Endothelin receptors consist of a single polypeptide chain that spans the membrane seven times, with the amino terminal being extracellular and the carboxy terminal intracellular. Endothelin receptors can be divided into ETA and ETB receptors. ET-1 has similar affinity for ETA and ETB receptors. The ETA and ETB receptors are different pharmacologically in that a different big ET-1 metabolite, ET-3, has little affinity for the ETA receptor and a significantly greater affinity for the ETB receptor.
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