Description
m-PEG5-nitrile is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 81836-41-1
Molecular Weight: 261.31
Formula: C12H23NO5
Chemical Name: 2,5,8,11,14-pentaoxaheptadecane-17-nitrile
Smiles: COCCOCCOCCOCCOCCC#N
InChiKey: SZUWOHFZIMGHKQ-UHFFFAOYSA-N
InChi: InChI=1S/C12H23NO5/c1-14-5-6-16-9-10-18-12-11-17-8-7-15-4-2-3-13/h2,4-12H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Saifer MG, et al. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46.
Products are for research use only. Not for human use.
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