Language:English
Language:

Xcessbio

Place your promotion here

You have no items in your shopping cart.

BAM7, BAX Activator

BAM7, BAX Activator

$109.00
The first potent and selective small molecule activator of BAX, which is a pro-apoptotic BCL-2 family member.
Catalog No. Unit Price Qty
M60069-2s 2 mg solid $109.00
M60069-2 10 mM in DMSO (0.494 mL) $109.00

Details

Product Information
Molecular Weight: 405.47
Formula: C21H19N5O2S
Purity: ≥98%
CAS#: 331244-89-4
Solubility: DMSO up to 100 mM
Chemical Name: (E)-4-(2-(2-ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

BAM7 is the first potent and selective small molecule activator of BAX, which is a pro-apoptotic BCL-2 family member. It binds the BAX trigger site with an EC50 ~ 3.3 μM as measured in a competitive FP assay using FITC-BIM SAHB and BAX. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation, and does not interact with the BH3-binding pocket of antiapoptotic proteins or proapoptotic BAK. It induces cell death in a BAX-dependent fashion. It can also induce the biochemical and morphologic features of BAX-mediated apoptosis in Bak-/- MEFs. BAM7 is selective for the BH3-binding groove at the N-terminal face of BAX and thus may serve as a powerful chemical tool for dissecting the physiologic consequences of direct BAX activation in a variety of homeostatic and pathologic conditions. 

 

How to Use:

In vitro:  BAM7 was used at 10-30 µM final concentration in vitro and in cellular assays.

In vivo: n/a 

 

Reference:

  1.  1. Gavathiotis E, et al. Direct and selective small-molecule activation of proapoptotic BAX. (2012) Nat Chem Biol. 8(7):639-45.



BAM7_spec.pdf

BAM7_MSDS.pdf


 Products are for research use only. Not for human use. 

Description

Details

Product Information
Molecular Weight: 405.47
Formula: C21H19N5O2S
Purity: ≥98%
CAS#: 331244-89-4
Solubility: DMSO up to 100 mM
Chemical Name: (E)-4-(2-(2-ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

BAM7 is the first potent and selective small molecule activator of BAX, which is a pro-apoptotic BCL-2 family member. It binds the BAX trigger site with an EC50 ~ 3.3 μM as measured in a competitive FP assay using FITC-BIM SAHB and BAX. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation, and does not interact with the BH3-binding pocket of antiapoptotic proteins or proapoptotic BAK. It induces cell death in a BAX-dependent fashion. It can also induce the biochemical and morphologic features of BAX-mediated apoptosis in Bak-/- MEFs. BAM7 is selective for the BH3-binding groove at the N-terminal face of BAX and thus may serve as a powerful chemical tool for dissecting the physiologic consequences of direct BAX activation in a variety of homeostatic and pathologic conditions. 

 

How to Use:

In vitro:  BAM7 was used at 10-30 µM final concentration in vitro and in cellular assays.

In vivo: n/a 

 

Reference:

  1.  1. Gavathiotis E, et al. Direct and selective small-molecule activation of proapoptotic BAX. (2012) Nat Chem Biol. 8(7):639-45.



BAM7_spec.pdf

BAM7_MSDS.pdf


 Products are for research use only. Not for human use. 

Reviews

Write Your Review

How do you rate this product? *

Price:
Value:
Quality: