Description
Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.
Product information
CAS Number: 115088-06-7
Molecular Weight: 326.39
Formula: C13H14N2O4S2
Synonym:
SPDB
Chemical Name: (2, 5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate
Smiles: O=C(CCCSSC1=CC=CC=N1)ON1C(=O)CCC1=O
InChiKey: JSHOVKSMJRQOGY-UHFFFAOYSA-N
InChi: InChI=1S/C13H14N2O4S2/c16-11-6-7-12(17)15(11)19-13(18)5-3-9-20-21-10-4-1-2-8-14-10/h1-2,4,8H,3,5-7,9H2
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Ethanol : 100 mg/mL (306.38 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26(11):2261-78.
Products are for research use only. Not for human use.
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