Monoamine transporters are transmembrane proteins located in plasma membranes of monoaminergic neurons, including the dopamine transporter (DAT), serotonin transporter (SERT, also expressed in platelets), and norepinephrine transporter (NET). These proteins use ion (Na+, Cl–) gradients as energy sources to move monoamines into or out of neurons. The major function of these transporters is to terminate monoamine transmission by inward transport of substrates away from the synaptic cleft.
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