Description
Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major.
Product information
CAS Number: 239101-33-8
Molecular Weight: 253.27
Formula: C11H11NO4S
Chemical Name: (4S)-2-(2,4-dihydroxyphenyl)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid
Smiles: C[C@@]1(CSC(=N1)C1=CC=C(O)C=C1O)C(O)=O
InChiKey: OEUUFNIKLCFNLN-LLVKDONJSA-N
InChi: InChI=1S/C11H11NO4S/c1-11(10(15)16)5-17-9(12-11)7-3-2-6(13)4-8(7)14/h2-4,13-14H,5H2,1H3,(H,15,16)/t11-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
The iron-clearing efficiency (ICE) of Deferitrin (GT-56-252) in a non-iron-overloaded rodent model after oral (po) administration at 300 µmol/kg is shown to be 1.1%.
Products are for research use only. Not for human use.
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