tCFA15

tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.

Product information

CAS Number: 220757-88-0

Molecular Weight: 364.60

Formula: C24H44O2

Chemical Name: 3-(15-hydroxypentadecyl)-2, 4, 4-trimethylcyclohex-2-en-1-one

Smiles: CC1C(=O)CCC(C)(C)C=1CCCCCCCCCCCCCCCO

InChiKey: FGMAOXGOTRUOKJ-UHFFFAOYSA-N

InChi: InChI=1S/C24H44O2/c1-21-22(24(2,3)19-18-23(21)26)17-15-13-11-9-7-5-4-6-8-10-12-14-16-20-25/h25H,4-20H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 130 mg/mL (356.56 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

tCFA15 (10 nM-1 μM) dose-dependently affects the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and such effect is via Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis.

References:

1. Bouissac J, et al. tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol, affects neural stem fate and differentiation by modulating Notch1 activity. Eur J Pharmacol. 2013 Oct 15;718(1-3):383-92.
2. Girlanda-Junges C, et al. 3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2537-9.

Products are for research use only. Not for human use.