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Stem cell

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  1. HLY78, Wnt Activator

    Catalog No. M60140
    An activator of the Wnt pathway by targeting the DIX domain of Axin and potentiating the Axin–LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction.
  2. ID-8, DYRK Inhibitor

    Catalog No. M60102
    A potent and selective small molecule inhibitor of dual-specificity tyrosine phosphorylation- regulated kinase (DYRK).
  3. ISX9, Neurogenic Modulator

    Catalog No. M60274
    A neurogenic modulator.
  4. ITD-1, TGFβ inhibitor

    Catalog No. M60060
    A highly selective TGFβ inhibitor promotes cardiomyogenesis in embryonic stem cells.
  5. IWP-2, Porcupine (Wnt) Inhibitor

    Catalog No. M60115
    A potent and highly selective Wnt signaling antagonist targeting porcupine.
  6. Kartogenin (KGN), Chondrogenesis Modulator

    Catalog No. M60027
    Selectively promote chondrocyte differentiation of human mesenchymal stem cells.
  7. KY02111, Wnt Inhibitor

    Catalog No. M60073
    A potent and selective Wnt inhibitor promotes differentiation of hESCs/iPSCs to cardiomyocytes; might function downstream from GSK3β and APC in b-catenin destruction complex
  8. L755,507, CRISPR Editing Enhancer

    Catalog No. M60237
    CRISPR editing enhancer to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
  9. LDE225, Hedgehog Antagonist

    Catalog No. M60013
    A potent and specific Hedgehog pathway inhibitor (Smo antagonist) in clinical trials.
  10. LDN-193189, BMP inhibitor

    Catalog No. M60008
    A highly potent and selective BMP pathway inhibitor (selective for ALK2 and ALK3); can replace Noggin protein in cellular and in vivo use.
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