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StemRegenin1 (SR1)---HSC Expansion Molecule

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StemRegenin1 (SR1)---HSC Expansion Molecule

$99.00
A potent and selective aryl hydrocarbon receptor antagonist; can promote robust expansion of human CD34+ hematopoietic stem and progenitor cells.
Catalog No. Unit Price Qty
M60001-2s 2 mg solid $99.00
M60001-2 10 mM in DMSO (0.466 mL) $99.00

Details

Product Information
Molecular Weight: 429.54
Formula: C24H23N5OS
Purity: ≥98%
CAS#: 1227633-49-9
Solubility: DMSO up to 100 mM
Chemical Name: 4-(2-((2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

StemRegenin1 (SR1) is a selective, cell-permeable antagonist of aryl hydrocarbon receptor.. It can promote robust expansion and self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs, EC50 ~120 nM). SR1 expanded CD34+ cells from bone marrow of humans, monkeys and dogs, but not mice. Culture of HSCs with 1 µM SR1 for 21 days led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Currently Novartis is conducting clinical trials, “LFU835-expanded Umbilical Cord Blood Hematopoietic Stem Cells in Patients With Hematological Malignancies”, related to this research.


How to Use:

  • In vitro: SR1 was used at 1 µM final concentration (DMSO 0.01%) in the ex vivo cell culture for 7-21 days. SR1 may be refreshed every 2-3 days during the culture.
  • In vivo: n/a


Reference:

  • 1. Anthony E. Boitano et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. (2010) Science 329(5997):1345-8
  • 2. Csaszar E, et al. Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.(2012) Cell Stem Cell.10(2):218-29.


Products are for research use only. Not for human use.


Description

Details

Product Information
Molecular Weight: 429.54
Formula: C24H23N5OS
Purity: ≥98%
CAS#: 1227633-49-9
Solubility: DMSO up to 100 mM
Chemical Name: 4-(2-((2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

StemRegenin1 (SR1) is a selective, cell-permeable antagonist of aryl hydrocarbon receptor.. It can promote robust expansion and self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs, EC50 ~120 nM). SR1 expanded CD34+ cells from bone marrow of humans, monkeys and dogs, but not mice. Culture of HSCs with 1 µM SR1 for 21 days led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Currently Novartis is conducting clinical trials, “LFU835-expanded Umbilical Cord Blood Hematopoietic Stem Cells in Patients With Hematological Malignancies”, related to this research.


How to Use:

  • In vitro: SR1 was used at 1 µM final concentration (DMSO 0.01%) in the ex vivo cell culture for 7-21 days. SR1 may be refreshed every 2-3 days during the culture.
  • In vivo: n/a


Reference:

  • 1. Anthony E. Boitano et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. (2010) Science 329(5997):1345-8
  • 2. Csaszar E, et al. Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.(2012) Cell Stem Cell.10(2):218-29.


Products are for research use only. Not for human use.


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