Pemirolast potassium

Pemirolast potassium, also known as BMY 26517, is a potent histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. It has also been studied for the treatment of asthma. Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. Pemirolast reduces cisplatin-induced kaolin intake in rats.

Product information

CAS Number: 100299-08-9

Molecular Weight: 266.30

Formula: C10H7KN6O

Synonym:

BMY26517

TWT-8152

BMY 26517

BMY-26517

TWT8152

TWT 8152

Chemical Name: 9-methyl-3-(1H-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium

Smiles: [K+].CC1=CC=CN2C(=O)C(=CN=C21)C1=N[N-]N=N1

InChiKey: NMMVKSMGBDRONO-UHFFFAOYSA-N

InChi: InChI=1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : ≥ 200 mg/mL (751.03 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Itoh, Y., et al., Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. Neuropharmacology, 2004. 46(6): p. 888-94.
2. Abelson, M.B., et al., Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies. J Ocul Pharmacol Ther, 2002. 18(5): p. 475-88.
3. Tatsushima, Y., et al., Pemirolast reduces cisplatin-induced kaolin intake in rats. Eur J Pharmacol, 2011. 661(1-3): p. 57-62.

Products are for research use only. Not for human use.