Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution.
PROTAC CDK9 Degrader-1
From $385
Purvalanol A
From $84
Purvalanol B
From $90
R547
From $160
RGB-286638
From $95
RGB-286638 free base
From $95
Ro-3306
From $85
Roscovitine (Seliciclib)
From $100
SB-218078
From $412
SB1317
From $95
SNS-032
From $85
SU9516
From $95
TG003
From $100
THAL SNS 032
From $245
THZ1 --- Covalent CDK7 Inhibitor
From $159
TL 12-186
From $390
Trilaciclib
From $100
Wogonin
From $122
XL413
From $90
YKL-5-124
From $385