EBI2 is expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. It is also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain. EBI2 is an orphan receptor that plays a central role during humoral immunity and promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses.
NIBR189
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