Description
A-443654 is a potent and selective AKT inhibitor. A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. A-443654 interferes with mitotic progression by regulating aurora a kinase expression.
Product information
CAS Number: 552325-16-3
Molecular Weight: 397.47
Formula: C24H23N5O
Chemical Name: (2S)-1-(1H-indol-3-yl)-3-{[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine
Smiles: CC1NN=C2C=CC(=CC2=1)C1=CN=CC(=C1)OC[C@@H](N)CC1=CNC2=CC=CC=C12
InChiKey: YWTBGJGMTBHQTM-IBGZPJMESA-N
InChi: InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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