UNC6934

UNC6934 is a novel potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 ± 18 nM, being selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1, the closest on the phylogenetic tree, disrupting the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells.

Product information

CAS Number: 2561494-77-5

Molecular Weight: 443.45

Formula: C24H21N5O4

Chemical Name: N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3, 4-dihydro-2H-benzo[b][1, 4]oxazine-7-carboxamide

Smiles: O=C1COC2=CC(=CC=C2N1)C(=O)N(CC1C=CC(=CC=1)C(=O)NC1=CC=NC=N1)C1CC1

InChiKey: KOZGEDUWAQFVAV-UHFFFAOYSA-N

InChi: InChI=1S/C24H21N5O4/c30-22-13-33-20-11-17(5-8-19(20)27-22)24(32)29(18-6-7-18)12-15-1-3-16(4-2-15)23(31)28-21-9-10-25-14-26-21/h1-5,8-11,14,18H,6-7,12-13H2,(H,27,30)(H,25,26,28,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.