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OG-L002, LSD1 Inhibitor

OG-L002, LSD1 Inhibitor

$89.00
A highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1).
Catalog No. Unit Price Qty
M60161-2s 2 mg solid $89.00
M60161-2 10 mM in DMSO (0.888 mL) $89.00

Details

Product Information
Molecular Weight: 225.29
Formula: C15H15NO
Purity: ≥98%
CAS#: 1357302-64-7
Solubility: DMSO up to 100 mM
Chemical Name: 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

OG-L002 is a highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~20 nM, and has moderate inhibitory activity against monoamine oxidases MAO-A and MAO-B with IC50 ~1.38 µM and 0.72µM respectively. It potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. OG-L002 suppressed primary lytic infection of HSV in vivo in a mouse model.


How to Use:

  • In vitro: OG-L002 was used at 1 µM in vitro.
  • In vivo: OG-L002 was administered by intraperitoneal injection once a day at a dose of 20-40 mg/kg to the primary infection mouse model.


Reference:

  1. 1. Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. (2013) MBio. 4(1):e00558-12.



Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 225.29
Formula: C15H15NO
Purity: ≥98%
CAS#: 1357302-64-7
Solubility: DMSO up to 100 mM
Chemical Name: 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

OG-L002 is a highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~20 nM, and has moderate inhibitory activity against monoamine oxidases MAO-A and MAO-B with IC50 ~1.38 µM and 0.72µM respectively. It potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. OG-L002 suppressed primary lytic infection of HSV in vivo in a mouse model.


How to Use:

  • In vitro: OG-L002 was used at 1 µM in vitro.
  • In vivo: OG-L002 was administered by intraperitoneal injection once a day at a dose of 20-40 mg/kg to the primary infection mouse model.


Reference:

  1. 1. Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. (2013) MBio. 4(1):e00558-12.



Products are for research use only. Not for human use.

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