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  1. (S)-crizotinib, MTH1 Inhibitor

    $99.00
    Catalog No. M60208
    A novel potent, selective and cell permeable MTH1 inhibitor.
  2. 4SC-202, HDAC/LSD1 Dual Inhibitor

    $109.00
    Catalog No. M60230
    A potent, selective and orally bioavailable HDAC/LSD1 dual Inhibitor.
  3. A-366, G9a/GLP HMTase Inhibitor

    $139.00
    Catalog No. M60210
    A novel highly potent, selective and cell permeable G9a/GLP histone lysine methyltransferase inhibitor.
  4. A01, Smurf1 E3 Ubiquitin Ligase Inhibitor

    $109.00
    Catalog No. M60249
    A potent and selective Smurf1 E3 ubiquitin ligase inhibitor.
  5. AdipoRon, Adiponectin Receptor/AdipoR agonist

    $129.00
    Catalog No. M60152
    A novel, highly potent, selective and orally active small molecule agonist of adiponectin receptor (AdipoR).
  6. AG-120 (Ivosidenib), IDH1 Inhibitor

    $129.00
    Catalog No. M60318
    A potent, selective and reversible inhibitor of IDH1 in clinical trials.
  7. AG-221 (Enasidenib), IHD2 Inhibitor

    $129.00
    Catalog No. M60296
    A potent and selective inhibitor of IDH2 R140Q mutant.
  8. APY29, IRE1a Modulator

    $109.00
    Catalog No. M60168
    A highly potent and selective small molecule modulator of IRE1α.
  9. AR7, RARα antagonist

    $129.00
    Catalog No. M60116
    A highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RARα.
  10. AS2034178, GPR40 Agonist

    $139.00
    Catalog No. M60221
    A potent, selective and orally bioavailable GPR40 (FFA1) agonist.
  11. Atglistatin, Adipose Triglyceride Lipase (ATGL) Inhibitor

    $119.00
    Catalog No. M60150
    A highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL).
  12. b-AP15 (NSC687852), Deubiquitinases Inhibitor

    $89.00
    Catalog No. M60251
    A potent and selective deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage.
  13. BAM7, BAX Activator

    $109.00
    Catalog No. M60069
    The first potent and selective small molecule activator of BAX, which is a pro-apoptotic BCL-2 family member.
  14. BAY 87-2243, Hypoxia-inducible Factor-1 (HIF-1) Inhibitor

    $119.00
    Catalog No. M60217
    A highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.
  15. BAZ2-ICR, BAZ2 Bromodomain Inhibitor

    $129.00
    Catalog No. M60226
    A potent and selective BAZ2 bromodomain inhibitor.
  16. BG45, HDAC3 Inhibitor

    $59.00
    Catalog No. M60266
    A potent, selective and cell permeable HDAC3 inhibitor.
  17. BI-7273, BRD9 Bromodomain Inhibitor

    $129.00
    Catalog No. M60322
    A potent, selective and cell-permeable BRD9 inhibitor.
  18. BI-9564, BRD9 Bromodomain Inhibitor

    $129.00
    Catalog No. M60323
    A potent, selective and cell-permeable BRD9 inhibitor.
  19. Bioymifi, TRAIL Receptor DR5 Activator

    $109.00
    Catalog No. M60088
    A potent and selective small molecule agonist of DR5.
  20. BQU57, GTPase Ral Inhibitor

    $139.00
    Catalog No. M60228
    A potent and selective GTPase Ral Inhibitor
  21. Bromosporine, Pan-bromodomain Inhibitor

    $129.00
    Catalog No. M60144
    A broad spectrum inhibitor for bromodomains.
  22. CAY10603, HDAC6 Inhibitor

    $129.00
    Catalog No. M60234
    A potent and selective HDAC6 inhibitor.
  23. CB-5083, p97 AAA ATPase Inhibitor

    $129.00
    Catalog No. M60306
    A highly potent, selective and orally bioavailable p97 AAA ATPase inhibitor.
  24. CPI-455, KDM5 Demethylases Inhibitor

    $129.00
    Catalog No. M60326
    A potent and selective KDM5A inhibitor.
  25. CPI203, BET Inhibitor

    $139.00
    Catalog No. M60124
    A novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4, inhibiting Myc expression.
  26. CTEP, mGlu5 Antagonist

    $259.00
    Catalog No. M60099
    A highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor.
  27. Deltarasin, KRAS-PDEδ Inhibitor

    $139.00
    Catalog No. M60218
    A potent and selective small molecular inhibitor of KRAS-PDEδ interaction
  28. EED226, PRC2 Inhibitor

    $139.00
    Catalog No. M60327
    A potent and selective allosteric PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED.
  29. EML425, CBP/p300 Inhibitor

    $129.00
    Catalog No. M60257
    A selective, noncompetitive and cell permeable KAT3 histone acetyltransferases CBP/p300 inhibitor.
  30. EPZ-5676 --- DOT1L inhibitor

    $139.00
    Catalog No. M60123
    A highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S-adenosylmethionine.
  31. EPZ015666 (GSK3235025), PRMT5 Inhibitor

    $129.00
    Catalog No. M60254
    A potent, selective and orally bioavailable Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  32. FASCIN-G2, Fascin Inhibitor

    $129.00
    Catalog No. M60269
    A potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin.
  33. Furamidine, PRMT1 Inhibitor

    $99.00
    Catalog No. M60256
    A potent, selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor.
  34. GNF-7, Ras Signaling Inhibitor

    $129.00
    Catalog No. M60281
    A potent, selective and bioavailable Ras signaling inhibitor.
  35. GNF4877, β Cell Proliferation Inducer

    $159.00
    Catalog No. M60294
    A highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets.
  36. GNF7156, β Cell Proliferation Inducer

    $139.00
    Catalog No. M60293
    A highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets.
  37. GPR39-C3, GPR39 Agonist

    $139.00
    Catalog No. M60209
    The first potent, selective and orally bioavailable GPR39 agonist.
  38. GSK2801, Bromodomain BAZ2A/B Inhibitor

    $129.00
    Catalog No. M60283
    A potent, selective and cell permeable inhibitor of the bromodomain BAZ2A and BAZ2B.
  39. GSK2879552, LSD1 Inhibitor

    $129.00
    Catalog No. M60297
    A highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1).
  40. GSK591 (EPZ015866), PRMT5 Inhibitor

    $109.00
    Catalog No. M60321
    A potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  41. GSK5959, BRPF1 Bromodomain Inhibitor

    $129.00
    Catalog No. M60239
    A potent, selective and cell permeable BRPF1 bromodomain inhibitor.
  42. HCI-2509 (SP2509), Reversible LSD1 Inhibitor.

    $109.00
    Catalog No. M60160
    A highly potent, specific, and reversible Lysine Specific Demethylase-1 (LSD1) inhibitor with in vivo efficacy.
  43. Heclin, HECT E3 Ubiquitin Ligase Inhibitor

    $89.00
    Catalog No. M60248
    A selective HECT E3 ubiquitin ligase inhibitor to inhibit Nedd4, Smurf2 and WWP1.
  44. HLCL-61, PRMT5 Inhibitor

    $109.00
    Catalog No. M60320
    A potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor.
  45. HPOB, HDAC6 Inhibitor

    $79.00
    Catalog No. M60231
    A potent and selective HDAC6 inhibitor.
  46. I-BRD9, Bromodomain Containing Protein 9 (BRD9) Inhibitor

    $129.00
    Catalog No. M60276
    A potent, selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor.
  47. I-CBP112, p300/CBP Bromodomain Inhibitor

    $139.00
    Catalog No. M60128
    A highly potent and selective p300/CBP bromodomain inhibitor.
  48. ID-8, DYRK Inhibitor

    $89.00
    Catalog No. M60102
    A potent and selective small molecule inhibitor of dual-specificity tyrosine phosphorylation- regulated kinase (DYRK).
  49. IDH-C227, IDH1 Inhibitor

    $139.00
    Catalog No. M60043
    A potent and selective inhibitor of the IDH1 R132H mutant with good cellular activity.
  50. INCB024360 (Epacadostat), IDO Inhibitor

    $109.00
    Catalog No. M60292
    A potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor.
  51. IOX4, PHD2 Inhibitor

    $109.00
    Catalog No. M60284
    A potent and selective PHD2 inhibitor.
  52. Ischemin, CBP Bromodomain Inhibitor

    $79.00
    Catalog No. M60229
    A potent, selective and cell permeable CBP bromodomain inhibitor.
  53. KRAS-C9, K-Ras(G12C) Inhibitor

    $139.00
    Catalog No. M60219
    A potent and selective allosteric inhibitor of oncogenic K-Ras(G12C).
  54. KYA1797K, Wnt/β-catenin Inhibitor

    $129.00
    Catalog No. M60317
    A highly potent and selective Wnt/β-catenin inhibitor binding directly to the regulators of G-protein signaling domain of axin.
  55. LLY-507, Protein-lysine Methyltransferase SMYD2 Inhibitor

    $129.00
    Catalog No. M60259
    A potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor.
  56. MS049, PRMT4 and PRMT6 Inhibitor

    $89.00
    Catalog No. M60310
    A potent, selective and cell permeable PRMT4 and PRMT6 inhibitor.
  57. MS436, BRD4 Inhibitor

    $109.00
    Catalog No. M60232
    A potent and selective BET bromodomain inhibitor for BRD4 (1) and BRD4 (2).
  58. MSAB, β-catenin Inhibitor

    $129.00
    Catalog No. M60316
    A potent and selective Wnt/β-catenin inhibitor identified using cell-based chemical screening.
  59. NI-57, BRPF Bromodomain Inhibitor

    $109.00
    Catalog No. M60279
    A potent and selective inhibitor of the bromodomain of the BRPFs.
  60. NVP-TNKS656, Wnt / Tankyrase Inhibitor

    $109.00
    Catalog No. M60328
    A highly potent, selective and oral bioavailable tankyrase inhibitor for TNKS2.
  61. NVS-SM1, SMN2 Splicing Modulator

    $129.00
    Catalog No. M60277
    A highly potent, selective and orally active small molecule SMN2 splicing modulator enhancing SMN exon 7 inclusion.
  62. OAC1, Oct4 Activator

    $109.00
    Catalog No. M60086
    A potent Oct4 activator significantly enhancing iPSC reprogramming efficiency and accelerating the reprogramming process.
  63. OG-L002, LSD1 Inhibitor

    $89.00
    Catalog No. M60161
    A highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1).
  64. OICR9429, WDR5 Antagonist

    $129.00
    Catalog No. M60255
    A potent and selective WD repeat-containing protein 5 (WDR5) antagonist.
  65. ONX-0914, Immunoproteasome Inhibitor

    $139.00
    Catalog No. M60112
    A potent and selective immunoproteasome inhibitor.
  66. Optovin, TRPA1 Activator

    $129.00
    Catalog No. M60103
    A potent and selective small molecule activator of human TRPA1.
  67. ORY-1001 (RG-6016), LSD1 Inhibitor

    $129.00
    Catalog No. M60295
    A highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) in phase I/II.
  68. PBIT, JARID1 Histone Demethylases Inhibitor

    $129.00
    Catalog No. M60170
    PBIT is a potent, specific, reversible and cell-permeable inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases.
  69. PCI-34051, HDAC8 Inhibitor

    $79.00
    Catalog No. M60178
    PCI-34051 is a potent and selective inhibitor of histone deacetylase 8 (HDAC8).
  70. PD-1/PD-L1 Inhibitor C1

    $109.00
    Catalog No. M60312
    A potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions.
  71. PF-04979064, PI3K/mTOR Dual Inhibitor

    $149.00
    Catalog No. M60114
    PF-04979064 is a highly potent and orally bioavailable PI3K/mTOR dual inhibitor developed through structure-based drug design.
  72. PF-CBP1,CBP/p300 Bromodomain Inhibitor

    $129.00
    Catalog No. M60313
    A potent and selective CBP/p300 bromodomain inhibitor.
  73. PFI-3, SMARCA Bromodomains Inhibitor

    $139.00
    Catalog No. M60175
    PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains.
  74. PFI-4, BRPF1 Bromodomain Inhibitor

    $129.00
    Catalog No. M60264
    A potent, selective and cell permeable BRPF1 bromodomain inhibitor.
  75. PRMT1-2e, Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor

    $69.00
    Catalog No. M60181
    PRMT1-2e is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1).
  76. PTC-209, BMI-1 Inhibitor

    $129.00
    Catalog No. M60159
    PTC-209 is a novel potent and selective BMI-1 inhibitor, targeting the BMI-1 self-renewal machinery.
  77. PX-478, Hypoxia-inducible Factor-1α (HIF-1α) Inhibitor

    $129.00
    Catalog No. M60227
    A highly potent and selective Hypoxia-inducible Factor-1α (HIF-1α) inhibitor.
  78. PYZD-4409, Ubiquitin-activating Enzyme (E1) Inhibitor

    $139.00
    Catalog No. M60213
    A novel potent, selective and cell permeable inhibitor of ubiquitin-activating enzyme (E1).
  79. RA190, Ubiquitin Receptor RPN13/ADRM1 Inhibitor

    $139.00
    Catalog No. M60163
    A novel potent and selective inhibitor of proteasome Ubiquitin receptor RPN13/ADRM1.
  80. Remodelin, Acetyl-transferase NAT10 Inhibitor

    $139.00
    Catalog No. M60187
    Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
  81. RGFP966, HDAC3 Inhibitor

    $89.00
    Catalog No. M60156
    RGFP966 is a potent and selective HDAC3 inhibitor.
  82. RN-1, LSD1 Inhibitor

    $109.00
    Catalog No. M60169
    RN-1 is a potent, specific and brain-penetrant Lysine Specific Demethylase-1 (LSD1) inhibitor.
  83. RS-1, CRISPR Editing Enhancer

    $89.00
    Catalog No. M60300
    Previously characterized as a RAD51-Stimulatory compound and now found to be an HDR enhancer to enhance CRISPR/Cas9- and TALEN-mediated knock-in efficiency
  84. RU-SKI 43, Hhat Inhibitor

    $139.00
    Catalog No. M60100
    The first potent and specific small molecule inhibitor of Hedgehog acyltransferase (Hhat).
  85. Ryuvidine, Lysine Methyltransferase SETD8 Inhibitor

    $129.00
    Catalog No. M60252
    A potent, selective and cell permeable lysine methyltransferase SETD8 inhibitor.
  86. SBI-0206965, Autophagy Kinase ULK1 Inhibitor

    $129.00
    Catalog No. M60268
    A potent, selective and cell permeable autophagy kinase ULK1 inhibitor.
  87. SCH51344, MTH1 Inhibitor

    $139.00
    Catalog No. M60212
    A novel potent, selective and cell permeable MTH1 inhibitor.
  88. SCR7, NHEJ inhibitor

    $129.00
    Catalog No. M60082
    A potent and selective inhibitor of non-homologous end joining (NHEJ).
  89. SD70, Histone Demethylase JMJD2 Inhibitor

    $139.00
    Catalog No. M60194
    A potent, selective and cell-permeable inhibitor of histone demethylase JMJD2 (KDM4C).
  90. Sephin1, PPP1R15A Protein Phosphatase Inhibitor

    $129.00
    Catalog No. M60280
    A potent, selective and bioavailable inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1.
  91. SGC-CBP30, p300/CBP Bromodomain Inhibitor

    $139.00
    Catalog No. M60138
    SGC-CBP30 is a highly potent and selective p300/CBP bromodomain inhibitor
  92. SGC0946, DOT1L inhibitor

    $139.00
    Catalog No. M60101
    A highly potent and selective inhibitor of DOT1L methyltransferase.
  93. SGC707, Allosteric PRMT3 Inhibitor

    $129.00
    Catalog No. M60243
    A potent, selective and cell permeable allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor.
  94. SGI-1027, DNMT Inhibitor

    $89.00
    Catalog No. M60155
    A potent and selective inhibitor of DNA methyltransferase (DNMT).
  95. SHP099, SHP2 Phosphatase Inhibitor

    $139.00
    Catalog No. M60319
    A highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor.
  96. SKP2-C25, Skp2 Inhibitor

    $139.00
    Catalog No. M60136
    A potent, selective and cell permeable Skp2 inhibitor, selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes.
  97. SMER3, SCF family E3 Ubiquitin Ligase Inhibitor

    $129.00
    Catalog No. M60250
    A potent and selective a yeast SCF family E3 ubiquitin ligase inhibitor, also a small-molecule enhancers of rapamycin.
  98. SR10067, REV-ERB Agonist

    $129.00
    Catalog No. M60240
    A potent and specific synthetic REV-ERB agonist.
  99. SR9009, REV-ERB Agonist

    $109.00
    Catalog No. M60236
    A potent and specific synthetic REV-ERB agonist.
  100. SR9011, REV-ERB Agonist

    $109.00
    Catalog No. M66049
    A potent synthetic REV-ERB agonist with in vivo activity; can regulate circadian behavior and metabolism.
  101. SR9243, LXR Inverse Agonist

    $129.00
    Catalog No. M60270
    A highly potent and selective small molecule LXR inverse agonist that induces LXR-corepressor interaction.
  102. SW033291, 15-PGDH Inhibitor

    $99.00
    Catalog No. M60298
    A highly potent and selective inhibitor of 15-PGDH to increase prostaglandin PGE2 levels in bone marrow and other tissues.
  103. Tasquinimod, Allosteric HDAC4 Inhibitor

    $129.00
    Catalog No. M60235
    A potent and selective allosteric HDAC4 inhibitor.
  104. TH588, MTH1 Inhibitor

    $139.00
    Catalog No. M60211
    A novel potent, selective and cell permeable MTH1 inhibitor.
  105. THZ1, Covalent CDK7 Inhibitor

    $159.00
    Catalog No. M60214
    A novel potent, selective and cell permeable irreversible CDK7 inhibitor.
  106. TMP269, Class IIa HDAC Inhibitor

    $129.00
    Catalog No. M60119
    A highly potent, selective and cell-permeable class IIa HDAC inhibitor.
  107. TMPA---AMPK Activator

    $119.00
    Catalog No. M60072
    TMPA is a novel small molecule that binds to orphan Nuclear Receptor Nur77 and activates AMPK.
  108. TRIM24-C34, BRPF1B/TRIM24 Dual Inhibitor

    $99.00
    Catalog No. M60265
    A potent, selective and cell permeable BRPF1B and TRIM24 dual inhibitor.
  109. TZ9, Rad6 Ubiquitin Inhibitor

    $109.00
    Catalog No. M60286
    A selective and cell permeable inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B.
  110. UNC0379, Lysine Methyltransferase SETD8 Inhibitor

    $129.00
    Catalog No. M60207
    A novel selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8
  111. UNC2170, Methyl-lysine Binding Protein 53BP1 Inhibitor

    $99.00
    Catalog No. M60260
    A selective and cell permeable methyl-lysine binding protein 53BP1 antagonist.
  112. UNC2327, Allosteric PRMT3 Inhibitor

    $129.00
    Catalog No. M60253
    A potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor.
  113. VLX600, Mitochondrial OXPHOS Inhibitor

    $69.00
    Catalog No. M60261
    A potent and selective mitochondrial OXPHOS inhibitor.
  114. VR23, Proteasome Inhibitor

    $99.00
    Catalog No. M60307
    A potent and selective proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 μM for trypsin-like proteasomes, chymotrypsin-like proteasomes,
  115. WAY-316606, Secreted Frizzled-related Protein-1 (sFRP-1) Inhibitor

    $139.00
    Catalog No. M60215
    A novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) to increase Wnt signaling.
  116. WDR5-0103, WDR5 Inhibitor

    $89.00
    Catalog No. M60233
    A potent and selective WD repeat-containing protein 5 (WDR5) antagonist.
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