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TCID, Ubiquitin C-terminal Hydrolase-L3 (UCH-L3) Inhibitor

TCID, Ubiquitin C-terminal Hydrolase-L3 (UCH-L3) Inhibitor

$99.00
A novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L3 (UCH-L3)
Catalog No. Unit Price Qty
M60197-2s 2 mg solid $99.00

Details

Product Information
Molecular Weight: 283.92
Formula: C9H2Cl4O2
Purity: ≥98%
CAS#: 30675-13-9
Solubility: DMSO up to 50 mM
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

TCID is a novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L3 (UCH-L3) with an IC50 ~0.6 μM. It has ~125-fold greater selectivity over UCH-L1 (ubiquitin C-terminal hydrolase L1, IC50 ~75 μM). TCID can diminish glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.


How to Use:

  • In vitro: TCID was used at 10-30 µM final concentration in various in vitro assays.
  • In vivo: n/a


Reference:

  1. 1. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. (2003) Chem Biol. 10(9):837-46.
  2. 2. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. (2013) PLoS One. 8(3):e58863.


Products are for research use only. Not for human use.

Description

Details

Product Information
Molecular Weight: 283.92
Formula: C9H2Cl4O2
Purity: ≥98%
CAS#: 30675-13-9
Solubility: DMSO up to 50 mM
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

TCID is a novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L3 (UCH-L3) with an IC50 ~0.6 μM. It has ~125-fold greater selectivity over UCH-L1 (ubiquitin C-terminal hydrolase L1, IC50 ~75 μM). TCID can diminish glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.


How to Use:

  • In vitro: TCID was used at 10-30 µM final concentration in various in vitro assays.
  • In vivo: n/a


Reference:

  1. 1. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. (2003) Chem Biol. 10(9):837-46.
  2. 2. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. (2013) PLoS One. 8(3):e58863.


Products are for research use only. Not for human use.

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