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PR-619, Deubiquitinylating Enzyme (DUB) Inhibitor

PR-619, Deubiquitinylating Enzyme (DUB) Inhibitor

$59.00
PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs).
Catalog No. Unit Price Qty
M60199-2s 2 mg solid $59.00

Details

Product Information
Molecular Weight: 223.28
Formula: C7H5N5S2
Purity: ≥98%
CAS#: 2645-32-1
Solubility: DMSO up to 100 mM
Chemical Name: 3,5-dithiocyanatopyridine-2,6-diamine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs) with IC50 of 1-20 μM. PR-619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h) without direct impairment of proteasomal proteolysis. PR-619 treatment results in upregulation of both K48 - and K63-linked polyUb chains. It induces HCT116 cell death with EC50 ~6.3 μM.


How to Use:

  • In vitro: PR-619 was used at 10-50 µM final concentration in various in vitro assays.
  • In vivo: n/a


Reference:

  1. 1. Altun M, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (2011) Chem Biol. 18(11):1401-12.



Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 223.28
Formula: C7H5N5S2
Purity: ≥98%
CAS#: 2645-32-1
Solubility: DMSO up to 100 mM
Chemical Name: 3,5-dithiocyanatopyridine-2,6-diamine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs) with IC50 of 1-20 μM. PR-619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h) without direct impairment of proteasomal proteolysis. PR-619 treatment results in upregulation of both K48 - and K63-linked polyUb chains. It induces HCT116 cell death with EC50 ~6.3 μM.


How to Use:

  • In vitro: PR-619 was used at 10-50 µM final concentration in various in vitro assays.
  • In vivo: n/a


Reference:

  1. 1. Altun M, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (2011) Chem Biol. 18(11):1401-12.



Products are for research use only. Not for human use.

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