OTSSP167 Hydrochloride

OTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells.

Product information

CAS Number: 1431698-10-0

Molecular Weight: 523.88

Formula: C25H29Cl3N4O2

Chemical Name: 1-(6-(3, 5-dichloro-4-hydroxyphenyl)-4-((1r, 4r)-4-((dimethylamino)methyl)cyclohexylamino)-1, 5-naphthyridin-3-yl)ethanone hydrochloride

Smiles: Cl.CC(=O)C1=CN=C2C=CC(=NC2=C1N[C@@H]1CC[C@@H](CN(C)C)CC1)C1=CC(Cl)=C(O)C(Cl)=C1

InChiKey: XDGWHISAOWEFML-BFLZMHAMSA-N

InChi: InChI=1S/C25H28Cl2N4O2.ClH/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3;/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29);1H/t15-,17-;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.