Language:English
Language:

Xcessbio

Place your promotion here

You have no items in your shopping cart.

Remodelin, Acetyl-transferase NAT10 Inhibitor

Remodelin, Acetyl-transferase NAT10 Inhibitor

$139.00
Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
Catalog No. Unit Price Qty
M60187-2s 2 mg solid $139.00
M60187-2 10 mM in DMSO (0.685 mL) $139.00

Details

Product Information
Molecular Weight: 282.36
Formula: C15H14N4S
Purity: ≥98%
CAS#:  949912-58-7
Solubility: DMSO up to 100 mM
Chemical Name: 4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. It can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.


How to Use:

  • In vitro: Remodelin was used at 1-10 µM in vitro and cellular assays.
  • In vivo: n/a

Reference:

  1. 1. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. (2014) Science 344(6183):527-32.




Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 282.36
Formula: C15H14N4S
Purity: ≥98%
CAS#:  949912-58-7
Solubility: DMSO up to 100 mM
Chemical Name: 4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. It can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.


How to Use:

  • In vitro: Remodelin was used at 1-10 µM in vitro and cellular assays.
  • In vivo: n/a

Reference:

  1. 1. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. (2014) Science 344(6183):527-32.




Products are for research use only. Not for human use.

Reviews

Write Your Review

How do you rate this product? *

Price:
Value:
Quality: