VER-49009

VER-49009 is a potent HSP90 inhibitor. VER-49009 inhibits Hsp90 with an IC50 value of 47 nM. VER-49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.

Product information

CAS Number: 558640-51-0

Molecular Weight: 387.82

Formula: C19H18ClN3O4

Synonym:

VER49009

VER 49009

CCT129397

CCT 129397

CCT-129397

Chemical Name: 3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide

Smiles: CCNC(=O)C1NN=C(C2=CC(Cl)=C(O)C=C2O)C=1C1C=CC(=CC=1)OC

InChiKey: HUNAOTXNHVALTN-UHFFFAOYSA-N

InChi: InChI=1S/C19H18ClN3O4/c1-3-21-19(26)18-16(10-4-6-11(27-2)7-5-10)17(22-23-18)12-8-13(20)15(25)9-14(12)24/h4-9,24-25H,3H2,1-2H3,(H,21,26)(H,22,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.