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Stem cell

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Items 1 to 61 of 61 total

  1. 5-Azacytidine, DNA Methyltransferase Inhibitor

    Catalog No. M60131
    A classic DNA methyltransferase inhibitor, incorporates into DNA forming covalent adducts with cellular DNMT, depleting enzyme activity.
  2. AA92593, Antagonist of Melanopsin-mediated Photo-transduction

    Catalog No. M60143
    A potent and selective small molecule antagonist of melanopsin-mediated photo-transduction.
  3. ABT-199, BCL-2 inhibitor

    Catalog No. M60075
    A potent BCL-2–selective (BCL-X L) inhibitor with clinical efficacy.
  4. AS8351, KDM5B Inhibitor

    Catalog No. M60330
    A potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B).
  5. Azidothymidine (AZT), Reverse Transcriptase Inhibitor

    Catalog No. M60238
    A selective, orally bioavailable and brain penetrant reverse transcriptase inhibitor.
  6. BIX-01294, G9a/GLP HMTase Inhibitor

    Catalog No. M60216
    A potent and selective G9a and GLP histone lysine methyltransferase inhibitor.
  7. CASIN, Cdc42 Inhibitor

    Catalog No. M60040
    A novel and potent inhibitor of Cdc42; was shown to rescue HSC aging phenotype and promote HSC transplantation efficiency.
  8. CP-690550, JAK Inhibitor

    Catalog No. M60033
    A potent and selective pan-JAK Inhibitor in clinical trials for rheumatoid arthritis.
  9. Cyclosporin A, MPTP Inhibitor and HSC Protector

    Catalog No. M60262
    An inhibitor of the mitochondrial permeability transition pore (MPTP).
  10. Daidzein-2c, Osteogenic Modulator

    Catalog No. M60158
    A potent synthetic daidzein analog with osteogenic induction potentials on human Mesenchymal Stem Cells (MSC).
  11. DAPT, γ-secretase Inhibitor

    Catalog No. M60023
    A γ-secretase inhibitor and widely used as a Notch pathway inhibitor.
  12. DZNep (3-Deazaneplanocin A) --- Histone Methyltransferase Inhibitor

    Catalog No. M60141
    An S-adenosylhomocysteine hydrolase inhibitor, indirectly inhibiting histone methyltransferases and decreasing global DNA methylation
  13. FH1, Hepatocytes Functional Enhancer

    Catalog No. M60127
    FH1 is a potent and selective small molecule that enhances hepatocyte functions and promotes the differentiation and maturation of iPSC-derived hepatocytes toward a more mature phenotype in vitro.
  14. Forskolin, Adenylyl Cyclase Activator

    Catalog No. M60024
    A potent adenylate cyclase activator to increase the intracellular levels of cAMP.
  15. FPH1, Hepatocytes Functional Proliferation Inducer

    Catalog No. M60126
    FPH1 is a potent and selective small molecule that induced Functional Proliferation of primary human Hepatocytes in vitro, identified by a high-throughput, cell-based screening using primary human hepatocytes.
  16. GDC-0449 (Vismodegib), Hedgehog Antagonist

    Catalog No. M60034
    A potent and specific hedgehog pathway inhibitor approved by FDA
  17. GNF4877, β Cell Proliferation Inducer

    Catalog No. M60294
    A highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets.
  18. GNF7156, β Cell Proliferation Inducer

    Catalog No. M60293
    A highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets.
  19. Go6893, PKC Inhibitor

    Catalog No. M60273
    A potent pan-PKC inhibitor.
  20. Hh-Ag1.5, Hedgehog Agonist

    Catalog No. M60004
    The most potent and selective agonist of the Hh pathway (Smoothened/Smo agonist); could replace the recombinant Hh protein to activate the Hh pathway
  21. HLY78, Wnt Activator

    Catalog No. M60140
    An activator of the Wnt pathway by targeting the DIX domain of Axin and potentiating the Axin–LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction.
  22. ID-8, DYRK Inhibitor

    Catalog No. M60102
    A potent and selective small molecule inhibitor of dual-specificity tyrosine phosphorylation- regulated kinase (DYRK).
  23. ISX9, Neurogenic Modulator

    Catalog No. M60274
    A neurogenic modulator.
  24. ITD-1, TGFβ inhibitor

    Catalog No. M60060
    A highly selective TGFβ inhibitor promotes cardiomyogenesis in embryonic stem cells.
  25. IWP-2, Porcupine (Wnt) Inhibitor

    Catalog No. M60115
    A potent and highly selective Wnt signaling antagonist targeting porcupine.
  26. Kartogenin (KGN), Chondrogenesis Modulator

    Catalog No. M60027
    Selectively promote chondrocyte differentiation of human mesenchymal stem cells.
  27. KY02111, Wnt Inhibitor

    Catalog No. M60073
    A potent and selective Wnt inhibitor promotes differentiation of hESCs/iPSCs to cardiomyocytes; might function downstream from GSK3β and APC in b-catenin destruction complex
  28. L755,507, CRISPR Editing Enhancer

    Catalog No. M60237
    CRISPR editing enhancer to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
  29. LDE225, Hedgehog Antagonist

    Catalog No. M60013
    A potent and specific Hedgehog pathway inhibitor (Smo antagonist) in clinical trials.
  30. LDN-193189, BMP inhibitor

    Catalog No. M60008
    A highly potent and selective BMP pathway inhibitor (selective for ALK2 and ALK3); can replace Noggin protein in cellular and in vivo use.
  31. LY411575, γ-secretase Inhibitor

    Catalog No. M60078
    A highly potent, selective, and orally bioavailable inhibitor of gamma secretase.
  32. MC1568, Class IIa HDAC Inhibitor

    Catalog No. M60224
    A potent and selective inhibitor of class IIa histone deacetylases (HDACs), more selective for HD1-A than HD1-B.
  33. ML239, Breast Cancer Stem Cell Inhibitor

    Catalog No. M60282
    A potent and selective breast cancer stem cell inhibitor.
  34. Napabucasin (BBI608), STAT3 Inhibitor

    Catalog No. M60303
    A potent and selective STAT3 inhibitor.
  35. NVP-BGT226, PI3K/mTOR Dual Inhibitor

    Catalog No. M66050
    A PI3K/mTOR dual inhibitor in clinical trials for advanced solid tumors.
  36. NVP-BKM120, PI3K Inhibitor BKM120

    Catalog No. M66051
    A selective PI3K Inhibitor in clinical trials for advanced solid tumors.
  37. NVP-TNKS656, Wnt / Tankyrase Inhibitor

    Catalog No. M60328
    A highly potent, selective and oral bioavailable tankyrase inhibitor for TNKS2.
  38. OAC1, Oct4 Activator

    Catalog No. M60086
    A potent Oct4 activator significantly enhancing iPSC reprogramming efficiency and accelerating the reprogramming process.
  39. P7C3, Neuroprotective Small Molecule

    Catalog No. M60017
    A neuroprotective small molecule with favorable in vivo PK; protects newborn neurons from apoptosis.
  40. PD0325901, MEK Inhibitor

    Catalog No. M60018
    A potent and selective MEK inhibitor.
  41. PluriSIn#1, Pluripotent Cell-specific Inhibitor

    Catalog No. M60085
    A potent small molecule to selectively eliminate human pluripotent stem cells/hPSCs while sparing a large array of tissue-specific stem/progenitor and differentiated cells.
  42. PS48---PDK1 Activator

    Catalog No. M60026
    An allosteric small molecule activator of PDK1.
  43. Purmorphamine, Hedgehog Agonist

    Catalog No. M66055
    A selective hedgehog pathway agonist (Smo agonist).
  44. Pyrintegrin---Cell Survival Enhancer

    Catalog No. M60028
    A potent small molecule promoting hESC survival
  45. Rapamycin, mTOR inhibitor

    Catalog No. M60029
    A potent and selective mTOR inhibitor, directly binding to the mTOR Complex 1 (mTORC1).
  46. RepSox---TGF-β Type I Receptor ALK5 Inhibitor

    Catalog No. M60151
    RepSox (E-616452 or SJN 2511) is a highly potent, selective inhibitor of the TGF-β type I receptor ALK5.
  47. RG108---DNA Methyltransferase Inhibitor

    Catalog No. M60176
    RG108 is a potent, selective and cell permeable inhibitor of DNA methyltransferase.
  48. RO4929097, γ-Secretase Inhibitor

    Catalog No. M60007
    A potent and selective γ-secretase inhibitor; inhibits Notch signaling in stem cells and tumor cells.
  49. SAG, Hedgehog Agonist

    Catalog No. M60081
    A potent, selective, and cell-permeable small-molecule agonist of the Hedgehog pathway.
  50. StemRegenin1 (SR1)---HSC Expansion Molecule

    Catalog No. M60001
    A potent and selective aryl hydrocarbon receptor antagonist; can promote robust expansion of human CD34+ hematopoietic stem and progenitor cells.
  51. SU5402---FGFR inhibitor

    Catalog No. M60025
    A potent and selective inhibitor of FGFR, VEGFR, and PDGFR.
  52. SW033291, 15-PGDH Inhibitor

    Catalog No. M60298
    A highly potent and selective inhibitor of 15-PGDH to increase prostaglandin PGE2 levels in bone marrow and other tissues.
  53. TCID, Ubiquitin C-terminal Hydrolase-L3 (UCH-L3) Inhibitor

    Catalog No. M60197
    A novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L3 (UCH-L3)
  54. Thiazovivin, Rock Inhibitor

    Catalog No. M60009
    A more potent and selective Rock inhibitor; can enhance hESC and hiPSC survival from single cell dissociation.
  55. UM171, Human HSC Self-renewal Agonist

    Catalog No. M60223
    A potent small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice.
  56. UNC0638, G9a HMTase Inhibitor

    Catalog No. M66056
    A potent, selective and cell permeable inhibitor of G9a (EHMT2) and GLP (EHMT1) histone methyltransferases.
  57. Wnt-C59, Wnt Antagonist

    Catalog No. M60005
    A potent, selective and oral active Wnt  signaling pathway antagonist.
  58. WS3, β Cell Proliferation Inducer

    Catalog No. M60095
    A highly potent and selective small molecule that promotes pancreatic β cell and RPE cells expansion.
  59. WS6, β Cell Proliferation Inducer

    Catalog No. M60097
    A highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets and shows excellent in vivo efficacy.
  60. XAV939---Wnt Antagonist

    Catalog No. M60010
    A potent and selective Wnt pathway antagonist; functions to stabilize axin by inhibiting tankyrase 1 and tankyrase 2.
  61. Y-27632---Rock Inhibitor

    Catalog No. M60011
    The most widely used Rock kinase inhibitor.
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