CHIR99021 is the most widely used, potent and selective inhibitor of glycogen synthase kinase 3β (GSK3β) with an IC50 ~7 nM. It can effectively activate Wnt signaling pathway in various cellular systems. CHIR99021 has been shown to enhance the reprogramming of murine and human somatic cells into iPSCs, potently promote expansion of embryonic stem cells and tissue-specific adult stem cells, and induce differentiation of human ESCs/iPSCs toward neural or mesendoderm lineages under appropriate conditions.

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