Reference:

  1. 1. Coffey K, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. (2012) PLoS One. 7(10):e45539. 

 

 

Products are for research use only. Not for human use.

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