DMT1 blocker 2

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.

Product information

CAS Number: 1062648-63-8

Molecular Weight: 263.29

Formula: C16H13N3O

Chemical Name: 2-(pyridin-2-yl)-1H,2H,3H,4H,5H-benzo[e]indazol-1-one

Smiles: O=C1C2C3=CC=CC=C3CCC=2NN1C1=CC=CC=N1

InChiKey: BKZBNMNLRQXSHY-UHFFFAOYSA-N

InChi: InChI=1S/C16H13N3O/c20-16-15-12-6-2-1-5-11(12)8-9-13(15)18-19(16)14-7-3-4-10-17-14/h1-7,10,18H,8-9H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (189.90 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DMT1 blocker 2 (Compound 12f) (10 μM; 24 h) has no cytotoxic to HepG2 cells. DMT1 blocker 2 (10 μM) inhibits 44% of CYP3A4 activity.

In Vivo:

DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption.

Products are for research use only. Not for human use.