OG-L002 --- LSD1 Inhibitor

OG-L002 is a highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~20 nM, and has moderate inhibitory activity against monoamine oxidases MAO-A and MAO-B with IC50 ~1.38 µM and 0.72µM respectively. It potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. OG-L002 suppressed primary lytic infection of HSV in vivo in a mouse model.

Product information

CAS Number: 1357302-64-7

Molecular Weight: 225.29

Formula: C15H15NO

Chemical Name: 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol

Smiles: N[C@@H]1C[C@H]1C1C=CC(=CC=1)C1=CC(O)=CC=C1

InChiKey: DSOJSZXQRJGBCW-LSDHHAIUSA-N

InChi: InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m0/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

OG-L002 was used at 1 µM in vitro.

In Vivo:

OG-L002 was administered by intraperitoneal injection once a day at a dose of 20-40 mg/kg to the primary infection mouse model.

References:

1. Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. (2013) MBio. 4(1):e00558-12.

Products are for research use only. Not for human use.

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