MDK-8650

MDK-8650, also known as PKC-theta inhibitor, is a selective PKC-θinhibitor, with an IC50 of 12 nM.

Product information

CAS Number: 736048-65-0

Molecular Weight: 454.45

Formula: C20H25F3N6O3

Synonym:

MDK8650

PKC-theta inhibito

Chemical Name:  N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitro-N2-(2-(trifluoromethoxy)benzyl)pyrimidine-2,4-diamine

Smiles: NCC1CCC(CNC2=NC(NCC3=CC=CC=C3OC(F)(F)F)=NC=C2[N+]([O-])=O)CC1

InChiKey: HKOWATVSFKRXRW-UHFFFAOYSA-N

InChi: InChI=1S/C20H25F3N6O3/c21-20(22,23)32-17-4-2-1-3-15(17)11-26-19-27-12-16(29(30)31)18(28-19)25-10-14-7-5-13(9-24)6-8-14/h1-4,12-14H,5-11,24H2,(H2,25,26,27,28)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambien...

Storage Condition: Dry, dark and -20 ^oC...

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG, Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H, Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR Jr, Brown ML. Discovery of potent and selective PKC-theta inhibitors. Bioorg Med hem Lett. 2007 Jan 1;17(1):225-30. Epub 2006 Oct 19. PubMed PMID: 17055721.

Products are for research use only. Not for human use.