DK419

DK419 is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. DK419 inhibited Wnt/β-catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally, and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.

Product information

CAS Number: 2102672-22-8

Molecular Weight: 407.70

Formula: C16H8ClF6N3O

Chemical Name: 6-chloro-2-(trifluoromethyl)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide

Smiles: O=C(NC1C=CC(=CC=1)C(F)(F)F)C1C=C(Cl)C=C2NC(=NC=12)C(F)(F)F

InChiKey: MWNNIGRGNSXNEA-UHFFFAOYSA-N

InChi: InChI=1S/C16H8ClF6N3O/c17-8-5-10(12-11(6-8)25-14(26-12)16(21,22)23)13(27)24-9-3-1-7(2-4-9)15(18,19)20/h1-6H,(H,24,27)(H,25,26)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Wang J, Mook RA Jr, Ren XR, Zhang Q, Jing G, Lu M, Spasojevic I, Lyerly HK,Hsu D, Chen W. Identification of DK419, a potent inhibitor of Wnt/β-cateninsignaling and colorectal cancer growth. Bioorg Med Chem. 2018 Sep 17. pii:S0968-0896(18)31138-6. doi: 10.1016/j.bmc.2018.09.016. [Epub ahead of print]PubMed PMID: 30274939.

Products are for research use only. Not for human use.