2-Fluoro-fucose

2-Fluoro-fucose is a fluorinated analog of fucose that can be taken up and metabolized to the desired donor substrate-based inhibitor of fucosyltransferases inside the cell. It also acts to prevent the de novo synthesis of the natural substrates, resulting in a global, family-wide shutdown of fucosyltransferases and remodeling of cell surface glycans. 2-Fluoro-fucose also inhibits fucosylation of plant cell wall polysaccharides. In addition, 2-Fluoro-fucose demonstrated antitumor activity in mouse cancer models. Fucosylation inhibitor. Reduces fucosylation of IgG in antibodies, which increases therapeutic efficacies of antibodies that cause antibody-dependent cellular cytotoxicity.

Product information

CAS Number: 70763-62-1

Molecular Weight: 166.15

Formula: C6H11FO4

Synonym:

SGN-2FF

2-Deoxy-2-fluoro-L-fucose

2F-Fuc

Chemical Name: (3S, 4R, 5S, 6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2, 4, 5-triol

Smiles: C[C@@H]1OC(O)[C@@H](F)[C@H](O)[C@@H]1O

InChiKey: IRKXGKIPOMIQOD-ZZWDRFIYSA-N

InChi: InChI=1S/C6H11FO4/c1-2-4(8)5(9)3(7)6(10)11-2/h2-6,8-10H,1H3/t2-,3-,4+,5-,6?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zhou Y, Fukuda T, Hang Q, Hou S, Isaji T, Kameyama A, Gu J., Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation. Sci Rep. 2017 Sep 14;7(1):11563.
2. Duan C, Fukuda T, Isaji T, Qi F, Yang J, Wang Y, Takahashi S, Gu J. Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system. FASEB J. 2020 Feb;34(2):3239-3252.

Products are for research use only. Not for human use.