Description
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor for SIK1, SIK2 and SIK3. Inhibition of SIK kinase activity induces an anti-inflammatory phenotype in macrophages.
Product information
CAS Number: 1456858-58-4
Molecular Weight: 567.68
Formula: C32H37N7O3
Chemical Name: 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)urea
Smiles: CN1CCN(CC1)C1C=CC(=CC=1)NC1=CC(=NC=N1)N(C(=O)NC1C(C)=CC=CC=1C)C1=CC=C(C=C1OC)OC
InChiKey: UYUHRKLITDJEHB-UHFFFAOYSA-N
InChi: InChI=1S/C32H37N7O3/c1-22-7-6-8-23(2)31(22)36-32(40)39(27-14-13-26(41-4)19-28(27)42-5)30-20-29(33-21-34-30)35-24-9-11-25(12-10-24)38-17-15-37(3)16-18-38/h6-14,19-21H,15-18H2,1-5H3,(H,36,40)(H,33,34,35)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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