PROTAC BET degrader-2

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

Product information

CAS Number: 2093388-33-9

Molecular Weight: 770.84

Formula: C41H42N10O6

Chemical Name: 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3, 5-dimethyl-1, 2-oxazol-4-yl)-N-{3-[2-(2, 6-dioxopiperidin-3-yl)-1-oxo-2, 3-dihydro-1H-isoindol-4-yl]propyl}-6-methoxy-9H-pyrimido[4, 5-b]indole-2-carboxamide

Smiles: COC1C=C2C3C(NC2=CC=1C1=C(C)ON=C1C)=NC(=NC=3NC1=CC(=NN1CC)C1CC1)C(=O)NCCCC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O

InChiKey: LKCUEUQTTCOYPW-UHFFFAOYSA-N

InChi: InChI=1S/C41H42N10O6/c1-5-51-32(18-28(48-51)23-11-12-23)44-37-35-25-17-31(56-4)26(34-20(2)49-57-21(34)3)16-29(25)43-36(35)46-38(47-37)40(54)42-15-7-9-22-8-6-10-24-27(22)19-50(41(24)55)30-13-14-33(52)45-39(30)53/h6,8,10,16-18,23,30H,5,7,9,11-15,19H2,1-4H3,(H,42,54)(H,45,52,53)(H2,43,44,46,47)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (64.86 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

References:

1. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

Products are for research use only. Not for human use.